A. Billinton, A. O. Ige, J. P. Bolam, J. H. White, F. H. Marshall et al., Advances in the molecular understanding of GABAB receptors, Trends in Neurosciences, vol.24, issue.5, pp.277-282, 2001.
DOI : 10.1016/S0166-2236(00)01815-4

A. Couve, S. J. Moss, and M. N. Pangalos, GABAB Receptors: A New Paradigm in G Protein Signaling, Molecular and Cellular Neuroscience, vol.16, issue.4, pp.296-312, 2000.
DOI : 10.1006/mcne.2000.0908

K. Kaupmann, K. Huggel, J. Heid, P. J. Flor, S. Bischoff et al., Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors, Nature, vol.386, issue.6622, pp.239-246, 1997.
DOI : 10.1038/386239a0

J. Pin, T. Galvez, and L. Prezeau, Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors, Pharmacology & Therapeutics, vol.98, issue.3, pp.325-354, 2003.
DOI : 10.1016/S0163-7258(03)00038-X

J. Kniazeff, P. Saintot, C. Goudet, J. Liu, A. Charnet et al., Locking the Dimeric GABAB G-Protein-Coupled Receptor in Its Active State, Journal of Neuroscience, vol.24, issue.2, pp.370-377, 2004.
DOI : 10.1523/JNEUROSCI.3141-03.2004

URL : https://hal.archives-ouvertes.fr/hal-00319013

R. Kuner, G. Köhr, S. Grünewald, G. Eisenhardt, A. Bach et al., Role of Heteromer Formation in GABAB Receptor Function, Science, vol.283, issue.5398, pp.74-77, 1999.
DOI : 10.1126/science.283.5398.74

G. Y. Ng, J. Clark, N. Coulombe, N. Ethier, T. E. Hebert et al., Identification of a GABAB Receptor Subunit, gb2, Required for Functional GABAB Receptor Activity, Journal of Biological Chemistry, vol.274, issue.12, pp.7607-7610, 1999.
DOI : 10.1074/jbc.274.12.7607

B. Duthey, S. Caudron, J. Perroy, B. Bettler, L. Fagni et al., A Single Subunit (GB2) Is Required for G-protein Activation by the Heterodimeric GABAB Receptor, Journal of Biological Chemistry, vol.277, issue.5, pp.3236-3241, 2002.
DOI : 10.1074/jbc.M108900200

URL : https://hal.archives-ouvertes.fr/inserm-00318936

T. Galvez, B. Duthey, J. Kniazeff, J. Blahos, G. Rovelli et al., Allosteric interactions between GB1 andGB2 subunits are required for optimalGABAB receptor function, The EMBO Journal, vol.20, issue.9, pp.2152-2159, 2001.
DOI : 10.1093/emboj/20.9.2152

M. Havlickova, L. Prezeau, B. Duthey, B. Bettler, J. P. Pin et al., The Intracellular Loops of the GB2 Subunit Are Crucial for G-Protein Coupling of the Heteromeric gamma -Aminobutyrate B Receptor, Molecular Pharmacology, vol.62, issue.2, pp.343-350, 2002.
DOI : 10.1124/mol.62.2.343

S. C. Martin, S. J. Russek, and D. H. Farb, Molecular cellular Neurosci, pp.180-191, 1999.

A. R. Calver, A. D. Medhurst, M. J. Robbins, K. J. Charles, M. L. Evans et al., The expression of GABAB1 and GABAB2 receptor subunits in the cNS differs from that in peripheral tissues, Neuroscience, vol.100, issue.1, pp.155-170, 2000.
DOI : 10.1016/S0306-4522(00)00262-1

E. Vernon, G. Meyer, L. Pickard, K. Dev, E. Molnar et al., GABAB Receptors Couple Directly to the Transcription Factor ATF4, Molecular and Cellular Neuroscience, vol.17, issue.4, pp.637-645, 2001.
DOI : 10.1006/mcne.2000.0960

J. H. White, R. A. Mcillhinney, A. Wise, F. Ciruela, W. Y. Chan et al., The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx, Proceedings of the National Academy of Sciences, vol.97, issue.25, pp.13967-13972, 2000.
DOI : 10.1073/pnas.240452197

F. Gasparini, R. Kuhn, and J. P. And-pin, Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives, Current Opinion in Pharmacology, vol.2, issue.1, pp.43-49, 2002.
DOI : 10.1016/S1471-4892(01)00119-9

J. Hu and A. M. Spiegel, Naturally occurring mutations of the extracellular Ca2+-sensing receptor: implications for its structure and function, Trends in Endocrinology & Metabolism, vol.14, issue.6, pp.282-288, 2003.
DOI : 10.1016/S1043-2760(03)00104-8

A. Pagano, D. Ruegg, S. Litschig, N. Stoehr, C. Stierlin et al., The Non-competitive Antagonists 2-Methyl-6-(phenylethynyl)pyridine and 7-Hydroxyiminocyclopropan[b]chromen-1a-carboxylic Acid Ethyl Ester Interact with Overlapping Binding Pockets in the Transmembrane Region of Group I Metabotropic Glutamate Receptors, Journal of Biological Chemistry, vol.275, issue.43, pp.33750-33758, 2000.
DOI : 10.1074/jbc.M006230200

H. Schaffhauser, B. A. Rowe, S. Morales, L. E. Chavez-noriega, R. Yin et al., Pharmacological Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2, Molecular Pharmacology, vol.64, issue.4, pp.798-810, 2003.
DOI : 10.1124/mol.64.4.798

M. P. Johnson, M. Baez, G. E. Jagdmann, . Jr, T. C. Britton et al., -(2,2,2??? trifluoroethylsulfonyl)pyrid-3-ylmethylamine, Journal of Medicinal Chemistry, vol.46, issue.15, pp.3189-3192, 2003.
DOI : 10.1021/jm034015u

M. J. Marino, D. L. Williams, . Jr, J. A. O-'brien, O. Valenti et al., Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment, Proceedings of the National Academy of Sciences, vol.100, issue.23, pp.13668-13673, 2003.
DOI : 10.1073/pnas.1835724100

J. M. Mathiesen, N. Svendsen, H. Brauner-osborne, C. Thomsen, and M. T. Ramirez, Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP, British Journal of Pharmacology, vol.290, issue.6, pp.1026-1030, 2003.
DOI : 10.1038/sj.bjp.0705159

O. 'brien, J. A. Lemaire, W. Chen, T. B. Chang, R. S. Jacobson et al., A Family of Highly Selective Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5, Molecular Pharmacology, vol.64, issue.3, pp.731-740, 2003.
DOI : 10.1124/mol.64.3.731

P. Malherbe, N. Kratochwil, F. Knoflach, M. T. Zenner, J. N. Kew et al., Mutational Analysis and Molecular Modeling of the Allosteric Binding Site of a Novel, Selective, Noncompetitive Antagonist of the Metabotropic Glutamate 1 Receptor, Journal of Biological Chemistry, vol.278, issue.10, pp.8340-8347, 2003.
DOI : 10.1074/jbc.M211759200

P. Malherbe, N. Kratochwil, M. T. Zenner, J. Piussi, C. Diener et al., Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine, Molecular Pharmacology, vol.64, issue.4, pp.823-832, 2003.
DOI : 10.1124/mol.64.4.823

H. Lavreysen, C. Janssen, F. Bischoff, X. Langlois, J. E. Leysen et al., [3H]R214127: A Novel High-Affinity Radioligand for the mGlu1 Receptor Reveals a Common Binding Site Shared by Multiple Allosteric Antagonists, Molecular Pharmacology, vol.63, issue.5, pp.1082-1093, 2003.
DOI : 10.1124/mol.63.5.1082

S. Urwyler, M. F. Pozza, K. Lingenhoehl, J. Mosbacher, C. Lampert et al., N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and Structurally Related Compounds: Novel Allosteric Enhancers of ??-Aminobutyric AcidB Receptor Function, Journal of Pharmacology and Experimental Therapeutics, vol.307, issue.1, pp.322-330, 2001.
DOI : 10.1124/jpet.103.053074

M. Franek, A. Pagano, K. Kaupmann, B. Bettler, J. P. Pin et al., The heteromeric GABA-B receptor recognizes G-protein ?? subunit C-termini, Neuropharmacology, vol.38, issue.11, pp.1657-1666, 1999.
DOI : 10.1016/S0028-3908(99)00135-5

I. Brabet, M. Parmentier, J. Bockaert, F. Acher, and J. And-pin, Comparative effect of l-CCG-I, DCG-IV and ??-carboxy-l-glutamate on all cloned metabotropic glutamate receptor subtypes, Neuropharmacology, vol.37, issue.8, pp.1043-1051, 1998.
DOI : 10.1016/S0028-3908(98)00091-4

C. Goudet, F. Gaven, J. Kniazeff, C. Vol, J. Liu et al., Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors, Proceedings of the National Academy of Sciences, vol.101, issue.1, pp.378-383, 2004.
DOI : 10.1073/pnas.0304699101

URL : https://hal.archives-ouvertes.fr/inserm-00319003

A. Couve, A. K. Filippov, C. N. Connolly, B. Bettler, D. A. Brown et al., Intracellular Retention of Recombinant GABABReceptors, Journal of Biological Chemistry, vol.273, issue.41, pp.26361-26367, 1998.
DOI : 10.1074/jbc.273.41.26361

S. Grunewald, B. J. Schupp, S. R. Ikeda, R. Kuner, F. Steigerwald et al., Importance of the gamma -Aminobutyric AcidB Receptor C-Termini for G-Protein Coupling, Molecular Pharmacology, vol.61, issue.5, pp.1070-1080, 2002.
DOI : 10.1124/mol.61.5.1070

K. Palczewski, T. Kumasaka, T. Hori, C. A. Behnke, H. Motoshima et al., Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor, Science, vol.289, issue.5480, pp.739-745, 2000.
DOI : 10.1126/science.289.5480.739

M. Chabre, R. Cone, and H. Saibil, Biophysics (communication arising): Is rhodopsin dimeric in native retinal rods?, Nature, vol.426, issue.6962, pp.30-31, 2003.
DOI : 10.1038/426030b

M. L. Parmentier, L. Prezeau, J. Bockaert, and J. P. And-pin, A model for the functioning of family 3 GPCRs, Trends in Pharmacological Sciences, vol.23, issue.6, pp.268-274, 2002.
DOI : 10.1016/S0165-6147(02)02016-3

L. Joubert, S. Claeysen, M. Sebben, A. Bessis, R. D. Clark et al., A 5-HT4 Receptor Transmembrane Network Implicated in the Activity of Inverse Agonists but Not Agonists, Journal of Biological Chemistry, vol.277, issue.28, pp.25502-25511, 2002.
DOI : 10.1074/jbc.M202539200

T. Okada, O. Enrnst, K. Palczewski, and K. P. Hofmann, Activation of rhodopsin: new insights from structural and biochemical studies, Trends in Biochemical Sciences, vol.26, issue.5, pp.318-324, 2001.
DOI : 10.1016/S0968-0004(01)01799-6