Synthesis of new sulfonate and phosphonate derivatives for cation-independent mannose 6-phosphate receptor targeting. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Bioorganic and Medicinal Chemistry Letters Year : 2008

Synthesis of new sulfonate and phosphonate derivatives for cation-independent mannose 6-phosphate receptor targeting.

Abstract

The cation-independent mannose 6-phosphate receptor (CI-M6PR) is essential for the endocytosis of proteins bearing the mannose 6-phosphate (M6P) recognition marker. This study described the synthesis of M6P and M6S analogs presenting greater affinity for CI-M6PR than their natural compounds. Moreover, the finding of their lack of cytotoxicity for human cells and of their increased stability in human serum supports the high potential of these isosteric derivatives in therapies requiring CI-M6PR targeting.
Fichier principal
Vignette du fichier
inserm-00339550_edited.pdf (388.98 Ko) Télécharger le fichier
Auteur_Version_Jeanjean_Gary-bobo_M_Morere_Template_wordXP.pdf (332.47 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)

Dates and versions

inserm-00339550 , version 1 (20-11-2008)

Identifiers

Cite

Audrey Jeanjean, Magali Gary-Bobo, Philippe Nirdé, Simon Leiris, Marcel Garcia, et al.. Synthesis of new sulfonate and phosphonate derivatives for cation-independent mannose 6-phosphate receptor targeting.. Bioorganic and Medicinal Chemistry Letters, 2008, 18 (23), pp.6240-3. ⟨10.1016/j.bmcl.2008.09.101⟩. ⟨inserm-00339550⟩
364 View
2659 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More