Genetics and epigenetics of 1q rearrangements in hematological malignancies. - Archive ouverte HAL Access content directly
Journal Articles Cytogenetic and Genome Researchearch Year : 2007

Genetics and epigenetics of 1q rearrangements in hematological malignancies.

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Abstract

Recently, we and others have described a novel class of chromosome aberrations that involves constitutive heterochromatin on human chromosome 1 (cytogenetic band 1q12). These anomalies are particularly frequent in B cell non-Hodgkins lymphoma (NHL) and multiple myeloma (MM) and, remarkably, almost invariably involve partial or total gain of chromosome 1q (including 1q12 heterochromatin) and the formation of novel heterochromatin/euchromatin junctions. This review discusses the pathological significance of these anomalies in light of i) recent integrated gene expression and array comparative genomic hybridisation (aCGH) profiling in MM and ii) increasing evidence of a key role for heterochromatin in the control of normal and pathological gene silencing.
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inserm-00335390 , version 1 (29-10-2008)

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A. Fournier, A. Florin, C. Lefebvre, F. Solly, D. Leroux, et al.. Genetics and epigenetics of 1q rearrangements in hematological malignancies.. Cytogenetic and Genome Researchearch, 2007, 118 (2-4), pp.320-7. ⟨10.1159/000108316⟩. ⟨inserm-00335390⟩

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