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Splenic marginal zone B cells in humans: where do they mutate their Ig receptor?

Abstract : Human IgM+ IgD+ CD27+ B cells have mutated Ig genes and harbor a splenic marginal zone (MZ) phenotype. In this issue, the group of R. K?rs has studied the expression of the enzyme activation-induced cytidine deaminase (AID) in human spleen samples by immunocytochemistry and failed to detect a significant AID-expressing subset in the MZ region. The consequences on the possible origin of these cells are discussed.
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https://www.hal.inserm.fr/inserm-00336844
Contributor : Sandra Weller <>
Submitted on : Wednesday, November 5, 2008 - 12:26:17 PM
Last modification on : Friday, March 27, 2020 - 2:21:33 AM
Long-term archiving on: : Tuesday, October 9, 2012 - 3:01:32 PM

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Sandra Weller, Claude-Agnès Reynaud, Jean-Claude Weill. Splenic marginal zone B cells in humans: where do they mutate their Ig receptor?. European Journal of Immunology, Wiley-VCH Verlag, 2005, 35 (10), pp.2789-92. ⟨10.1002/eji.200535446⟩. ⟨inserm-00336844⟩

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