Long-term follow-up of 111 patients with persistent polyclonal B-cell lymphocytosis with binucleated lymphocytes. - Archive ouverte HAL Access content directly
Journal Articles Leukemia Year : 2009

Long-term follow-up of 111 patients with persistent polyclonal B-cell lymphocytosis with binucleated lymphocytes.

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Abstract

Initially described in 1982, the persistent polyclonal B-cell lymphocytosis (PPBL) is characterized by a chronic, stable, persistent and polyclonal lymphocytosis, the presence of binucleated lymphocytes in the peripheral blood and a polyclonal increase in serum immunoglobulin-M (IgM). In this apparently benign entity, we showed that PPBL was associated with recurrent chromosomal abnormalities and a typical cytogenetic profile including isochromosome 3q, +i(3q), premature chromosome condensation (PCC), both abnormalities in the same patient or chromosomal instability. Despite clinical and polyclonal lymphocytosis stability, the long-term follow-up is not yet well established.We analyse and report here the long-term follow-up of 111 patients with typical PPBL.
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Dates and versions

inserm-00338136 , version 1 (22-01-2009)

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Edouard Cornet, Jean François Lesesve, Hossein Mossafa, Gérard Sébahoun, Vincent Levy, et al.. Long-term follow-up of 111 patients with persistent polyclonal B-cell lymphocytosis with binucleated lymphocytes.. Leukemia, 2009, 23 (2), pp.419-22. ⟨10.1038/leu.2008.208⟩. ⟨inserm-00338136⟩
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