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One or two enzyme-linked immunosorbent assay tests on the first serum sample for initial diagnosis of HIV-1 infection?

Dominique Costagliola 1, 2 Florence Damond 3, 4 Pierre Palmer 5 Christine Rouzioux 6, 7 Francoise Brun-Vézinet 3, 4
1 Epidémiologie Clinique et Traitement de l'Infection à VIH
2 Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière]
3 Laboratoire de Virologie
4 Recherche Antivirale
5 Laboratoire de Virologie
6 Laboratoire de Virologie [CHU Necker]
7 Infections à Vih, Réservoirs, Pharmacologie des Antirétroviraux et Prévention de la Transmission Mère Enfant
Abstract : In France, the first sample for the initial diagnosis of HIV-1 infection must be tested with two antibody assays: one being an enzyme-linked immunosorbent assay. If one is positive, confirmation tests are performed. We evaluated the performance of initial diagnostic strategies based on the use of one versus two enzyme-linked immunosorbent assay tests, either an antigen-antibody test or a simple antibody assay. We found that a single antigen-antibody test was more efficient than a combination of the two tests.
keyword : HIV diagnosis ELISA
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https://www.hal.inserm.fr/inserm-00321930
Contributor : Dominique Costagliola <>
Submitted on : Tuesday, September 16, 2008 - 1:41:06 PM
Last modification on : Thursday, December 10, 2020 - 3:38:41 AM

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INSERM | UNIV-PARIS7 | UNIV-PARIS5 | UPMC | USPC | SORBONNE-UNIVERSITE | UNIV-PARIS

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Dominique Costagliola, Florence Damond, Pierre Palmer, Christine Rouzioux, Francoise Brun-Vézinet. One or two enzyme-linked immunosorbent assay tests on the first serum sample for initial diagnosis of HIV-1 infection?. AIDS, Lippincott, Williams & Wilkins, 2008, 22 (15), pp.2042-4. ⟨10.1097/QAD.0b013e328311869f⟩. ⟨inserm-00321930⟩

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