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Ghrelin receptor gene polymorphisms and body size in children and adults.: GHSR polymorphisms and body size

Abstract : Background: The GH secretagogue receptor type 1a gene (GHSR) encodes the cognate receptor of ghrelin, a gut hormone that regulates food intake and pituitary GH secretion. Previous studies in U.S. families and a German population suggested GHSR to be a candidate quantitative locus for association with human obesity and growth. Aim: The aim of the study was to test common genetic variation in GHSR for association with body size in children and adults. Methods: Sequencing was performed to systematically identify novel single nucleotide polymorphisms (SNPs) in GHSR. A set of three haplotype-tagging SNPs that captured all the genetic variation in GHSR was identified. These three haplotype-tagging SNPs were then genotyped in three large population-based U.K. cohort studies (two adult and one childhood cohort) comprising 5807 adults and 843 children. Results: No significant genotype or haplotype associations were found with adult or childhood height, weight, or body mass index. Conclusion: Common variation in GHSR is not associated with body size in U.K. adults or children.
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https://www.hal.inserm.fr/inserm-00311659
Contributor : Blandine de Lauzon-Guillain <>
Submitted on : Wednesday, August 20, 2008 - 9:04:21 AM
Last modification on : Wednesday, September 16, 2020 - 5:04:11 PM
Long-term archiving on: : Thursday, June 3, 2010 - 6:34:45 PM

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Edwin Garcia, Barbara Heude, Clive Petry, Maria Gueorguiev, Zaki Hassan-Smith, et al.. Ghrelin receptor gene polymorphisms and body size in children and adults.: GHSR polymorphisms and body size. Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2008, 93 (10), pp.4158-61. ⟨10.1210/jc.2008-0366⟩. ⟨inserm-00311659⟩

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