S. Terrillon and M. Bouvier, Roles of G-protein-coupled receptor dimerization, EMBO reports, vol.5, issue.1, pp.30-34, 2004.
DOI : 10.1038/sj.embor.7400052

C. Romano, W. Yang, O. Malley, and K. L. , Metabotropic Glutamate Receptor 5 Is a Disulfide-linked Dimer, Journal of Biological Chemistry, vol.271, issue.45, pp.28612-28616, 1996.
DOI : 10.1074/jbc.271.45.28612

M. Margeta-mitrovic, Y. N. Jan, J. , and L. Y. , A Trafficking Checkpoint Controls GABAB Receptor Heterodimerization, Neuron, vol.27, issue.1, pp.97-106, 2000.
DOI : 10.1016/S0896-6273(00)00012-X

G. Nelson, J. Chandrashekar, M. A. Hoon, L. Feng, G. Zhao et al., An amino-acid taste receptor, Nature, vol.756, issue.6877, pp.199-202, 2002.
DOI : 10.1038/nature726

G. Nelson, M. A. Hoon, J. Chandrashekar, Y. Zhang, N. J. Ryba et al., Mammalian Sweet Taste Receptors, Cell, vol.106, issue.3, pp.381-390, 2001.
DOI : 10.1016/S0092-8674(01)00451-2
URL : http://doi.org/10.1016/s0092-8674(01)00451-2

H. Xu, L. Staszewski, H. Tang, E. Adler, M. Zoller et al., Different functional roles of T1R subunits in the heteromeric taste receptors, Proceedings of the National Academy of Sciences, vol.101, issue.39, pp.14258-14263, 2004.
DOI : 10.1073/pnas.0404384101

M. Tateyama, H. Abe, H. Nakata, O. Saito, and Y. Kubo, Ligand-induced rearrangement of the dimeric metabotropic glutamate receptor 1??, Nature Structural & Molecular Biology, vol.7, issue.7, pp.637-642, 2004.
DOI : 10.1016/S1044-7431(03)00052-6

L. T. May, C. , and A. , Allosteric modulators of G-protein-coupled receptors, Current Opinion in Pharmacology, vol.3, issue.5, pp.551-556, 2003.
DOI : 10.1016/S1471-4892(03)00107-3

C. Goudet, V. Binet, L. Prézeau, and J. P. And-pin, Drug discovery today 1, pp.125-133, 2004.

J. N. Kew, Positive and negative allosteric modulation of metabotropic glutamate receptors: emerging therapeutic potential, Pharmacology & Therapeutics, vol.104, issue.3, pp.233-244, 2004.
DOI : 10.1016/j.pharmthera.2004.08.010

A. A. Jensen and T. A. Spalding, Allosteric modulation of G-protein coupled receptors, European Journal of Pharmaceutical Sciences, vol.21, issue.4, pp.407-420, 2004.
DOI : 10.1016/j.ejps.2003.11.007

D. M. Shoback, J. P. Bilezikian, S. A. Turner, L. C. Mccary, M. D. Guo et al., The Calcimimetic Cinacalcet Normalizes Serum Calcium in Subjects with Primary Hyperparathyroidism, The Journal of Clinical Endocrinology & Metabolism, vol.88, issue.12, pp.5644-5649, 2003.
DOI : 10.1210/jc.2002-021597

C. Petrel, A. Kessler, P. Dauban, R. H. Dodd, D. Rognan et al., Positive and Negative Allosteric Modulators of the Ca2+-sensing Receptor Interact within Overlapping but Not Identical Binding Sites in the Transmembrane Domain, Journal of Biological Chemistry, vol.279, issue.18, pp.18990-18997, 2004.
DOI : 10.1074/jbc.M400724200
URL : https://hal.archives-ouvertes.fr/hal-00169809

H. J. Schaffhauser, B. A. Rowe, S. Morales, L. E. Chavez-noriega, R. Yin et al., Pharmacological Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2, Molecular Pharmacology, vol.64, issue.4, pp.798-810, 2003.
DOI : 10.1124/mol.64.4.798

V. Binet, C. Brajon, L. Le-corre, F. Acher, J. P. Pin et al., The Heptahelical Domain of GABAB2 Is Activated Directly by CGP7930, a Positive Allosteric Modulator of the GABAB Receptor, Journal of Biological Chemistry, vol.279, issue.28, pp.29085-29091, 2004.
DOI : 10.1074/jbc.M400930200
URL : https://hal.archives-ouvertes.fr/inserm-00318926

C. Goudet, F. Gaven, J. Kniazeff, C. Vol, J. Liu et al., Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors, Proceedings of the National Academy of Sciences, vol.101, issue.1, pp.378-383, 2004.
DOI : 10.1073/pnas.0304699101
URL : https://hal.archives-ouvertes.fr/inserm-00319003

J. Kniazeff, A. S. Bessis, D. Maurel, H. Ansanay, L. Prezeau et al., Closed state of both binding domains of homodimeric mGlu receptors is required for full activity, Nature Structural & Molecular Biology, vol.18, issue.8, pp.706-713, 2004.
DOI : 10.1016/S0028-3908(98)00091-4
URL : https://hal.archives-ouvertes.fr/hal-00318999

V. Hlavackova, C. Goudet, J. Kniazeff, A. Zikova, D. Maurel et al., Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR, The EMBO Journal, vol.275, issue.3, pp.499-509, 2005.
DOI : 10.1016/S0896-6273(00)80708-4
URL : https://hal.archives-ouvertes.fr/inserm-00318934

F. Ango, S. Albani-torregrossa, C. Joly, D. Robbe, J. Michel et al., A simple method to transfer plasmid DNA into neuronal primary cultures: functional expression of the mGlu5 receptor in cerebellar granule cells, Neuropharmacology, vol.38, issue.6, pp.793-803, 1999.
DOI : 10.1016/S0028-3908(99)00005-2

L. Fourgeaud, A. Bessis, F. Rossignol, J. Pin, J. Olivo et al., The Metabotropic Glutamate Receptor mGluR5 Is Endocytosed by a Clathrin-independent Pathway, Journal of Biological Chemistry, vol.278, issue.14, pp.12222-12230, 2003.
DOI : 10.1074/jbc.M205663200

M. Havlickova, J. Blahos, I. Brabet, J. Liu, B. Hruskova et al., The Second Intracellular Loop of Metabotropic Glutamate Receptors Recognizes C Termini of G-protein ??-Subunits, Journal of Biological Chemistry, vol.278, issue.37, pp.35063-35070, 2003.
DOI : 10.1074/jbc.M306555200

I. Brabet, M. Parmentier, C. De-colle, J. Bockaert, F. Acher et al., Comparative effect of l-CCG-I, DCG-IV and ??-carboxy-l-glutamate on all cloned metabotropic glutamate receptor subtypes, Neuropharmacology, vol.37, issue.8, pp.1043-1051, 1998.
DOI : 10.1016/S0028-3908(98)00091-4

D. Maurel, J. Kniazeff, G. Mathis, E. Trinquet, J. P. Pin et al., Cell surface detection of membrane protein interaction with homogeneous time-resolved fluorescence resonance energy transfer technology, Analytical Biochemistry, vol.329, issue.2, pp.253-262, 2004.
DOI : 10.1016/j.ab.2004.02.013
URL : https://hal.archives-ouvertes.fr/hal-00318979

O. 'brien, J. A. Lemaire, W. Chen, T. Chang, R. S. Jacobson et al., A Family of Highly Selective Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5, Molecular Pharmacology, vol.64, issue.3, pp.731-740, 2003.
DOI : 10.1124/mol.64.3.731

A. Francesconi and R. M. Duvoisin, Role of the Second and Third Intracellular Loops of Metabotropic Glutamate Receptors in Mediating Dual Signal Transduction Activation, Journal of Biological Chemistry, vol.273, issue.10, pp.5615-5624, 1998.
DOI : 10.1074/jbc.273.10.5615

M. J. Robbins, F. Ciruela, A. Rhodes, and R. A. Mcilhinney, Characterization of the Dimerization of Metabotropic Glutamate Receptors Using an N-Terminal Truncation of mGluR1??, Journal of Neurochemistry, vol.21, issue.6, pp.2539-2547, 1999.
DOI : 10.1046/j.1471-4159.1999.0722539.x

J. L. Baneres and J. Parello, Structure-based Analysis of GPCR Function: Evidence for a Novel Pentameric Assembly between the Dimeric Leukotriene B4 Receptor BLT1 and the G-protein, Journal of Molecular Biology, vol.329, issue.4, pp.815-829, 2003.
DOI : 10.1016/S0022-2836(03)00439-X

H. E. Hamm, How activated receptors couple to G proteins, Proceedings of the National Academy of Sciences, vol.98, issue.9, pp.4819-4821, 2001.
DOI : 10.1073/pnas.011099798
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC33117

Y. Liang, D. Fotiadis, S. Filipek, D. A. Saperstein, K. Palczewski et al., Organization of the G Protein-coupled Receptors Rhodopsin and Opsin in Native Membranes, Journal of Biological Chemistry, vol.278, issue.24, pp.21655-21662, 2003.
DOI : 10.1074/jbc.M302536200