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Journal Articles médecine/sciences Year : 2008

[Survivin, the starlet of the passenger protein complex. Check-up for its tenth anniversary.]

Abstract

Ten year after its discovery Survivin has gained a strategic place within the chromosomal passenger complex. Whereas INCENP, Borealin and Aurora B are fully immobile in the complex, Survivin is mobile on centromere. Its mobility is regulated both by phosphorylation and ubiquitination. Survivin is a dynamic messenger that senses the central spindle tension and participates to the control of the mitotic chekpoint. In this review, we have detailed the multiple mitotic activities of Survivin and discussed them in light of the recent reported cristallographic data.

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Genetics
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Origin : Files produced by the author(s)
Origin : Files produced by the author(s)

Thierry Gautier  : Connect in order to contact the contributor

https://www.hal.inserm.fr/inserm-00336277

Submitted on : Monday, November 3, 2008-2:09:04 PM

Last modification on : Thursday, October 13, 2022-3:06:38 PM

Long-term archiving on: Tuesday, September 18, 2012-12:25:51 PM

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Dates and versions

inserm-00336277 , version 1 (03-11-2008)

Identifiers

  • HAL Id : inserm-00336277 , version 1
  • PUBMED : 18950578

Cite

Marlène Delacour-Larose, Thi My Nhung Hoang, Annie Molla. [Survivin, the starlet of the passenger protein complex. Check-up for its tenth anniversary.]. médecine/sciences, 2008, 24 (10), pp.828-32. ⟨inserm-00336277⟩

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