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Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+ IgD+ CD27+ B cell repertoire in infants.

Abstract : T cell-dependent immune responses develop soon after birth, whereas it takes 2 yr for humans to develop T cell-independent responses. We used this dissociation to analyze the repertoire diversification of IgM(+)IgD(+)CD27(+) B cells (also known as "IgM memory" B cells), comparing these cells with switched B cells in children <2 yr of age, with the aim of determining whether these two subsets are developmentally related. We show that the repertoire of IgM(+)IgD(+)CD27(+) B cells in the spleen and blood displays no sign of antigen-driven activation and expansion on H-CDR3 spectratyping, despite the many antigenic challenges provided by childhood vaccinations. This repertoire differed markedly from those of switched B cells and splenic germinal center B cells, even at the early stage of differentiation associated with mu heavy chain expression. These data provide evidence for the developmental diversification of IgM(+)IgD(+)CD27(+) B cells, at least in very young children, outside of T cell-dependent and -independent immune responses.
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https://www.hal.inserm.fr/inserm-00331378
Contributor : Sandra Weller <>
Submitted on : Thursday, October 16, 2008 - 2:32:46 PM
Last modification on : Wednesday, August 19, 2020 - 11:16:37 AM
Long-term archiving on: : Monday, June 7, 2010 - 8:18:43 PM

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Sandra Weller, Maria Mamani-Matsuda, Capucine Picard, Corinne Cordier, Damiana Lecoeuche, et al.. Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+ IgD+ CD27+ B cell repertoire in infants.. The Journal of Experimental Medecine, The Rockefeller University Press, 2008, 205 (6), pp.1331-42. ⟨10.1084/jem.20071555⟩. ⟨inserm-00331378⟩

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