U. Klein, R. Kuppers, and K. Rajewsky, Evidence for a large compartment of IgM-expressing memory B cells in humans, Blood, vol.89, pp.1288-1298, 1997.

U. Klein, K. Rajewsky, and R. Kuppers, Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells, The Journal of Experimental Medicine, vol.154, issue.9, pp.1679-1689, 1998.
DOI : 10.1038/ng0193-88

R. Carsetti, M. M. Rosado, and H. Wardmann, Peripheral development of B cells in mouse and man, Immunological Reviews, vol.210, issue.1, pp.179-191, 2004.
DOI : 10.1038/416603a

A. K. Cuss, D. T. Avery, J. L. Cannons, L. J. Yu, K. E. Nichols et al., Expansion of Functionally Immature Transitional B Cells Is Associated with Human-Immunodeficient States Characterized by Impaired Humoral Immunity, The Journal of Immunology, vol.176, issue.3, pp.1506-1516, 2006.
DOI : 10.4049/jimmunol.176.3.1506

G. P. Sims, R. Ettinger, Y. Shirota, C. H. Yarboro, G. G. Illei et al., Identification and characterization of circulating human transitional B cells, Blood, vol.105, issue.11, pp.4390-4398, 2005.
DOI : 10.1182/blood-2004-11-4284

C. Wei, J. Anolik, A. Cappione, B. Zheng, A. Pugh-bernard et al., A New Population of Cells Lacking Expression of CD27 Represents a Notable Component of the B Cell Memory Compartment in Systemic Lupus Erythematosus, The Journal of Immunology, vol.178, issue.10, pp.6624-6633, 2007.
DOI : 10.4049/jimmunol.178.10.6624

S. Wirths and A. Lanzavecchia, ABCB1 transporter discriminates human resting naive B???cells from cycling transitional and memory B???cells, European Journal of Immunology, vol.2, issue.12, pp.3433-3441, 2005.
DOI : 10.1002/eji.200535364

J. F. Fecteau, G. Cote, and S. Neron, A New Memory CD27-IgG+ B Cell Population in Peripheral Blood Expressing VH Genes with Low Frequency of Somatic Mutation, The Journal of Immunology, vol.177, issue.6, pp.3728-3736, 2006.
DOI : 10.4049/jimmunol.177.6.3728

A. Nilsson, A. De-milito, F. Mowafi, G. Winberg, O. Bjork et al., Expression of CD27???CD70 on Early B Cell Progenitors in the Bone Marrow: Implication for Diagnosis and Therapy of Childhood ALL, Experimental Hematology, vol.33, issue.12, pp.1500-1507, 2005.
DOI : 10.1016/j.exphem.2005.10.005

K. Mihara, T. Tsujimoto, and A. Kuramoto, Identifi cation of early plasma cells in peripheral blood and their clinical signifi cance, 1996.

L. Galibert, N. Burdin, B. De-saint-vis, P. Garrone, C. Van-kooten et al., CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype, Journal of Experimental Medicine, vol.183, issue.1, pp.77-85, 1996.
DOI : 10.1084/jem.183.1.77

M. Yamada, R. Wasserman, B. A. Reichard, S. Shane, A. J. Caton et al., Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes, Journal of Experimental Medicine, vol.173, issue.2, pp.395-407, 1991.
DOI : 10.1084/jem.173.2.395

Y. Levy, N. Gupta, F. Le-deist, C. Garcia, A. Fischer et al., Defect in IgV gene somatic hypermutation in common variable immuno-defi ciency syndrome, Proc. Natl. Acad. Sci. USA, pp.13135-13140, 1998.

M. Muramatsu, K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai et al., Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme, Cell, vol.102, issue.5, pp.553-563, 2000.
DOI : 10.1016/S0092-8674(00)00078-7

P. Revy, T. Muto, Y. Levy, F. Geissmann, A. Plebani et al., Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2), Cell, vol.102, issue.5, pp.565-575, 2000.
DOI : 10.1016/S0092-8674(00)00079-9

B. H. Ye, G. Cattoretti, Q. Shen, J. Zhang, N. Hawe et al., The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation, Nature Genetics, vol.177, issue.2, pp.161-170, 1997.
DOI : 10.1016/0092-8674(91)90011-M

J. H. Han, S. Akira, K. Calame, B. Beutler, E. Selsing et al., Class Switch Recombination and Somatic Hypermutation in Early Mouse B Cells Are Mediated by B Cell and Toll-like Receptors, Immunity, vol.27, issue.1, pp.64-75, 2007.
DOI : 10.1016/j.immuni.2007.05.018

Y. Ueda, D. Liao, K. Yang, A. Patel, and G. Kelsoe, T-Independent Activation-Induced Cytidine Deaminase Expression, Class-Switch Recombination, and Antibody Production by Immature/Transitional 1 B Cells, The Journal of Immunology, vol.178, issue.6, pp.3593-3601, 2007.
DOI : 10.4049/jimmunol.178.6.3593

A. Zandvoort, M. E. Lodewijk, N. K. De-boer, P. M. Dammers, F. G. Kroese et al., CD27 expression in the human splenic marginal zone: the infant marginal zone is populated by naive B cells, Tissue Antigens, vol.58, issue.4, pp.234-242, 2001.
DOI : 10.1034/j.1399-0039.2001.580403.x

J. Spencer, M. E. Perry, and D. K. Dunn-walters, Human marginal-zone B cells, Immunology Today, vol.19, issue.9, pp.421-426, 1998.
DOI : 10.1016/S0167-5699(98)01308-5

W. Timens, A. Boes, T. Rozeboom-uiterwijk, and S. Poppema, Immaturity of the human splenic marginal zone in infancy. Possible contribution to the defi cient infant immune response, J. Immunol, vol.143, pp.3200-3206, 1989.

A. Lim, B. Lemercier, X. Wertz, S. L. Pottier, F. Huetz et al., Many human peripheral VH5-expressing IgM+ B cells display a unique heavy-chain rearrangement, International Immunology, vol.20, issue.1, pp.105-116, 2008.
DOI : 10.1093/intimm/dxm125

URL : https://hal.archives-ouvertes.fr/pasteur-00319682

L. J. Mcheyzer-williams, L. P. Malherbe, and M. G. Mcheyzer-williams, Checkpoints in memory B-cell evolution, Immunological Reviews, vol.272, issue.1, pp.255-268, 2006.
DOI : 10.1126/science.1076071

Y. J. Liu, F. Malisan, O. De-bouteiller, C. Guret, S. Lebecque et al., Within Germinal Centers, Isotype Switching of Immunoglobulin Genes Occurs after the Onset of Somatic Mutation, Immunity, vol.4, issue.3, pp.241-250, 1996.
DOI : 10.1016/S1074-7613(00)80432-X

H. White and D. Gray, Analysis of Immunoglobulin (Ig) Isotype Diversity and Igm/D Memory in the Response to Phenyl-Oxazolone, The Journal of Experimental Medicine, vol.25, issue.12, 2000.
DOI : 10.1002/eji.1830170414

M. Vaskova, E. Mejstrikova, T. Kalina, P. Martinkova, M. Omelka et al., Transfer of genomics information to flow cytometry: expression of CD27 and CD44 discriminates subtypes of acute lymphoblastic leukemia, Leukemia, vol.97, issue.5, pp.876-878, 2005.
DOI : 10.1038/sj.leu.2403706

S. G. Tangye and K. L. Good, Human IgM+CD27+ B Cells: Memory B Cells or "Memory" B Cells?, The Journal of Immunology, vol.179, issue.1, pp.13-19, 2007.
DOI : 10.4049/jimmunol.179.1.13

S. Weller, M. C. Braun, B. K. Tan, A. Rosenwald, C. Cordier et al., Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire, Blood, vol.104, issue.12, pp.3647-3654, 2004.
DOI : 10.1182/blood-2004-01-0346

URL : https://hal.archives-ouvertes.fr/inserm-00338311

S. Weller, A. Faili, C. Garcia, M. C. Braun, F. F. Le-deist et al., CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversifi cation pathway in humans, Proc. Natl. Acad. Sci. USA, pp.1166-1170, 2001.

K. Agematsu, H. Nagumo, K. Shinozaki, S. Hokibara, K. Yasui et al., Absence of IgD-CD27(+) memory B cell population in X-linked hyper-IgM syndrome., Journal of Clinical Investigation, vol.102, issue.4, pp.853-860, 1998.
DOI : 10.1172/JCI3409

H. P. Brezinschek, T. Dorner, N. L. Monson, R. I. Brezinschek, and P. E. Lipsky, The influence of CD40-CD154 interactions on the expressed human VH repertoire: analysis of VH genes expressed by individual B cells of a patient with X-linked hyper-IgM syndrome, International Immunology, vol.12, issue.6, pp.767-775, 2000.
DOI : 10.1093/intimm/12.6.767

K. Warnatz, L. Bossaller, U. Salzer, A. Skrabl-baumgartner, W. Schwinger et al., Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiency, Blood, vol.107, issue.8, pp.3045-3052, 2006.
DOI : 10.1182/blood-2005-07-2955

D. Sabatino, A. , M. M. Rosado, R. Ciccocioppo, P. Cazzola et al., Depletion of Immunoglobulin M Memory B Cells is Associated with Splenic Hypofunction in Inflammatory Bowel Disease, The American Journal of Gastroenterology, vol.170, issue.8, pp.1788-1795, 2005.
DOI : 10.1038/nri799

S. Kruetzmann, M. M. Rosado, H. Weber, U. Germing, O. Tournilhac et al., Infections Are Generated in the Spleen, The Journal of Experimental Medicine, vol.1, issue.7, pp.939-945, 2003.
DOI : 10.1016/S0041-1345(97)00043-2

M. Takizawa, K. Sugane, and K. Agematsu, Role of Tonsillar IgD+CD27+ Memory B Cells in Humoral Immunity Against Pneumococcal Infection, Human Immunology, vol.67, issue.12, pp.966-975, 2006.
DOI : 10.1016/j.humimm.2006.10.008

K. Willenbrock, B. Jungnickel, M. L. Hansmann, and R. Kuppers, Human splenic marginal zone B???cells lack expression of activation-induced cytidine deaminase, European Journal of Immunology, vol.29, issue.10, pp.3002-3007, 2005.
DOI : 10.1002/eji.200535134

C. S. Ma, S. Pittaluga, D. T. Avery, N. J. Hare, I. Maric et al., Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease, Journal of Clinical Investigation, vol.116, issue.2, pp.322-333, 2006.
DOI : 10.1172/JCI25720

K. M. Toellner, W. E. Jenkinson, D. R. Taylor, M. Khan, D. M. Sze et al., Low-level Hypermutation in T Cell???independent Germinal Centers Compared with High Mutation Rates Associated with T Cell???dependent Germinal Centers, The Journal of Experimental Medicine, vol.35, issue.3, pp.383-389, 2002.
DOI : 10.1073/pnas.98.3.1166

K. Bauer, M. Zemlin, M. Hummel, S. Pfeiff-er, J. Karstaedt et al., Diversification of Ig Heavy Chain Genes in Human Preterm Neonates Prematurely Exposed to Environmental Antigens, The Journal of Immunology, vol.169, issue.3, pp.1349-1356, 2002.
DOI : 10.4049/jimmunol.169.3.1349

A. Zandvoort and W. Timens, The dual function of the splenic marginal zone: essential for initiation of anti-TI-2 responses but also vital in the general first-line defense against blood-borne antigens, Clinical and Experimental Immunology, vol.26, issue.1, pp.4-11, 2002.
DOI : 10.1093/intimm/9.1.27

C. Pannetier, J. Even, and P. Kourilsky, T-cell repertoire diversity and clonal expansions in normal and clinical samples, Immunology Today, vol.16, issue.4, pp.176-181, 1995.
DOI : 10.1016/0167-5699(95)80117-0

W. Holtmeier, A. Hennemann, and W. F. Caspary, IgA and IgM VH repertoires in human colon: Evidence for clonally expanded B cells that are widely disseminated, Gastroenterology, vol.119, issue.5, pp.1253-1266, 2000.
DOI : 10.1053/gast.2000.20219

J. E. Shepherd and . Crowe-jr, Evidence for preferential Ig gene usage and diff erential TdT and exonuclease activities in human naive and memory B cells, Mol. Immunol, vol.44, pp.2173-2183, 2007.

A. H. Lucas, K. D. Moulton, V. R. Tang, and D. C. Reason, Combinatorial Library Cloning of Human Antibodies to Streptococcus pneumoniae Capsular Polysaccharides: Variable Region Primary Structures and Evidence for Somatic Mutation of Fab Fragments Specific for Capsular Serotypes 6B, 14, and 23F, Infection and Immunity, vol.69, issue.2, pp.853-864, 2001.
DOI : 10.1128/IAI.69.2.853-864.2001

F. Martin and J. F. Kearney, MARGINAL-ZONE B CELLS, Nature Reviews Immunology, vol.182, issue.5, pp.323-335, 2002.
DOI : 10.1016/S0167-5699(98)01308-5

Y. Shi, K. Agematsu, H. D. Ochs, and K. Sugane, Functional analysis of human memory B-cell subpopulations: IgD+CD27+ B cells are crucial in secondary immune response by producing high affinity IgM, Clinical Immunology, vol.108, issue.2, pp.128-137, 2003.
DOI : 10.1016/S1521-6616(03)00092-5

K. Rosner, D. B. Winter, R. E. Tarone, G. L. Skovgaard, V. A. Bohr et al., Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes, Immunology, vol.156, issue.2, pp.179-187, 2001.
DOI : 10.1016/S0167-5699(00)01714-X

M. Tsuiji, S. Yurasov, K. Velinzon, S. Thomas, M. C. Nussenzweig et al., memory B cell development, The Journal of Experimental Medicine, vol.143, issue.2, pp.393-400, 2006.
DOI : 10.1172/JCI24387

P. M. Dammers, A. Visser, E. R. Popa, P. Nieuwenhuis, and F. G. Kroese, Most Marginal Zone B Cells in Rat Express Germline Encoded Ig VH Genes and Are Ligand Selected, The Journal of Immunology, vol.165, issue.11, pp.6156-6169, 2000.
DOI : 10.4049/jimmunol.165.11.6156

R. L. Schelonka, J. Tanner, Y. Zhuang, G. L. Gartland, M. Zemlin et al., Categorical selection of the antibody repertoire in splenic B cells, European Journal of Immunology, vol.399, issue.4, pp.1010-1021, 2007.
DOI : 10.1002/eji.200636569

H. Wardemann, S. Yurasov, A. Schaefer, J. W. Young, E. Meff et al., Predominant Autoantibody Production by Early Human B Cell Precursors, Science, vol.301, issue.5638, pp.1374-1377, 2003.
DOI : 10.1126/science.1086907

S. Pillai, A. Cariappa, and S. T. Moran, Positive selection and lineage commitment during peripheral B-lymphocyte development, Immunological Reviews, vol.171, issue.1, pp.206-218, 2004.
DOI : 10.1074/jbc.M301575200

S. Pillai, A. Cariappa, and S. T. Moran, MARGINAL ZONE B CELLS, Annual Review of Immunology, vol.23, issue.1, pp.161-196, 2005.
DOI : 10.1146/annurev.immunol.23.021704.115728

J. C. Weill and C. A. Reynaud, Do developing B cells need antigen?: Figure 1., The Journal of Experimental Medicine, vol.136, issue.1, pp.7-9, 2005.
DOI : 10.1016/S1074-7613(00)00006-6

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212778

D. K. Lanning, K. J. Rhee, and K. L. Knight, Intestinal bacteria and development of the B-lymphocyte repertoire, Trends in Immunology, vol.26, issue.8, pp.419-425, 2005.
DOI : 10.1016/j.it.2005.06.001

K. J. Rhee, P. J. Jasper, P. Sethupathi, M. Shanmugam, D. Lanning et al., Positive selection of the peripheral B cell repertoire in gut-associated lymphoid tissues, The Journal of Experimental Medicine, vol.162, issue.1, pp.55-62, 2005.
DOI : 10.1016/S1074-7613(02)00270-4

L. Wen, J. Brill-dashoff, S. A. Shinton, M. Asano, R. R. Hardy et al., Evidence of Marginal-Zone B Cell- Positive Selection in Spleen, Immunity, vol.23, issue.3, pp.297-308, 2005.
DOI : 10.1016/j.immuni.2005.08.007

H. Song and J. Cerny, Functional Heterogeneity of Marginal Zone B Cells Revealed by Their Ability to Generate Both Early Antibody-forming Cells and Germinal Centers with Hypermutation and Memory in Response to a T-dependent Antigen, The Journal of Experimental Medicine, vol.9, issue.12, pp.1923-1935, 2003.
DOI : 10.1084/jem.176.3.679