3-D analysis of cortical morphometry in differential diagnosis of Parkinson's plus syndromes: mapping frontal lobe cortical atrophy in progressive supranuclear palsy patients.

Duygu Tosun 1, * Simon Duchesne 1 Yan Rolland 2 Arthur Toga 3 Marc Vérin 4 Christian Barillot 5
* Corresponding author
5 VisAGeS - Vision, Action et Gestion d'informations en Santé
INSERM - Institut National de la Santé et de la Recherche Médicale : U746, Inria Rennes – Bretagne Atlantique , IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE
Abstract : With the ability to study brain anatomy in vivo using magnetic resonance imaging, studies on regional brain atrophy suggest possible improvements for differential diagnosis of movement disorders with parkinsonian symptoms. In this study, we investigate effects of different parkinsonian syndromes on the cortical gray matter thickness and the geometric shape of the cerebral cortex. The study consists of a total of 24 patients with a diagnosis of probable progressive supranuclear palsy (PSP), multiple systems atrophy (MSA) or idiopathic Parkinson's disease (IPD). We examine dense estimates of cortical gray matter thickness, sulcal depth, and measures of the curvature in a surface-based cortical morphometry analysis framework. Group difference results indicate higher cortical atrophy rate in the frontal lobe in PSP patients when compared to either MSA or IPD. These findings are indicative of the potential use of routine MRI and cortical morphometry in performing differential diagnosis in PSP, MSA and IPD.
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  • HAL Id : inserm-00333468, version 1
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Duygu Tosun, Simon Duchesne, Yan Rolland, Arthur Toga, Marc Vérin, et al.. 3-D analysis of cortical morphometry in differential diagnosis of Parkinson's plus syndromes: mapping frontal lobe cortical atrophy in progressive supranuclear palsy patients.. Medical image computing and computer-assisted intervention : MICCAI .. International Conference on Medical Image Computing and Computer-Assisted Intervention, Springer, 2007, 10 (Pt 2), pp.891-9. ⟨inserm-00333468⟩

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