W. Thompson, G. Longstreth, D. Drossman, K. Heaton, E. Irvine et al., Functional bowel disorders and functional abdominal pain, Gut, vol.45, issue.Supplement 2, pp.43-50, 1999.
DOI : 10.1136/gut.45.2008.ii43

M. Amouretti, L. Pen, C. Gaudin, A. Bommelaer, G. Frexinos et al., Impact of irritable bowel syndrome (IBS) on health-related quality of life (HRQOL), Gastroent??rologie Clinique et Biologique, vol.30, issue.2, pp.241-247, 2006.
DOI : 10.1016/S0399-8320(06)73160-8

M. Bouin, V. Plourde, M. Boivin, M. Riberdy, F. Lupien et al., Rectal distention testing in patients with irritable bowel syndrome: Sensitivity, specificity, and predictive values of pain sensory thresholds, Gastroenterology, vol.122, issue.7, pp.1771-1778, 2002.
DOI : 10.1053/gast.2002.33601

D. Kumar and D. Wingate, Irritable bowel syndrome: a paroxysmal motor disorder, Lancet, vol.1, pp.620-621, 1986.

J. Kellow, S. Phillips, L. Miller, and A. Zinsmeister, Dysmotility of the small intestine in irritable bowel syndrome., Gut, vol.29, issue.9, pp.1236-1279, 1988.
DOI : 10.1136/gut.29.9.1236

D. Gorard, G. Libby, and M. Farthing, Ambulatory small intestinal motility in 'diarrhoea' predominant irritable bowel syndrome., Gut, vol.35, issue.2, pp.203-213, 1994.
DOI : 10.1136/gut.35.2.203

J. Kellow and S. Phillips, Altered small bowel motility in irritable bowel syndrome is correlated with symptoms, Gastroenterology, vol.92, issue.6, pp.1885-93, 1987.
DOI : 10.1016/0016-5085(87)90620-2

R. Spiller, Disturbances in large bowel motility, Best Practice & Research Clinical Gastroenterology, vol.13, issue.3, pp.397-413, 1999.
DOI : 10.1053/bega.1999.0035

D. Kumar, P. Thompson, D. Wingate, C. Vesselinova-jenkins, and G. Libby, Abnormal REM sleep in the irritable bowel syndrome, Gastroenterology, vol.103, issue.1, pp.12-19, 1992.
DOI : 10.1016/0016-5085(92)91089-M

M. Delvaux, Alterations of sensori-motor functions of the digestive tract in the pathophysiology of irritable bowel syndrome, Best Practice & Research Clinical Gastroenterology, vol.18, issue.4, pp.747-71, 2004.
DOI : 10.1016/j.bpg.2004.06.004

S. Lissner, R. Spiller, J. Tack, and P. Whorwell, Clinical trial guidelines for pharmacological treatment of irritable bowel syndrome Committee for Proprietary Medicinal Products (CPMP). Points to consider on the evaluation of medicinal products for the treatment of irritable bowel syndrome, Aliment Pharmacol Ther, vol.18, issue.12, pp.569-80, 2003.

R. Spiller, Problems and challenges in the design of irritable bowel syndrome clinical trials: experience from published trials, The American Journal of Medicine, vol.107, issue.5, pp.91-98, 1999.
DOI : 10.1016/S0002-9343(99)00086-8

R. Lipman and L. Covi, Outpatient treatment of neurotic depression: medication and group psychotherapy, Evaluation of the psychological therapies

R. Akehurst and E. Kaltenthaler, Treatment of irritable bowel syndrome: a review of randomised controlled trials, Gut, vol.48, issue.2, pp.272-82, 2001.
DOI : 10.1136/gut.48.2.272

B. Hahn, M. Watson, S. Yan, D. Gunput, and J. Heuijerjans, Irritable bowel syndrome symptom patterns: frequency, duration, and severity, Digestive Diseases and Sciences, vol.43, issue.12, pp.2715-2723, 1998.
DOI : 10.1023/A:1026663613695

K. Tillisch, J. Labus, B. Naliboff, R. Bolus, M. Shetzline et al., Characterization of the Alternating Bowel Habit Subtype in Patients with Irritable Bowel Syndrome, The American Journal of Gastroenterology, vol.109, issue.4, pp.896-904, 2005.
DOI : 10.1046/j.1365-2036.2001.01010.x

M. Camilleri, Management of the irritable bowel syndrome, Gastroenterology, vol.120, issue.3, pp.652-68, 2001.
DOI : 10.1053/gast.2001.21908

S. Zanten, Design of treatment trials for functional gastrointestinal disorders, Gut, vol.45, issue.Supplement 2
DOI : 10.1136/gut.45.2008.ii69

T. Poynard, S. Naveau, B. Mory, and J. Chaput, Meta-analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome, Alimentary Pharmacology & Therapeutics, vol.33, issue.5, pp.499-510, 1994.
DOI : 10.1111/j.1365-2036.1994.tb00322.x

T. Poynard, C. Regimbeau, and Y. Benhamou, Meta-analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome, Alimentary Pharmacology and Therapeutics, vol.45, issue.3, pp.355-61, 2001.
DOI : 10.1016/0197-2456(86)90046-2

J. Jailwala, T. Imperiale, and K. Kroenke, Pharmacologic Treatment of the Irritable Bowel Syndrome, Annals of Internal Medicine, vol.133, issue.2, pp.136-183, 2000.
DOI : 10.7326/0003-4819-133-2-200007180-00013

O. Chassany, P. Le-jeunne, M. Duracinsky, M. Schwalm, and M. Mathieu, Discrepancies between Patient-Reported Outcomes and Clinician-Reported Outcomes in Chronic Venous Disease, Irritable Bowel Syndrome, and Peripheral Arterial Occlusive Disease, Value in Health, vol.9, issue.1, pp.39-46, 2006.
DOI : 10.1111/j.1524-4733.2006.00079.x

K. Bardhan, G. Bodemer, H. Geldof, E. Scutz, A. Health et al., A double-blind, randomized, placebo-controlled dose-ranging study to evaluate the efficacy of alosetron in the treatment of irritable bowel syndrome, Alimentary Pharmacology and Therapeutics, vol.38, issue.1, pp.23-34, 2000.
DOI : 10.1046/j.1365-2036.1999.00610.x

M. Pitz, M. Bernstein, and C. , Defining the predictors of the placebo response in irritable bowel syndrome, Clinical Gastroenterology and Hepatology, vol.3, issue.3, pp.237-284, 2005.
DOI : 10.1016/S1542-3565(04)00626-3

J. Park, E. Kelly, E. Jacobson, C. Kerr, and A. Lembo, The placebo effect in irritable bowel syndrome trials: a meta-analysis, Neurogastroenterol Motil, vol.17, pp.332-372, 2005.

A. Quartero, V. Meineche-schmidt, J. Muris, G. Rubin, N. De-wit et al., Bulking agents, antispasmodic and antidepressant medication for the treatment of irritable bowel syndrome, EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT), pp.669-81, 2005.

J. Frexinos, P. Rusniewski, E. Hasnaoui, and A. , Prevalence of irritable bowel syndrome (IBS) and variability of diagnostic criteria, Gastroenterol Clin Biol, vol.28, pp.554-61, 2004.

P. Ducrotte, B. Flourié, M. Lemann, A. Lepicard, and O. Reigneau, Irritable bowel syndrome in
URL : https://hal.archives-ouvertes.fr/inserm-00410559

. France, a common, debilitating and costly disorder, Eur J Gastroenterol Hepatol, vol.16, pp.995-1001, 2004.