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The increasing role of amphiregulin in non-small cell lung cancer.

Abstract : Non-small cell lung cancers present a 5-year survival rate below 12%. Such a poor prognosis may be explained by non small cell lung cancer cells evasion to apoptosis and resistance to treatments. Amphiregulin, an epidermal growth factor-related growth factor is secreted by non-small cell lung cancer cells in an autocrine/paracrine manner to promote autonomous growth of tumor cells and to provide resistance to apoptosis. Furthermore, amphiregulin is involved in non-small cell lung cancers resistance to epidermal growth factor receptor targeted therapy. This editorial underlines the increasing role of amphiregulin in non-small cell lung cancer cells resistance mechanisms and suggests the use of amphiregulin as a marker for drug sensitivity and/or as a prognostic marker to identify patients that may respond to epidermal growth factor receptor-tyrosine kinase inhibitors.
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https://www.hal.inserm.fr/inserm-00333661
Contributor : Amandine Hurbin <>
Submitted on : Thursday, October 23, 2008 - 5:10:56 PM
Last modification on : Friday, November 6, 2020 - 4:12:02 AM
Long-term archiving on: : Monday, June 7, 2010 - 7:51:15 PM

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Benoît Busser, Jean-Luc Coll, Amandine Hurbin. The increasing role of amphiregulin in non-small cell lung cancer.. Pathologie Biologie, Elsevier Masson, 2009, 57 (7-8), pp.511-2. ⟨10.1016/j.patbio.2008.10.002⟩. ⟨inserm-00333661⟩

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