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Journal Articles European Journal of Immunology Year : 2005

Splenic marginal zone B cells in humans: where do they mutate their Ig receptor?

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Abstract

Human IgM+ IgD+ CD27+ B cells have mutated Ig genes and harbor a splenic marginal zone (MZ) phenotype. In this issue, the group of R. K?rs has studied the expression of the enzyme activation-induced cytidine deaminase (AID) in human spleen samples by immunocytochemistry and failed to detect a significant AID-expressing subset in the MZ region. The consequences on the possible origin of these cells are discussed.
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Dates and versions

inserm-00336844 , version 1 (05-11-2008)

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Sandra Weller, Claude-Agnès Reynaud, Jean-Claude Weill. Splenic marginal zone B cells in humans: where do they mutate their Ig receptor?. European Journal of Immunology, 2005, 35 (10), pp.2789-92. ⟨10.1002/eji.200535446⟩. ⟨inserm-00336844⟩
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