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Journal articles
Synthesis of new sulfonate and phosphonate derivatives for cation-independent mannose 6-phosphate receptor targeting.
Abstract : The cation-independent mannose 6-phosphate receptor (CI-M6PR) is essential for the endocytosis of proteins bearing the mannose 6-phosphate (M6P) recognition marker. This study described the synthesis of M6P and M6S analogs presenting greater affinity for CI-M6PR than their natural compounds. Moreover, the finding of their lack of cytotoxicity for human cells and of their increased stability in human serum supports the high potential of these isosteric derivatives in therapies requiring CI-M6PR targeting.
https://www.hal.inserm.fr/inserm-00339550
Contributor : Yves Le Ster Connect in order to contact the contributor
Submitted on : Thursday, November 20, 2008 - 12:32:27 PM
Last modification on : Tuesday, July 5, 2022 - 9:03:08 AM
Long-term archiving on: : Tuesday, September 18, 2012 - 12:30:21 PM
Contributor : Yves Le Ster Connect in order to contact the contributor
Submitted on : Thursday, November 20, 2008 - 12:32:27 PM
Last modification on : Tuesday, July 5, 2022 - 9:03:08 AM
Long-term archiving on: : Tuesday, September 18, 2012 - 12:30:21 PM
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