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Long-term follow-up of 111 patients with persistent polyclonal B-cell lymphocytosis with binucleated lymphocytes.

Abstract : Initially described in 1982, the persistent polyclonal B-cell lymphocytosis (PPBL) is characterized by a chronic, stable, persistent and polyclonal lymphocytosis, the presence of binucleated lymphocytes in the peripheral blood and a polyclonal increase in serum immunoglobulin-M (IgM). In this apparently benign entity, we showed that PPBL was associated with recurrent chromosomal abnormalities and a typical cytogenetic profile including isochromosome 3q, +i(3q), premature chromosome condensation (PCC), both abnormalities in the same patient or chromosomal instability. Despite clinical and polyclonal lymphocytosis stability, the long-term follow-up is not yet well established.We analyse and report here the long-term follow-up of 111 patients with typical PPBL.
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https://www.hal.inserm.fr/inserm-00338136
Contributor : Edouard Cornet <>
Submitted on : Thursday, January 22, 2009 - 10:46:47 AM
Last modification on : Wednesday, September 30, 2020 - 11:38:03 AM
Long-term archiving on: : Tuesday, September 18, 2012 - 12:31:38 PM

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Edouard Cornet, Jean François Lesesve, Hossein Mossafa, Gérard Sébahoun, Vincent Levy, et al.. Long-term follow-up of 111 patients with persistent polyclonal B-cell lymphocytosis with binucleated lymphocytes.. Leukemia, Nature Publishing Group: Open Access Hybrid Model Option B, 2009, 23 (2), pp.419-22. ⟨10.1038/leu.2008.208⟩. ⟨inserm-00338136⟩

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