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[Survivin, the starlet of the passenger protein complex. Check-up for its tenth anniversary.]

Marlène Delacour-Larose 1 Thi My Nhung Hoang 1 Annie Molla 2, * 
* Corresponding author
2 INSERM U823, équipe 4 (Chromatine et Epigénétique)
INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
Abstract : Ten year after its discovery Survivin has gained a strategic place within the chromosomal passenger complex. Whereas INCENP, Borealin and Aurora B are fully immobile in the complex, Survivin is mobile on centromere. Its mobility is regulated both by phosphorylation and ubiquitination. Survivin is a dynamic messenger that senses the central spindle tension and participates to the control of the mitotic chekpoint. In this review, we have detailed the multiple mitotic activities of Survivin and discussed them in light of the recent reported cristallographic data.
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Submitted on : Monday, November 3, 2008 - 2:09:04 PM
Last modification on : Monday, February 14, 2022 - 10:20:12 AM
Long-term archiving on: : Tuesday, September 18, 2012 - 12:25:51 PM


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  • HAL Id : inserm-00336277, version 1
  • PUBMED : 18950578



Marlène Delacour-Larose, Thi My Nhung Hoang, Annie Molla. [Survivin, the starlet of the passenger protein complex. Check-up for its tenth anniversary.]. médecine/sciences, EDP Sciences, 2008, 24 (10), pp.828-32. ⟨inserm-00336277⟩



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