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[RNase L, a crucial mediator of innate immunity and other cell functions.]

Catherine Bisbal 1, * Tamim Salehzada 1
* Corresponding author
Abstract : The 2-5A/RNase L pathway is one of the first cellular defences against viruses. RNase L is an unusual endoribonuclease which activity is strictly regulated by its binding to a small oligonucleotide, 2-5A. 2-5A itself is very unusual, consisting of a series of 5'- triphosphorylated oligoadenylates with 2'-5' bonds. But RNase L activity is not limited to viral RNA cleavage. RNase L plays a central role in innate immunity, apoptosis, cell growth and differentiation by regulating cellular RNA stability and expression. Default in its activity leads to increased susceptibility to virus infections and to tumor development. RNase L gene has been identified as HPC1 (Hereditary Prostate Cancer 1) gene. Study of RNase L variant R462Q in etiology of prostate cancer has led to the identification of the novel human retrovirus closely related to xenotropic murine leukemia viruses (MuLVs) and named XMRV;
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https://www.hal.inserm.fr/inserm-00338036
Contributor : Catherine Bisbal <>
Submitted on : Monday, November 10, 2008 - 4:01:48 PM
Last modification on : Monday, December 2, 2019 - 9:48:01 AM
Long-term archiving on: : Monday, June 7, 2010 - 9:14:44 PM

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  • HAL Id : inserm-00338036, version 1
  • PUBMED : 18950583

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Catherine Bisbal, Tamim Salehzada. [RNase L, a crucial mediator of innate immunity and other cell functions.]. médecine/sciences, EDP Sciences, 2008, 24 (10), pp.859-64. ⟨inserm-00338036⟩

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