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Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.

Abstract : Stereoisomers of 1-amino-2-phosphonomethylcyclopropanecarboxylic acid (APCPr), conformationally restricted analogues of L-AP4 (2-amino-4-phosphonobutyric acid), have been prepared and evaluated at recombinant group III metabotropic glutamate receptors. They activate these receptors over a broad range of potencies. The most potent isomer (1S,2R)-APCPr displays a similar pharmacological profile as that of L-AP4 (EC50 0.72, 1.95, >500, 0.34 microM at mGlu4, 6, 7, 8 receptors, respectively, and no effect at group I/II mGluRs). It was characterized on native receptors located in the basal ganglia (BG) where it induced a robust and reversible inhibition of synaptic transmission. It was tested in vivo in haloperidol-induced catalepsy, a model of Parkinsonian akinesia, by direct infusion in the globus pallidus of the BG. At a dose of 0.5 nmol/microL, catalepsy was significantly antagonized. This study reveals that (1S,2R)-APCPr is a potent group III mGluR agonist and confirms that these receptors may be considered as a therapeutic target in the Parkinson's disease.
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https://www.hal.inserm.fr/inserm-00318976
Contributor : Cyril Goudet <>
Submitted on : Friday, September 5, 2008 - 5:11:37 PM
Last modification on : Tuesday, September 22, 2020 - 3:57:55 AM
Long-term archiving on: : Saturday, November 26, 2016 - 1:19:49 AM

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Pauline Sibille, Sébastien Lopez, Isabelle Brabet, Ornella Valenti, Nadia Oueslati, et al.. Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.. Journal of Medicinal Chemistry, American Chemical Society, 2007, 50 (15), pp.3585-95. ⟨10.1021/jm070262c⟩. ⟨inserm-00318976⟩

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