Adherence to antiretroviral therapy in patients enrolled in a comprehensive care program in Cambodia: a 24-month follow-up assessment. - Archive ouverte HAL Access content directly
Journal Articles Antiviral Therapy Year : 2008

Adherence to antiretroviral therapy in patients enrolled in a comprehensive care program in Cambodia: a 24-month follow-up assessment.

(1) , (1) , (2, 3) , (1) , (2) , (3) , (2) , (3, 4) , (5) , (3, 6)
1
2
3
4
5
6

Abstract

BACKGROUND: The long-term maintenance of antiretroviral therapy (ART) remains an important issue, especially in limited-resource settings where additional barriers exist. A cross-sectional study was performed 24 months after ART initiation for patients treated in Cambodia in order to estimate the prevalence and identify determinants of non-adherence. METHODS: Adults receiving ART for 24 +/- 2 months were considered eligible for the study. Self-reported non-adherence was defined according to an algorithm based on six items. The questionnaire also assessed ART-related side effects and HIV disclosure. HIV-1 RNA plasma viral load was measured using real-time PCR. Multivariate rare events logistic regression analysis was used to identify independent factors associated with non-adherence. RESULTS: A total of 346 patients participated in the study. At 24 months, 95% of patients were adherent, 80% had HIV RNA <40 copies/ml and 75% had CD4+ T-cell counts >200 cells/mm3. Virological success was significantly higher in adherent patients than in non-adherent patients (81% versus 56%, P=0.021). Living in a rural area, limited HIV disclosure and perceived lipodystrophy were independently associated with non-adherence. CONCLUSIONS: At 24 months, adherence to ART was high and explained positive virological outcomes. In order to maintain adherence and long-term virological benefits, special attention should be given to patients living in rural areas, those with lipodystrophy-related symptoms and others who express difficulties disclosing their condition to close family members.
Fichier principal
Vignette du fichier
FINAL_MANUSCRIPT_R3.pdf (96.88 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-00320461 , version 1 (11-09-2008)

Identifiers

  • HAL Id : inserm-00320461 , version 1
  • PUBMED : 18771053

Cite

Bruno Spire, Patrizia Carrieri, Pal Sopha, Camelia Protopopescu, Narom Prak, et al.. Adherence to antiretroviral therapy in patients enrolled in a comprehensive care program in Cambodia: a 24-month follow-up assessment.. Antiviral Therapy, 2008, 13 (5), pp.697-703. ⟨inserm-00320461⟩
213 View
432 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More