F. C. Acher and H. O. Bertrand, Amino acid recognition by Venus flytrap domains is encoded in an 8-residue motif, Biopolymers, vol.35, issue.2-3, pp.357-366, 2005.
DOI : 10.1002/bip.20229

M. Afshar, R. E. Hubbard, and J. Demaille, Towards structural models of molecular recognition in olfactory receptors, Biochimie, vol.80, issue.2, pp.129-135, 1998.
DOI : 10.1016/S0300-9084(98)80019-9

I. Brabet, M. Parmentier, J. Bockaert, F. Acher, and J. Pin, Effect of g-carboxy-L-glutamate and DCG-IV on metabotropic glutamate receptor types 1, 2 and 4, Neuropharmacology, vol.37, 1998.

V. Bruno, G. Battaglia, A. Copani, M. Onofrio, D. Iorio et al., Metabotropic Glutamate Receptor Subtypes as Targets for Neuroprotective Drugs, Journal of Cerebral Blood Flow & Metabolism, vol.10, 2001.
DOI : 10.1097/00004647-200109000-00001

A. D. Conigrave, S. J. Quinn, and E. M. Brown, L-Amino acid sensing by the extracellular Ca2+-sensing receptor, Proceedings of the National Academy of Sciences, vol.97, issue.9, pp.4814-4819, 2000.
DOI : 10.1073/pnas.97.9.4814

N. C. Danbolt, Glutamate uptake, Progress in Neurobiology, vol.65, issue.1, pp.1-105, 2001.
DOI : 10.1016/S0301-0082(00)00067-8

J. A. Davies, S. J. Annels, B. G. Dickie, Y. Ellis, and N. J. Knott, A comparison between the stimulated and paroxysmal release of endogenous amino acids from rat cerebellar, striatal and hippocampal slices: a manifestation of spreading depression?, Journal of the Neurological Sciences, vol.131, issue.1, pp.8-14, 1995.
DOI : 10.1016/0022-510X(95)00100-G

J. Gomeza, S. Mary, I. Brabet, M. Parmentier, S. Restituito et al., Coupling of metabotropic glutamate receptors 2 and 4 to G a15 , G a16 and chimeric G aq/i proteins: characterization of new anatgonists, Mol. Pharmacol, vol.50, pp.923-930, 1996.

C. Goudet, F. Gaven, J. Kniazeff, C. Vol, J. Liu et al., Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors, Proc. Natl. Acad. Sci. U.S.A. 101, pp.378-383, 2004.
DOI : 10.1073/pnas.0304699101

URL : https://hal.archives-ouvertes.fr/inserm-00319003

C. Joly, J. Gomeza, I. Brabet, K. Curry, J. Bockaert et al., Molecular , functional and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1, J. Neurosci, vol.15, pp.3970-3981, 1995.

A. Kingston, J. Lowndes, N. Evans, B. Clark, R. Tomlinson et al., Sulphur-containing amino acids are agonists for group 1 metabotropic receptors expressed in clonal RGT cell lines, Neuropharmacology, vol.37, issue.3, pp.277-287, 1998.
DOI : 10.1016/S0028-3908(98)00018-5

N. Kunishima, Y. Shimada, Y. Tsuji, T. Sato, M. Yamamoto et al., Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor, Nature, vol.407, pp.971-977, 2000.

J. W. Lazarewicz, A. Ziembowicz, E. Matyja, A. Stafiej, and E. Zieminska, Ca Release in the Rabbit Hippocampus Is Mediated by Both NMDA and Group I Metabotropic Glutamate Receptors: In Vivo Microdialysis Study, Neurochemical Research, vol.28, issue.2, pp.259-269, 2003.
DOI : 10.1023/A:1022329317218

X. Li, L. Staszewski, H. Xu, K. Durick, M. Zoller et al., Human receptors for sweet and umami taste, Proc. Natl. Acad. Sci. U.S.A. 99, pp.4692-4696, 2002.
DOI : 10.1073/pnas.072090199

U. Magnusson, B. Salopek-sondi, L. A. Luck, and S. L. Mowbray, X-ray Structures of the Leucine-binding Protein Illustrate Conformational Changes and the Basis of Ligand Specificity, Journal of Biological Chemistry, vol.279, issue.10, 2004.
DOI : 10.1074/jbc.M311890200

G. J. Mcbean and J. Flynn, Molecular mechanisms of cystine transport, Biochemical Society Transactions, vol.29, issue.6, pp.717-722, 2001.
DOI : 10.1042/bst0290717

G. J. Mcbean, Cerebral cystine uptake: a tale of two transporters, Trends in Pharmacological Sciences, vol.23, issue.7, pp.299-302, 2002.
DOI : 10.1016/S0165-6147(02)02060-6

R. I. Melendez, J. Vuthiganon, and P. W. Kalivas, Regulation of Extracellular Glutamate in the Prefrontal Cortex: Focus on the Cystine Glutamate Exchanger and Group I Metabotropic Glutamate Receptors, Journal of Pharmacology and Experimental Therapeutics, vol.314, issue.1, pp.139-147, 2005.
DOI : 10.1124/jpet.104.081521

S. Molchanova, P. Koobi, S. S. Oja, and P. Saransaari, Interstitial Concentrations of Amino Acids in the Rat Striatum During Global Forebrain Ischemia and Potassium-Evoked Spreading Depression, Neurochemical Research, vol.29, issue.8, pp.1519-1527, 2004.
DOI : 10.1023/B:NERE.0000029564.98905.5c

H. C. Mun, A. H. Franks, E. L. Culverston, K. Krapcho, E. F. Nemeth et al., The Venus Fly Trap domain of the extracellular Ca2þ-sensing receptor is required for L-amino-acid sensing, J. Biol. Chem, vol.279, 2004.

H. C. Mun, E. L. Culverston, A. H. Franks, C. A. Collyer, R. J. Clifton-bligh et al., A Double Mutation in the Extracellular Ca2+-sensing Receptor's Venus Flytrap Domain That Selectively Disables L-Amino Acid Sensing, Journal of Biological Chemistry, vol.280, issue.32, pp.29067-29072, 2005.
DOI : 10.1074/jbc.M500002200

G. Nelson, M. A. Hoon, J. Chandrashekar, Y. Zhang, N. J. Ryba et al., Mammalian Sweet Taste Receptors, Cell, vol.106, issue.3, pp.381-390, 2001.
DOI : 10.1016/S0092-8674(01)00451-2

G. Nelson, J. Chandrashekar, M. A. Hoon, L. Feng, G. Zhao et al., An amino-acid taste receptor, Nature, vol.756, issue.6877, 2002.
DOI : 10.1038/nature726

O. 'hara, P. J. Sheppard, P. O. Thogersen, H. Venezia, D. Haldeman et al., The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins, Neuron, vol.11, 1993.

E. Palmer, D. T. Monaghan, and C. W. Cotman, Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor, European Journal of Pharmacology, vol.166, issue.3, pp.585-587, 1989.
DOI : 10.1016/0014-2999(89)90383-X

M. L. Parmentier, C. Joly, S. Restituito, J. Bockaert, Y. Grau et al., The G-protein coupling profile of metabotropic glutamate receptors, as determined with exogenous G-proteins, is independent of their ligand recognition domain, Mol. Pharmacol, vol.53, pp.778-786, 1998.

M. L. Parmentier, T. Galvez, F. Acher, B. Peyre, R. Pellicciari et al., Conservation of the ligand recognition site of metabotropic glutamate receptors during evolution, Neuropharmacology, vol.39, issue.7, 2000.
DOI : 10.1016/S0028-3908(99)00204-X

J. Pin and F. Acher, The Metabotropic Glutamate Receptors: Structure, Activation Mechanism and Pharmacology, Current Drug Target -CNS & Neurological Disorders, vol.1, issue.3, pp.297-317, 2002.
DOI : 10.2174/1568007023339328

J. Pin, T. Galvez, and L. Prezeau, Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors, Pharmacology & Therapeutics, vol.98, issue.3, pp.325-354, 2003.
DOI : 10.1016/S0163-7258(03)00038-X

D. V. Pow, Visualising the activity of the cystine-glutamate antiporter in glial cells using antibodies to aminoadipic acid, a selectively transported substrate, Glia, vol.14, issue.1, pp.27-38, 2001.
DOI : 10.1002/glia.1037

A. I. Qureshi, Z. Ali, M. F. Suri, A. Shuaib, G. Baker et al., Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: An in vivo microdialysis study, Critical Care Medicine, vol.31, issue.5, p.31, 2003.
DOI : 10.1097/01.CCM.0000063047.63862.99

Y. Sagara and D. Schubert, The activation of metabotropic glutamate receptors protects nerve cells from oxidative stress, J. Neurosci, vol.18, pp.6662-6671, 1998.

H. Sato, M. Tamba, S. Okuno, K. Sato, K. Keino-masu et al., Distribution of cystine/glutamate exchange transporter, system x(c)-, in the mouse brain, J. Neurosci, vol.22, pp.8028-8033, 2002.

D. D. Schoepp, D. E. Jane, and J. A. Monn, Pharmacological agents acting at subtypes of metabotropic glutamate receptors, Neuropharmacology, vol.38, issue.10, 1999.
DOI : 10.1016/S0028-3908(99)00092-1

Q. Shi, J. E. Savage, S. J. Hufeisen, L. Rauser, E. Grajkowska et al., L-Homocysteine Sulfinic Acid and Other Acidic Homocysteine Derivatives Are Potent and Selective Metabotropic Glutamate Receptor Agonists, Journal of Pharmacology and Experimental Therapeutics, vol.305, issue.1, pp.131-142, 2003.
DOI : 10.1124/jpet.102.047092

N. Shimada, R. Graf, G. Rosner, and W. D. Heiss, Ischemia-Induced Accumulation of Extracellular Amino Acids in Cerebral Cortex, White Matter, and Cerebrospinal Fluid, Journal of Neurochemistry, vol.21, issue.1, pp.66-71, 1993.
DOI : 10.1016/0006-8993(82)90905-2

D. J. Speca, D. M. Lin, P. W. Sorensen, E. Y. Isacoff, J. Ngai et al., Functional Identification of a Goldfish Odorant Receptor, Neuron, vol.23, issue.3, pp.487-498, 1999.
DOI : 10.1016/S0896-6273(00)80802-8

P. Wellendorph, K. B. Hansen, A. Balsgaard, J. R. Greenwood, J. Egebjerg et al., Deorphanization of GPRC6A: A Promiscuous L-??-Amino Acid Receptor with Preference for Basic Amino Acids, Molecular Pharmacology, vol.67, issue.3, pp.589-597, 2005.
DOI : 10.1124/mol.104.007559

J. Wichmann, K. Bleicher, E. Vieira, T. Woltering, F. Knoflach et al., Alkyl diphenylacetyl, 9H-xanthene- and 9H-thioxanthene-carbonyl carbamates as positive allosteric modulators of mGlu1 receptors, Il Farmaco, vol.57, issue.12, pp.989-992, 2002.
DOI : 10.1016/S0014-827X(02)01283-1

Z. X. Xi, H. Shen, D. A. Baker, and P. W. Kalivas, Inhibition of non-vesicular glutamate release by group III metabotropic glutamate receptors in the nucleus accumbens, Journal of Neurochemistry, vol.19, issue.5, 2003.
DOI : 10.1046/j.1471-4159.2003.02093.x

H. Xu, L. Staszewski, H. Tang, E. Adler, M. Zoller et al., Different functional roles of T1R subunits in the heteromeric taste receptors, Proceedings of the National Academy of Sciences, vol.101, issue.39, 2004.
DOI : 10.1073/pnas.0404384101

N. Zerangue and M. P. Kavanaugh, Interaction of L-cysteine with a human excitatory amino acid transporter., The Journal of Physiology, vol.493, issue.2, pp.419-423, 1996.
DOI : 10.1113/jphysiol.1996.sp021393

Z. Zhang, Y. Jiang, S. J. Quinn, K. Krapcho, E. F. Nemeth et al., L-Phenylalanine and NPS R-467 Synergistically Potentiate the Function of the Extracellular Calcium-sensing Receptor through Distinct Sites, Journal of Biological Chemistry, vol.277, issue.37, pp.33736-33741, 2002.
DOI : 10.1074/jbc.M200978200

Z. Zhang, W. Qiu, S. J. Quinn, A. D. Conigrave, E. M. Brown et al., Three Adjacent Serines in the Extracellular Domains of the CaR Are Required for L-Amino Acid-mediated Potentiation of Receptor Function, Journal of Biological Chemistry, vol.277, issue.37, pp.33727-33735, 2002.
DOI : 10.1074/jbc.M200976200