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Journal Articles Liver Transplantation Year : 2009

Hepatocyte transplantation in animal models.

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Abstract

More than 30 years after the first hepatocyte transplant to treat the Gunn rat, the animal model for Crigler-Najjar syndrome, there are still a number of impediments to hepatocyte transplantation. Numerous animal models are still used in work aimed at improving hepatocyte engraftment and/or long-term function. Although other cell sources, particularly hepatic and extrahepatic stem cells, are being explored, adult hepatocytes remain the cells of choice for the treatment of liver diseases by cell therapy. In recent years, diverse approaches have been developed in various animal models to enhance hepatocyte transduction and amplification in vitro and cell engraftment and functionality in vivo. They have led to significant progress in hepatocyte transplantation for the treatment of patients with metabolic diseases and for bridging patients with acute injury until their own livers regenerate. This review presents and considers the results of this work with a special emphasis on procedures that might be clinically applicable.

Dates and versions

inserm-00326132 , version 1 (01-10-2008)

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Anne Weber, Marie-Thérèse Groyer-Picard, Dominique Franco, Ibrahim Dagher. Hepatocyte transplantation in animal models.: Hepatocyte transplantation in animals models. Liver Transplantation, 2009, 15 (1), pp.7-14. ⟨10.1002/lt.21670⟩. ⟨inserm-00326132⟩
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