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Cancer incidence and mortality in France over the period 1980-2005.

Aurélien Belot 1, 2, 3 Pascale Grosclaude 4 Nadine Bossard 2 Eric Jougla 5 Ellen Benhamou 6 Patricia Delafosse 7 Anne Valérie Guizard 8 Florence Molinié 9 Arlette Danzon 10 Simona Bara 11 Anne Marie Bouvier 12 Brigitte Trétarre 13 Florence Binder-Foucard 14 Marc Colonna 7, 15 Laetitia Daubisse 16 Guy Hédelin 17 Guy Launoy 18 Nolwenn Le Stang 19 Marc Maynadié 20 Alain Monnereau 21 Xavier Troussard 22 Jean Faivre 12 Anne Collignon 22 Inès Janoray 20 Patrick Arveux 23 Antoine Buemi 24 Nicole Raverdy 25 Claire Schvartz 26 Martine Bovet 5 Laurence Chérié-Challine 3 Jaume Esteve 1, 2 L. Remontet 1, 2 M. Velten 17
Abstract : BACKGROUND: The objective of this study was to provide updated estimates of national trends in cancer incidence and mortality for France for 1980-2005. METHODS: Twenty-five cancer sites were analysed. Incidence data over the 1975-2003 period were collected from 17 registries working at the department level, covering 16% of the French population. Mortality data for 1975-2004 were provided by the Inserm. National incidence estimates were based on the use of mortality as a correlate of incidence, mortality being available at both department and national levels. Observed incidence and mortality data were modelled using an age-cohort approach, including an interaction term. Short-term predictions from that model gave estimates of new cancer cases and cancer deaths in 2005 for France. RESULTS: The number of new cancer cases in 2005 was approximately 320,000. This corresponds to an 89% increase since 1980. Demographic changes were responsible for almost half of that increase. The remainder was largely explained by increases in prostate cancer incidence in men and breast cancer incidence in women. The relative increase in the world age-standardised incidence rate was 39%. The number of deaths from cancer increased from 130,000 to 146,000. This 13% increase was much lower than anticipated on the basis of demographic changes (37%). The relative decrease in the age-standardised mortality rate was 22%. This decrease was steeper over the 2000-2005 period in both men and women. Alcohol-related cancer incidence and mortality continued to decrease in men. The increasing trend of lung cancer incidence and mortality among women continued; this cancer was the second cause of cancer death among women. Breast cancer incidence increased regularly, whereas mortality has decreased slowly since the end of the 1990s. CONCLUSION: This study confirmed the divergence of cancer incidence and mortality trends in France over the 1980-2005 period. This divergence can be explained by the combined effects of a decrease in the incidence of the most aggressive cancers and an increase in the incidence of less aggressive cancers, partly due to changes in medical practices leading to earlier diagnoses.
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https://www.hal.inserm.fr/inserm-00338335
Contributor : Aurélien Vesin <>
Submitted on : Wednesday, November 12, 2008 - 5:48:42 PM
Last modification on : Wednesday, June 10, 2020 - 2:06:49 PM

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Aurélien Belot, Pascale Grosclaude, Nadine Bossard, Eric Jougla, Ellen Benhamou, et al.. Cancer incidence and mortality in France over the period 1980-2005.. Epidemiology and Public Health / Revue d'Epidémiologie et de Santé Publique, Elsevier Masson, 2008, 56 (3), pp.159-75. ⟨10.1016/j.respe.2008.03.117⟩. ⟨inserm-00338335⟩

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