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Journal articles
Dendritic cells and innate defense against tumor cells.
Evelyn Ullrich
1
Cédric Ménard
1
Caroline Flament
1
Magali Terme
1
Grégoire Mignot
1
Mathieu Bonmort
1
Joël Plumas
2
Laurence Chaperot
3, 4
Nathalie Chaput
1, 5
Laurence Zitvogel
1, 5
2
INSERM U823, équipe 9 (Immunobiologie et Immunothérapie des Cancers)
INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble, Laboratoire recherche et développement
Grégoire Mignot 1
Author
Mathieu Bonmort 1
Author
Joël Plumas 2
Author
Laurence Chaperot 3, 4
Author
Nathalie Chaput 1, 5
Author
Laurence Zitvogel 1, 5
Author
1
Role des Cellules Dendritiques Dans la Regulation des Effecteurs de l'Immunite Antitumorale (Institut Gustave Roussy 39, Rue Camille Desmoulins 94805 VILLEJUIF CEDEX - France)
- UP11 - Université Paris-Sud - Paris 11 (Bâtiment 300 - 91405 Orsay cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U805 (101, rue de Tolbiac, 75013 Paris - France)
2
INSERM U823, équipe 9 (Immunobiologie et Immunothérapie des Cancers) (France)
- INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble (Institut Albert Bonniot, BP170, 38042 Grenoble Cedex 9 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U823 (101, rue de Tolbiac, 75013 Paris - France)
- EFS (France)
- CHU Grenoble (France)
- UJF - Université Joseph Fourier - Grenoble 1 (BP 53 - 38041 Grenoble Cedex 9 - France)
- Laboratoire recherche et développement (38701 La Tronche - France)
- EFS (France)
4
INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble (Institut Albert Bonniot, BP170, 38042 Grenoble Cedex 9 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U823 (101, rue de Tolbiac, 75013 Paris - France)
- EFS (France)
- CHU Grenoble (France)
- UJF - Université Joseph Fourier - Grenoble 1 (BP 53 - 38041 Grenoble Cedex 9 - France)
5
CIC 1428 , CBT 507 - Centre d'Investigation Clinique en Biotherapie des cancers (Gustave Roussy. 114, rue Édouard-Vaillant 94805 Villejuif Cedex -France - France)
- IGR - Institut Gustave Roussy : CBT507 (114, rue Édouard-Vaillant 94805 Villejuif Cedex -France - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : CIC1428 (101, rue de Tolbiac, 75013 Paris - France)
Abstract : Tumor growth results from a delicate balance between intrinsic dysregulation of oncogenes, tumor suppressor and stability genes counteracted by extrinsic defenses composed of immune cells shaping tumor immunogenicity. Although immune subversion might be the ultimate outcome of this process, a complex network of cellular interactions take place eventually leading to tumor specific cognate immune responses. The links between innate and cognate antitumor immunity eliciting protective T cell responses are instigated by cytokines, chemokines and damage associated molecular patterns. The intricate differentiation pathway whereby dendritic cells could undergo an efficient maturation program in the tumor microenvironment appears crucial. We will discuss the role of innate effectors and cancer therapies in the process of defense against tumor cells.
Document type :
Journal articles
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Complete list of metadatas
https://www.hal.inserm.fr/inserm-00318515
Contributor : Laurence Chaperot <>
Submitted on : Thursday, September 4, 2008 - 10:38:24 AM
Last modification on : Friday, November 6, 2020 - 4:13:15 AM
Contributor : Laurence Chaperot <>
Submitted on : Thursday, September 4, 2008 - 10:38:24 AM
Last modification on : Friday, November 6, 2020 - 4:13:15 AM
Identifiers
- HAL Id : inserm-00318515, version 1
- DOI : 10.1016/j.cytogfr.2007.10.009
- PUBMED : 18155952
Citation
Evelyn Ullrich, Cédric Ménard, Caroline Flament, Magali Terme, Grégoire Mignot, et al.. Dendritic cells and innate defense against tumor cells.. Cytokine & Growth Factor Reviews, 2008, 19 (1), pp.79-92. ⟨10.1016/j.cytogfr.2007.10.009⟩. ⟨inserm-00318515⟩
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