Pregnancy may be followed by an inflexion of the immune reconstitution in HIV-infected women who receive antiretroviral drugs before conception. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue HIV Medicine Année : 2008

Pregnancy may be followed by an inflexion of the immune reconstitution in HIV-infected women who receive antiretroviral drugs before conception.

Résumé

BACKGROUND: Whether pregnancy has an impact on the evolution of CD4 cell counts in women treated with highly potent antiretrovirals before conception remains largely unknown. METHODS: Among patients enrolled in the ANRS CO8 (APROCO/COPILOTE) cohort, we selected all women aged between 18 and 50 years at initiation of combination antiretroviral therapy (cART). Slopes of CD4 cell counts during follow-up were estimated using mixed longitudinal models with time-dependent indicators for pregnancy and delivery. RESULTS: Of the 260 selected HIV-infected women, a pregnancy occurred in 39 women in a median follow-up time of 66 months. Women who became pregnant had higher CD4 cell count at baseline but this difference progressively lessened during follow-up because they had a slower increase than women who did not become pregnant. The estimated slope of CD4 cell count decreased significantly from +2.3 cells/muL/month before pregnancy and in women who did not become pregnant to -0.04 cells/microL/month after delivery (P=0.0003). CONCLUSION: A significant increase in CD4 cell count may be preferable before pregnancy in women treated with cART, in order to overcome the evolution observed after pregnancy.
Fichier principal
Vignette du fichier
HIV_Med_V3.pdf (211.95 Ko) Télécharger le fichier
inserm-00336919_edited.pdf (98.21 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

inserm-00336919 , version 1 (06-11-2008)

Identifiants

Citer

Vincent Le-Moing, Audrey Taieb, Pascale Longuet, Charlotte Lewden, Véronique Delcey, et al.. Pregnancy may be followed by an inflexion of the immune reconstitution in HIV-infected women who receive antiretroviral drugs before conception.. HIV Medicine, 2008, 9 (10), pp.897-900. ⟨10.1111/j.1468-1293.2008.00641.x⟩. ⟨inserm-00336919⟩
377 Consultations
678 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More