Splenic marginal zone B cells in humans: where do they mutate their Ig receptor?
Abstract
Human IgM+ IgD+ CD27+ B cells have mutated Ig genes and harbor a splenic marginal zone (MZ) phenotype. In this issue, the group of R. K?rs has studied the expression of the enzyme activation-induced cytidine deaminase (AID) in human spleen samples by immunocytochemistry and failed to detect a significant AID-expressing subset in the MZ region. The consequences on the possible origin of these cells are discussed.
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Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
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