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Cytoreductive partial nephrectomy does not undermine cancer control in metastatic renal cell carcinoma: a population-based study.

Abstract : OBJECTIVES: We examined the population-based rates of cancer-specific survival in patients with metastatic renal cell carcinoma (MRCC) treated with either partial (PN) or radical cytoreductive nephrectomy (RN). METHODS: Patients diagnosed with MRCC and treated with either PN or RN were identified within nine SEER cancer registries. Matched and unmatched Kaplan-Meier survival analyses, as well as multivariable Cox regression models compared the effect of RN (n = 1997, 97.8%) vs. PN (n = 46, 2.2%) on cancer-specific survival (CSS). Covariates consisted of age, gender, community type (rural vs urban), race, Surveillance, Epidemiology, and End Results (SEER) registry, tumor size and year of diagnosis. RESULTS: In multivariable unmatched Cox regression analyses, no statistically significantly difference was found in CSS between the two groups (hazard ratio [HR] 1.40, P = .16). Similarly, no difference in CSS was found in the matched analyses (HR 1.35, log rank P = .34). CONCLUSION: Cytoreductive PN does not appear to undermine survival in patients with MRCC.
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https://www.hal.inserm.fr/inserm-00325530
Contributor : Hervé de Villemeur <>
Submitted on : Monday, September 29, 2008 - 3:34:56 PM
Last modification on : Monday, July 20, 2020 - 12:34:50 PM

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Umberto Capitanio, Laurent Zini, Paul Perrotte, Shahrokh Shariat, Claudio Jeldres, et al.. Cytoreductive partial nephrectomy does not undermine cancer control in metastatic renal cell carcinoma: a population-based study.. Urology, Elsevier, 2008, 72 (5), pp.1090-5. ⟨10.1016/j.urology.2008.06.059⟩. ⟨inserm-00325530⟩

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