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Genetics and epigenetics of 1q rearrangements in hematological malignancies.

A. Fournier 1 A. Florin 1 C. Lefebvre 1, 2 F. Solly 1, 2 D. Leroux 1, 2 Mary Callanan 3, *
* Corresponding author
1 INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
2 Département de cancérologie et d'hématologie
3 INSERM U823, équipe 7 (Voies Oncogéniques Des Hémopathies Malignes)
INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble, Département de cancérologie et d'hématologie
Abstract : Recently, we and others have described a novel class of chromosome aberrations that involves constitutive heterochromatin on human chromosome 1 (cytogenetic band 1q12). These anomalies are particularly frequent in B cell non-Hodgkins lymphoma (NHL) and multiple myeloma (MM) and, remarkably, almost invariably involve partial or total gain of chromosome 1q (including 1q12 heterochromatin) and the formation of novel heterochromatin/euchromatin junctions. This review discusses the pathological significance of these anomalies in light of i) recent integrated gene expression and array comparative genomic hybridisation (aCGH) profiling in MM and ii) increasing evidence of a key role for heterochromatin in the control of normal and pathological gene silencing.
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Submitted on : Wednesday, October 29, 2008 - 2:23:51 PM
Last modification on : Thursday, August 27, 2020 - 11:36:03 AM

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A. Fournier, A. Florin, C. Lefebvre, F. Solly, D. Leroux, et al.. Genetics and epigenetics of 1q rearrangements in hematological malignancies.. Cytogenetic and Genome Researchearch, 2007, 118 (2-4), pp.320-7. ⟨10.1159/000108316⟩. ⟨inserm-00335390⟩

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