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Activatable probes for non invasive small animal fluorescence imaging

Abstract : Fluorescence tomography today appears as a complementary imaging modality for assessing molecular processes in small living animals. A new design of fluorescent activatable units for the imaging of cellular internalization of probes is proposed. Disulfide bridges are used as intracellular cleavable bounds for fluorescence activation. These units are not activated in blood, neither in vitro nor in mouse, but specifically in the presence of lysed cells or a chemical reducer. We therefore expect that the use of such activatable units, grafted to targeting moieties, will improve significantly the contrast of images obtained in the future.
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https://www.hal.inserm.fr/inserm-00331940
Contributor : Amandine Hurbin <>
Submitted on : Monday, October 20, 2008 - 10:27:19 AM
Last modification on : Tuesday, November 17, 2020 - 8:42:05 AM
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  • HAL Id : inserm-00331940, version 1

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CNRS | CEA | U823 | DRT | LETI | CEA-GRE | UGA

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Isabelle Texier, Jesus Razkin, Veronique Josserand, Didier Boturyn, Pascal Dumy, et al.. Activatable probes for non invasive small animal fluorescence imaging. Nuclear Instruments and Methods in Physics Research, Elsevier, 2007, 571, pp.165-168. ⟨inserm-00331940⟩

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