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Journal Articles Journal of the Acoustical Society of America Year : 2008

Using a toroid transducer for thermal ablation by high-intensity-focused ultrasound increases the coagulated volume.

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Abstract

Here, we report that a new design of High Intensity Focused Ultrasound transducer can significantly enlarge the coagulated volume over short periods of time, and that treatment in the liver can be guided in real-time using an integrated ultrasound imaging probe. Eight ultrasound emitters, divided into 256 elements, were created by sectioning a single toroid piezocomposite transducer. The focal zone was conical in shape and located 70 mm from the transducer; enabling the treatment of deep-seated tumors. A single thermal lesion was created when the eight emitters performed alternative and consecutive 5 s ultrasound exposures. This paper presents in vivo evidence that the coagulated volume obtained from a 40 s total exposure in the liver was 7.0+/-2.5 cm(3) (min 1.5 - max 20.0 cm(3)). All lesions were visible with high contrast on sonograms. The correlation between the diameter of lesions observed on sonograms and during gross examination was 92%. This method also allowed the user to easily enlarge the coagulated volume by juxtaposing single lesions. This approach may have a role in treating unresectable colorectal liver metastases and may also be used in conjunction with resection to extend its limits.
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Dates and versions

inserm-00294599 , version 1 (09-07-2008)

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David Melodelima, William Apoutou N'Djin, Hubert Parmentier, Michel Rivoire, Jean-Yves Chapelon. Using a toroid transducer for thermal ablation by high-intensity-focused ultrasound increases the coagulated volume.. Journal of the Acoustical Society of America, 2008, 123 (5), pp.2995. ⟨10.1121/1.2932545⟩. ⟨inserm-00294599⟩
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