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Journal articles
Lipid-bloated subretinal microglial cells are at the origin of drusen appearance in CX3CR1-deficient mice.
Abstract : Drusen, the white yellowish deposits that can be seen in funduscopy, are a hallmark of age-related macular degeneration. Histologically, drusen are believed to be dome-shaped or more confluent lipid accumulations between the retinal pigment epithelium and the choriocapillaries. Recent advances in mouse funduscopy have revealed the presence of drusen-like structures in chemokine knockout animals in the absence of sizeable dome-shaped material below the retinal pigment epithelium. We show that aged CX3CR1-/- mice present with drusen-like appearance in funduscopy that is associated with a progressive age-related microglial cell accumulation in the subretinal space. We demonstrate that the anatomical equivalent of the drusen-like appearance in these mice are lipid-bloated subretinal microglial cells rather than subretinal pigment epithelium deposits [Combadi? C, et al: J Clin Invest 2007;117:2920-2928].
Cited literature [19 references]
https://www.hal.inserm.fr/inserm-00315944
Contributor : Florian Sennlaub <>
Submitted on : Friday, November 13, 2009 - 11:26:51 AM
Last modification on : Wednesday, August 19, 2020 - 11:16:29 AM
Long-term archiving on: : Thursday, June 3, 2010 - 7:19:56 PM
Contributor : Florian Sennlaub <>
Submitted on : Friday, November 13, 2009 - 11:26:51 AM
Last modification on : Wednesday, August 19, 2020 - 11:16:29 AM
Long-term archiving on: : Thursday, June 3, 2010 - 7:19:56 PM
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