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The human spleen is a major reservoir for long-lived vaccinia virus-specific memory B cells.: Long-lived B cell memory in the spleen.

Abstract : The fact that you can vaccinate a child at 5 years of age and find lymphoid B cells and antibodies specific for this vaccination 70 years later remains an immunologic enigma. It has never been determined how these long-lived memory B cells are maintained and whether they are protected by storage in a special niche. We report that, whereas blood and spleen compartments present similar frequencies of IgG(+) cells, antismallpox memory B cells are specifically enriched in the spleen where they account for 0.24% of all IgG(+) cells (ie, 10-20 million cells) more than 30 years after vaccination. They represent, in contrast, only 0.07% of circulating IgG(+) B cells in blood (ie, 50-100,000 cells). An analysis of patients either splenectomized or rituximab-treated confirmed that the spleen is a major reservoir for long-lived memory B cells. No significant correlation was observed between the abundance of these cells in blood and serum titers of antivaccinia virus antibodies in this study, including in the contrasted cases of B cell-depleting treatments. Altogether, these data provide evidence that in humans, the two arms of B-cell memory--long-lived memory B cells and plasma cells--have specific anatomic distributions--spleen and bone marrow--and homeostatic regulation.
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https://www.hal.inserm.fr/inserm-00311504
Contributor : Maria Mamani-Matsuda <>
Submitted on : Monday, August 18, 2008 - 3:50:20 PM
Last modification on : Wednesday, October 14, 2020 - 3:47:54 AM
Long-term archiving on: : Thursday, June 3, 2010 - 6:30:38 PM

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Maria Mamani-Matsuda, Antonio Cosma, Sandra Weller, Ahmad Faili, Caroline Staib, et al.. The human spleen is a major reservoir for long-lived vaccinia virus-specific memory B cells.: Long-lived B cell memory in the spleen.. Blood, American Society of Hematology, 2008, 111 (9), pp.4653-9. ⟨10.1182/blood-2007-11-123844⟩. ⟨inserm-00311504⟩

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