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Changes in causes of death among adults infected by HIV between 2000 and 2005: The "Mortalité 2000 and 2005" surveys (ANRS EN19 and Mortavic).

Abstract : BACKGROUND: The multicenter national Mortalité 2005 survey aimed at describing the distribution of causes of death among HIV-infected adults in France in 2005 and its changes as compared with 2000. METHODS: Physicians involved in the management of HIV infection notified deaths and documented the causes using a standardized questionnaire similar to the previous survey performed in 2000. RESULTS: Overall, 1042 deaths were notified in 2005 (vs 964 in 2000): with median age, 46 years (vs 41 years); men, 76%; and median last CD4 cell count, 161/mm (vs 94). The proportion of underlying causes of death due to AIDS decreased (36% in 2005 vs 47% in 2000), and the proportion of cancer not related to AIDS or hepatitis (17% vs 11%), liver related disease (15% vs 13%: hepatitis C, 11%, and hepatitis B, 2%), cardiovascular disease (8% vs 7%), or suicide (5% vs 4%) increased. Among the 375 AIDS-related deaths, the most frequent event was non-Hodgkin lymphoma (28%). Among cancers not related to AIDS or hepatitis, the most frequent localizations were lung (31%) and digestive tract (14%). Among the 154 liver-related deaths, 24% were due to hepatocarcinoma. CONCLUSIONS: The heterogeneity of causes of death among HIV-infected adults was confirmed and intensified in 2005, with 3 causes following AIDS: cancers and liver-related and cardiovascular diseases.
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https://www.hal.inserm.fr/inserm-00337877
Contributor : Evelyne Mouillet <>
Submitted on : Thursday, May 22, 2014 - 10:51:57 AM
Last modification on : Wednesday, August 19, 2020 - 11:18:04 AM
Long-term archiving on: : Friday, August 22, 2014 - 10:36:00 AM

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Charlotte Lewden, Thierry May, Eric Rosenthal, Christine Burty, Fabrice Bonnet, et al.. Changes in causes of death among adults infected by HIV between 2000 and 2005: The "Mortalité 2000 and 2005" surveys (ANRS EN19 and Mortavic).. Journal of Acquired Immune Deficiency Syndromes, Lippincott, Williams & Wilkins, 2008, 48 (5), pp.590-8. ⟨10.1097/QAI.0b013e31817efb54⟩. ⟨inserm-00337877⟩

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