Cutting edge: selective expression of inhibitory or activating killer cell Ig-like receptors in circulating CD4+ T lymphocytes. - Archive ouverte HAL Access content directly
Journal Articles Journal of Immunology Year : 2008

Cutting edge: selective expression of inhibitory or activating killer cell Ig-like receptors in circulating CD4+ T lymphocytes.

(1) , (1) , (1)
1

Abstract

Apart from NK cells, TCRgammadelta and CD8+ T cells, killer cell Ig-like receptor (KIR) expression was described on a minor subset of CD4+ T cells. However, their functions remain to be elucidated in this latter lymphocyte population. We demonstrated that KIR2DL2/L3 (CD158b) and KIR2DS2 (CD158j) transcripts were synthesized by sorted CD4+CD158b/j+ T cells obtained from healthy individuals. In contrast, we observed that only the inhibitory or activating receptor was expressed at the cell surface according to the donor tested. In CD158b-expressing cells, KIR triggering leads to an inhibition of the CD3-induced cell proliferation and Erk activation, and the receptor exhibits an activation-dependent tyrosine phosphorylation and association with the Src homology 2-containing phosphatase 1. In CD158j-positive cells, KIR-engagement results in an enhanced CD3-mediated cell growth and Erk phosphorylation. Our results suggested that, in contrast to NK cells, the functions of KIR in CD4+ T lymphocytes might derive from a selective expression of their activating or inhibiting forms.
Fichier principal
Vignette du fichier
Remtoula_et_al-merged.pdf (256.13 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-00293824 , version 1 (23-03-2009)

Identifiers

  • HAL Id : inserm-00293824 , version 1
  • PUBMED : 18292496

Cite

Natacha Remtoula, Armand Bensussan, Anne Marie-Cardine. Cutting edge: selective expression of inhibitory or activating killer cell Ig-like receptors in circulating CD4+ T lymphocytes.. Journal of Immunology, 2008, 180 (5), pp.2767-71. ⟨inserm-00293824⟩

Collections

INSERM IMRB UPEC
118 View
325 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More