J. Ross, mRNA stability in mammalian cells, Microbiol. Rev, vol.59, pp.423-450, 1995.

P. Mitchell and D. Tollervey, mRNA stability in eukaryotes, Current Opinion in Genetics & Development, vol.10, issue.2, pp.193-198, 2000.
DOI : 10.1016/S0959-437X(00)00063-0

P. Mitchell and D. Tollervey, mRNA turnover, Current Opinion in Cell Biology, vol.13, issue.3, pp.320-325, 2001.
DOI : 10.1016/S0955-0674(00)00214-3

J. Guhaniyogi and G. Brewer, Regulation of mRNA stability in mammalian cells, Gene, vol.265, issue.1-2, pp.11-23, 2001.
DOI : 10.1016/S0378-1119(01)00350-X

H. R. Herschman, Primary Response Genes Induced by Growth Factors and Tumor Promoters, Annual Review of Biochemistry, vol.60, issue.1, pp.281-319, 1991.
DOI : 10.1146/annurev.bi.60.070191.001433

S. C. Schiavi, J. G. Belasco, and M. E. Greenberg, Regulation of proto-oncogene mRNA stability, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol.1114, issue.2-3, pp.1114-95, 1992.
DOI : 10.1016/0304-419X(92)90009-N

E. Espel, J. A. Garcia-sanz, V. Aubert, V. Menoud, P. Sperisen et al., Transcriptional and translational control of TNF-?? gene expression in human monocytes by major histocompatibility complex class II ligands, European Journal of Immunology, vol.177, issue.10, pp.2417-2424, 1996.
DOI : 10.1002/eji.1830261023

E. K. Crawford, J. E. Ensor, I. Kalvakolanu, and J. D. Hasday, The Role of 3' Poly(A) Tail Metabolism in Tumor Necrosis Factor-?? Regulation, Journal of Biological Chemistry, vol.272, issue.34, pp.21120-21127, 1997.
DOI : 10.1074/jbc.272.34.21120

A. D. Miller, T. Curran, and I. M. Verma, ) c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene, Cell, vol.36, pp.51-60, 1984.

F. Meijlink, T. Curran, A. D. Miller, and I. M. Verma, Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene., Proc. Natl Acad. Sci. USA, pp.4987-4991, 1985.
DOI : 10.1073/pnas.82.15.4987

W. M. Lee, C. Lin, and T. Curran, Activation of the transforming potential of the human fos proto-oncogene requires message stabilization and results in increased amounts of partially modified fos protein., Molecular and Cellular Biology, vol.8, issue.12, pp.5521-5527, 1988.
DOI : 10.1128/MCB.8.12.5521

G. D. Schuler and M. D. Cole, GM-CSF and oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor, Cell, vol.55, issue.6, pp.1115-1122, 1988.
DOI : 10.1016/0092-8674(88)90256-5

J. Keffer, L. Probert, H. Cazlaris, S. Georgopoulos, E. Kaslaris et al., Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis, EMBO J, vol.10, pp.4025-4031, 1991.

K. Keyomarsi and A. B. Pardee, Redundant cyclin overexpression and gene amplification in breast cancer cells., Proc. Natl Acad. Sci. USA, pp.1112-1116, 1993.
DOI : 10.1073/pnas.90.3.1112

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC45821

D. E. Lebwohl, R. Muise-helmericks, L. Sepp-lorenzino, S. Serve, M. Timaul et al., A truncated cyclin D1 gene encodes a stable mRNA in a human breast cancer cell line, Oncogene, vol.9, pp.1925-1929, 1994.

A. P. Nair, S. Hahn, R. Banholzer, H. H. Hirsch, and C. Moroni, Cyclosporin A inhibits growth of autocrine tumour cell lines by destabilizing interleukin-3 mRNA, Nature, vol.369, issue.6477, pp.239-242, 1994.
DOI : 10.1038/369239a0

C. O. Jacob, S. K. Lee, and G. Strassmann, Mutational analysis of TNF-alpha gene reveals a regulatory role for the 3 0 -untranslated region in the genetic predisposition to lupus-like autoimmune disease, J. Immunol, vol.156, pp.3043-3050, 1996.

E. Carballo, W. S. Lai, and P. J. Blackshear, Feedback Inhibition of Macrophage Tumor Necrosis Factor- Production by Tristetraprolin, Science, vol.281, issue.5379, pp.1001-1005, 1998.
DOI : 10.1126/science.281.5379.1001

D. Kontoyiannis, M. Pasparakis, T. T. Pizarro, F. Cominelli, and G. Kollias, Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements, Immunity, vol.10, issue.3, pp.387-398, 1999.
DOI : 10.1016/S1074-7613(00)80038-2

R. Pullmann, . Jr, M. Juhaszova, I. Lopez-de-silanes, T. Kawai et al., Enhanced Proliferation of Cultured Human Vascular Smooth Muscle Cells Linked to Increased Function of RNA-binding Protein HuR, Journal of Biological Chemistry, vol.280, issue.24, pp.22819-22826, 2005.
DOI : 10.1074/jbc.M501106200

B. Conne, A. Stutz, and J. D. Vassalli, The 3 0 untranslated region of messenger RNA: A molecular 'hotspot' for pathology, Nature Medicine, vol.6, issue.6, pp.637-641, 2000.
DOI : 10.1038/76211

Y. Audic and R. S. Hartley, Post-transcriptional regulation in cancer, Biology of the Cell, vol.96, issue.7, pp.479-498, 2004.
DOI : 10.1016/j.biolcel.2004.05.002

D. Caput, B. Beutler, K. Hartog, R. Thayer, S. Brown-shimer et al., Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators., Proc. Natl Acad. Sci. USA, pp.1670-1674, 1986.
DOI : 10.1073/pnas.83.6.1670

T. Bakheet, M. Frevel, B. R. Williams, W. Greer, and K. S. Khabar, ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins, Nucleic Acids Research, vol.29, issue.1, pp.246-254, 2001.
DOI : 10.1093/nar/29.1.246

T. Bakheet, B. R. Williams, and K. S. Khabar, ARED 2.0: an update of AU-rich element mRNA database, Nucleic Acids Research, vol.31, issue.1, pp.421-423, 2003.
DOI : 10.1093/nar/gkg023

C. Y. Chen and A. B. Shyu, AU-rich elements: characterization and importance in mRNA degradation, Trends in Biochemical Sciences, vol.20, issue.11, pp.465-470, 1995.
DOI : 10.1016/S0968-0004(00)89102-1

G. M. Wilson and G. Brewer, The Search for Trans-Acting Factors Controlling Messenger RNA Decay, Prog. Nucleic Acid Res. Mol. Biol, vol.62, pp.257-291, 1999.
DOI : 10.1016/S0079-6603(08)60510-3

G. Shaw and R. Kamen, A conserved AU sequence from the 3??? untranslated region of GM-CSF mRNA mediates selective mRNA degradation, Cell, vol.46, issue.5, pp.659-667, 1986.
DOI : 10.1016/0092-8674(86)90341-7

C. A. Chen, N. Xu, and A. B. Shyu, mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation., Molecular and Cellular Biology, vol.15, issue.10, pp.5777-5788, 1995.
DOI : 10.1128/MCB.15.10.5777

T. Wilson and R. Treisman, Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3??? AU-rich sequences, Nature, vol.336, issue.6197, pp.396-399, 1988.
DOI : 10.1038/336396a0

A. B. Shyu, M. E. Greenberg, and J. G. Belasco, The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways., Genes & Development, vol.3, issue.1, pp.60-72, 1989.
DOI : 10.1101/gad.3.1.60

N. Xu, P. Loflin, C. Y. Chen, and A. B. Shyu, A broader role for AU-rich element-mediated mRNA turnover revealed by a new transcriptional pulse strategy, Nucleic Acids Research, vol.26, issue.2, pp.558-565, 1998.
DOI : 10.1093/nar/26.2.558

C. A. Chen, T. Chen, and A. B. Shyu, Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function., Molecular and Cellular Biology, vol.14, issue.1, pp.416-426, 1994.
DOI : 10.1128/MCB.14.1.416

G. Stoecklin, S. Hahn, and C. Moroni, Functional Hierarchy of AUUUA motifs in mediating rapid interleukin-3 mRNA decay, 1994.

C. A. Chen and A. Shyu, Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements., Molecular and Cellular Biology, vol.14, issue.12, pp.8471-8482, 1994.
DOI : 10.1128/MCB.14.12.8471

C. A. Lagnado, C. Y. Brown, and G. J. Goodall, AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A)., Molecular and Cellular Biology, vol.14, issue.12, pp.7984-7995, 1994.
DOI : 10.1128/MCB.14.12.7984

A. M. Zubiaga, J. G. Belasco, and M. E. Greenberg, The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation., Molecular and Cellular Biology, vol.15, issue.4, pp.2219-2230, 1995.
DOI : 10.1128/MCB.15.4.2219

W. S. Lai, D. M. Carrick, and P. J. Blackshear, Influence of Nonameric AU-rich Tristetraprolin-binding Sites on mRNA Deadenylation and Turnover, Journal of Biological Chemistry, vol.280, issue.40, pp.34365-34377, 2005.
DOI : 10.1074/jbc.M506757200

I. Lopez-de-silanes, M. Zhan, A. Lal, X. Yang, and M. Gorospe, Identification of a target RNA motif for RNA-binding protein HuR, Proc. Natl Acad Sci. USA, pp.2987-2992, 2004.
DOI : 10.1073/pnas.0306453101

I. Lopez-de-silanes, S. Galban, J. L. Martindale, X. Yang, K. Mazan-mamczarz et al., Identification and Functional Outcome of mRNAs Associated with RNA-Binding Protein TIA-1, Molecular and Cellular Biology, vol.25, issue.21, pp.9520-9531, 2005.
DOI : 10.1128/MCB.25.21.9520-9531.2005

S. S. Peng, C. Y. Chen, and A. B. Shyu, Functional characterization of a non-AUUUA AU-rich element from the c-jun proto-oncogene mRNA: evidence for a novel class of AU-rich elements., Molecular and Cellular Biology, vol.16, issue.4, pp.1490-1499, 1996.
DOI : 10.1128/MCB.16.4.1490

N. Xu, C. Chen, and A. Shyu, Versatile Role for hnRNP D Isoforms in the Differential Regulation of Cytoplasmic mRNA Turnover, Molecular and Cellular Biology, vol.21, issue.20, pp.6960-6971, 2001.
DOI : 10.1128/MCB.21.20.6960-6971.2001

C. J. Wilusz, M. Wormington, and S. W. Peltz, The cap-to-tail guide to mRNA turnover, Nature Reviews Molecular Cell Biology, vol.2, issue.4, pp.237-246, 2001.
DOI : 10.1038/35067025

A. Bevilacqua, M. C. Ceriani, S. Capaccioli, and A. Nicolin, Post-transcriptional regulation of gene expression by degradation of messenger RNAs, Journal of Cellular Physiology, vol.15, issue.3, pp.356-372, 2003.
DOI : 10.1002/jcp.10272

G. Brewer and J. Ross, Regulation of c-myc mRNA stability in vitro by a labile destabilizer with an essential nucleic acid component., Molecular and Cellular Biology, vol.9, issue.5, 1989.
DOI : 10.1128/MCB.9.5.1996

G. Brewer, An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro., Molecular and Cellular Biology, vol.11, issue.5, pp.2460-2466, 1991.
DOI : 10.1128/MCB.11.5.2460

W. Zhang, B. J. Wagner, K. Ehrenman, A. W. Schaefer, C. T. Demaria et al., Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1., Molecular and Cellular Biology, vol.13, issue.12, pp.7652-7665, 1993.
DOI : 10.1128/MCB.13.12.7652

A. Lal, K. Mazan-mamczarz, T. Kawai, X. Yang, J. L. Martindale et al., Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs, The EMBO Journal, vol.13, issue.15, pp.3092-3102, 2004.
DOI : 10.1074/jbc.M305775200

G. Dreyfuss, M. J. Matunis, S. Pinol-roma, and C. G. Burd, hnRNP Proteins and the Biogenesis of mRNA, Annual Review of Biochemistry, vol.62, issue.1, pp.289-321, 1993.
DOI : 10.1146/annurev.bi.62.070193.001445

G. Laroia, R. Cuesta, G. Brewer, and R. J. Schneider, Control of mRNA Decay by Heat Shock-Ubiquitin-Proteasome Pathway, Science, vol.284, issue.5413, pp.499-502, 1999.
DOI : 10.1126/science.284.5413.499

A. B. Shyu and M. F. Wilkinson, The Double Lives of Shuttling mRNA Binding Proteins, Cell, vol.102, issue.2, pp.135-138, 2000.
DOI : 10.1016/S0092-8674(00)00018-0

B. Sarkar, J. Y. Lu, and R. J. Schneider, Nuclear Import and Export Functions in the Different Isoforms of the AUF1/Heterogeneous Nuclear Ribonucleoprotein Protein Family, Journal of Biological Chemistry, vol.278, issue.23, pp.20700-20707, 2003.
DOI : 10.1074/jbc.M301176200

P. Loflin, C. Y. Chen, and A. B. Shyu, Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element, Genes & Development, vol.13, issue.14, pp.1884-1897, 1999.
DOI : 10.1101/gad.13.14.1884

B. Sarkar, Q. Xi, C. He, and R. J. Schneider, Selective Degradation of AU-Rich mRNAs Promoted by the p37 AUF1 Protein Isoform, Molecular and Cellular Biology, vol.23, issue.18, pp.6685-6693, 2003.
DOI : 10.1128/MCB.23.18.6685-6693.2003

I. Raineri, D. Wegmueller, B. Gross, U. Certa, and C. Moroni, Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover studied by RNA interference, Nucleic Acids Research, vol.32, issue.4, pp.1279-1288, 2004.
DOI : 10.1093/nar/gkh282

A. Sela-brown, J. Silver, G. Brewer, and T. Naveh-many, Identification of AUF1 as a Parathyroid Hormone mRNA 3'-Untranslated Region-binding Protein That Determines Parathyroid Hormone mRNA Stability, Journal of Biological Chemistry, vol.275, issue.10, pp.7424-7429, 2000.
DOI : 10.1074/jbc.275.10.7424

P. Good, O. Chen, S. Warner, and D. Herring, A Family of Human RNA-binding Proteins Related to the Drosophila Bruno Translational Regulator, Journal of Biological Chemistry, vol.275, issue.37, pp.28583-28592, 2000.
DOI : 10.1074/jbc.M003083200

D. Antic and J. D. Keene, Embryonic Lethal Abnormal Visual RNA-Binding Proteins Involved in Growth, Differentiation, and Posttranscriptional Gene Expression, The American Journal of Human Genetics, vol.61, issue.2, pp.273-278, 1997.
DOI : 10.1086/514866

X. C. Fan and J. A. Steitz, Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the invivo stability of ARE-containing mRNAs, The EMBO Journal, vol.17, issue.12, pp.3448-3460, 1998.
DOI : 10.1093/emboj/17.12.3448

X. C. Fan and J. A. Steitz, HNS, a nuclear-cytoplasmic shuttling sequence in HuR, Proc. Natl Acad. Sci. USA, pp.15293-15298, 1998.
DOI : 10.1073/pnas.95.26.15293

I. E. Gallouzi and J. A. Steitz, Delineation of mRNA Export Pathways by the Use of Cell-Permeable Peptides, Science, vol.294, issue.5548, pp.1895-1901, 2001.
DOI : 10.1126/science.1064693

N. Levy, S. Chung, H. Furneaux, and A. Levy, Hypoxic Stabilization of Vascular Endothelial Growth Factor mRNA by the RNA-binding Protein HuR, Journal of Biological Chemistry, vol.273, issue.11, pp.6417-6423, 1998.
DOI : 10.1074/jbc.273.11.6417

S. S. Peng, C. Y. Chen, N. Xu, and A. B. Shyu, RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein, The EMBO Journal, vol.17, issue.12, pp.3461-3470, 1998.
DOI : 10.1093/emboj/17.12.3461

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170682

F. Rodriguez-pascual, M. Hausding, I. Ihrig-biedert, H. Furneaux, A. P. Levy et al., Complex Contribution of the 3'-Untranslated Region to the Expressional Regulation of the Human Inducible Nitric-oxide Synthase Gene. INVOLVEMENT OF THE RNA-BINDING PROTEIN HuR, Journal of Biological Chemistry, vol.275, issue.34, pp.26040-26049, 2000.
DOI : 10.1074/jbc.M910460199

J. L. Dean, R. Wait, K. R. Mahtani, G. Sully, A. R. Clark et al., The 3' Untranslated Region of Tumor Necrosis Factor Alpha mRNA Is a Target of the mRNA-Stabilizing Factor HuR, Molecular and Cellular Biology, vol.21, issue.3, pp.721-730, 2001.
DOI : 10.1128/MCB.21.3.721-730.2001

X. F. Ming, G. Stoecklin, M. Lu, R. Looser, and C. Moroni, Parallel and Independent Regulation of Interleukin-3 mRNA Turnover by Phosphatidylinositol 3-Kinase and p38 Mitogen-Activated Protein Kinase, Molecular and Cellular Biology, vol.21, issue.17, pp.5778-5789, 2001.
DOI : 10.1128/MCB.21.17.5778-5789.2001

C. Y. Chen, N. Xu, and A. B. Shyu, Highly Selective Actions of HuR in Antagonizing AU-Rich Element-Mediated mRNA Destabilization, Molecular and Cellular Biology, vol.22, issue.20, pp.7268-7278, 2002.
DOI : 10.1128/MCB.22.20.7268-7278.2002

A. Figueroa, A. Cuadrado, J. Fan, U. Atasoy, G. E. Muscat et al., Role of HuR in Skeletal Myogenesis through Coordinate Regulation of Muscle Differentiation Genes, Molecular and Cellular Biology, vol.23, issue.14, pp.4991-5004, 2003.
DOI : 10.1128/MCB.23.14.4991-5004.2003

W. Wang, H. Furneaux, H. Cheng, M. C. Caldwell, D. Hutter et al., HuR Regulates p21 mRNA Stabilization by UV Light, Molecular and Cellular Biology, vol.20, issue.3, pp.760-769, 2000.
DOI : 10.1128/MCB.20.3.760-769.2000

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC85192

W. Wang, M. C. Caldwell, S. Lin, H. Furneaux, and M. Gorospe, HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation, The EMBO Journal, vol.14, issue.10, pp.2340-2350, 2000.
DOI : 10.1093/emboj/19.10.2340

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC384372

S. Sengupta, B. C. Jang, M. T. Wu, J. H. Paik, H. Furneaux et al., The RNA-binding Protein HuR Regulates the Expression of Cyclooxygenase-2, Journal of Biological Chemistry, vol.278, issue.27, pp.25227-25233, 2003.
DOI : 10.1074/jbc.M301813200

R. G. Jain, L. G. Andrews, K. M. Mcgowan, P. H. Pekala, and J. D. Keene, Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes., Molecular and Cellular Biology, vol.17, issue.2, pp.954-962, 1997.
DOI : 10.1128/MCB.17.2.954

D. Antic, N. Lu, and J. D. Keene, ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells, Genes & Development, vol.13, issue.4, pp.449-461, 1999.
DOI : 10.1101/gad.13.4.449

L. P. Ford, J. Watson, J. D. Keene, and J. Wilusz, ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system, Genes & Development, vol.13, issue.2, pp.188-201, 1999.
DOI : 10.1101/gad.13.2.188

C. D. Mobarak, K. D. Anderson, M. Morin, A. Beckel-mitchener, S. L. Rogers et al., The RNA-binding Protein HuD Is Required for GAP-43 mRNA Stability, GAP-43 Gene Expression, and PKC-dependent Neurite Outgrowth in PC12 Cells, Molecular Biology of the Cell, vol.11, issue.9, pp.3191-3203, 2000.
DOI : 10.1091/mbc.11.9.3191

K. D. Anderson, M. A. Morin, A. Beckel-mitchener, C. D. Mobarak, R. L. Neve et al., Overexpression of HuD, but Not of Its Truncated Form HuD I+II, Promotes GAP-43 Gene Expression and Neurite Outgrowth in PC12 Cells in the Absence of Nerve Growth Factor, Journal of Neurochemistry, vol.244, issue.3, pp.1103-1114, 2000.
DOI : 10.1046/j.1471-4159.2000.0751103.x

A. C. Beckel-mitchener, A. Miera, R. Keller, and N. I. Perrone-bizzozero, Poly(A) Tail Length-dependent Stabilization of GAP-43 mRNA by the RNA-binding Protein HuD, Journal of Biological Chemistry, vol.277, issue.31, pp.27996-28002, 2002.
DOI : 10.1074/jbc.M201982200

P. H. King, RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'-untranslated regions using a novel ELISA-based assay, Nucleic Acids Research, vol.28, issue.7, p.20, 2000.
DOI : 10.1093/nar/28.7.e20

H. Cao, J. S. Tuttle, and P. J. Blackshear, Immunological Characterization of Tristetraprolin as a Low Abundance, Inducible, Stable Cytosolic Protein, Journal of Biological Chemistry, vol.279, issue.20, pp.21489-21499, 2004.
DOI : 10.1074/jbc.M400900200

E. Carballo, G. S. Gilkeson, and P. J. Blackshear, Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (-/-) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNFalpha overproduction., Journal of Clinical Investigation, vol.100, issue.5, pp.986-995, 1997.
DOI : 10.1172/JCI119649

E. Carballo, W. S. Lai, and P. J. Blackshear, Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability, Blood, vol.95, pp.1891-1899, 2000.

R. L. Ogilvie, M. Abelson, H. H. Hau, I. Vlasova, P. J. Blackshear et al., Tristetraprolin Down-Regulates IL-2 Gene Expression through AU-Rich Element-Mediated mRNA Decay, The Journal of Immunology, vol.174, issue.2, 2005.
DOI : 10.4049/jimmunol.174.2.953

W. S. Lai and P. J. Blackshear, Interactions of CCCH Zinc Finger Proteins with mRNA: TRISTETRAPROLIN-MEDIATED AU-RICH ELEMENT-DEPENDENT mRNA DEGRADATION CAN OCCUR IN THE ABSENCE OF A POLY(A) TAIL, Journal of Biological Chemistry, vol.276, issue.25, pp.23144-23154, 2001.
DOI : 10.1074/jbc.M100680200

W. S. Lai, E. A. Kennington, and P. J. Blackshear, Interactions of CCCH Zinc Finger Proteins with mRNA: NON-BINDING TRISTETRAPROLIN MUTANTS EXERT AN INHIBITORY EFFECT ON DEGRADATION OF AU-RICH ELEMENT-CONTAINING mRNAs, Journal of Biological Chemistry, vol.277, issue.11, pp.9606-9613, 2002.
DOI : 10.1074/jbc.M110395200

W. S. Lai, E. A. Kennington, and P. J. Blackshear, Tristetraprolin and Its Family Members Can Promote the Cell-Free Deadenylation of AU-Rich Element-Containing mRNAs by Poly(A) Ribonuclease, Molecular and Cellular Biology, vol.23, issue.11, pp.3798-3812, 2003.
DOI : 10.1128/MCB.23.11.3798-3812.2003

W. S. Lai, E. Carballo, J. R. Strum, E. A. Kennington, R. S. Phillips et al., Evidence that Tristetraprolin Binds to AU-Rich Elements and Promotes the Deadenylation and Destabilization of Tumor Necrosis Factor Alpha mRNA, Molecular and Cellular Biology, vol.19, issue.6, pp.4311-4323, 1999.
DOI : 10.1128/MCB.19.6.4311

H. Sawaoka, D. A. Dixon, J. A. Oates, and O. Boutaud, Tristetraprolin Binds to the 3'-Untranslated Region of Cyclooxygenase-2 mRNA: A POLYADENYLATION VARIANT IN A CANCER CELL LINE LACKS THE BINDING SITE, Journal of Biological Chemistry, vol.278, issue.16, pp.13928-13935, 2003.
DOI : 10.1074/jbc.M300016200

G. Stoecklin, X. F. Ming, R. Looser, and C. Moroni, Somatic mRNA Turnover Mutants Implicate Tristetraprolin in the Interleukin-3 mRNA Degradation Pathway, Molecular and Cellular Biology, vol.20, issue.11, pp.3753-3763, 2000.
DOI : 10.1128/MCB.20.11.3753-3763.2000

W. S. Lai, E. Carballo, J. M. Thorn, E. A. Kennington, and P. J. Blackshear, Interactions of CCCH Zinc Finger Proteins with mRNA: BINDING OF TRISTETRAPROLIN-RELATED ZINC FINGER PROTEINS TO AU-RICH ELEMENTS AND DESTABILIZATION OF mRNA, Journal of Biological Chemistry, vol.275, issue.23, pp.17827-17837, 2000.
DOI : 10.1074/jbc.M001696200

C. Y. Chen, R. Gherzi, S. E. Ong, E. L. Chan, R. Raijmakers et al., AU Binding Proteins Recruit the Exosome to Degrade ARE-Containing mRNAs, Cell, vol.107, issue.4, pp.451-464, 2001.
DOI : 10.1016/S0092-8674(01)00578-5

J. Lykke-andersen and E. Wagner, Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1, Genes & Development, vol.19, issue.3, pp.351-361, 2005.
DOI : 10.1101/gad.1282305

G. Stoecklin, M. Colombi, I. Raineri, S. Leuenberger, M. Mallaun et al., Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover, The EMBO Journal, vol.21, issue.17, pp.4709-4718, 2002.
DOI : 10.1093/emboj/cdf444

R. Gherzi, K. Y. Lee, P. Briata, D. Wegmuller, C. Moroni et al., A KH Domain RNA Binding Protein, KSRP, Promotes ARE-Directed mRNA Turnover by Recruiting the Degradation Machinery, Molecular Cell, vol.14, issue.5, pp.571-583, 2004.
DOI : 10.1016/j.molcel.2004.05.002

G. M. Wilson, J. Lu, K. Sutphen, Y. Suarez, S. Sinha et al., Phosphorylation of p40AUF1 Regulates Binding to A + U-rich mRNA-destabilizing Elements and Protein-induced Changes in Ribonucleoprotein Structure, Journal of Biological Chemistry, vol.278, issue.35, pp.33039-33048, 2003.
DOI : 10.1074/jbc.M305775200

J. Y. Lu and R. J. Schneider, Tissue Distribution of AU-rich mRNA-binding Proteins Involved in Regulation of mRNA Decay, Journal of Biological Chemistry, vol.279, issue.13, 2004.
DOI : 10.1074/jbc.M310433200

I. E. Gallouzi, C. M. Brennan, M. G. Stenberg, M. S. Swanson, A. Eversole et al., HuR binding to cytoplasmic mRNA is perturbed by heat shock, Proc. Natl Acad. Sci. USA, pp.3073-3078, 2000.
DOI : 10.1073/pnas.97.7.3073

C. Grosset, C. Y. Chen, N. Xu, N. Sonenberg, H. Jacquemin-sablon et al., A Mechanism for Translationally Coupled mRNA Turnover, Cell, vol.103, issue.1, pp.29-40, 2000.
DOI : 10.1016/S0092-8674(00)00102-1

U. Atasoy, J. Watson, D. Patel, and J. D. Keene, ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation, 1998.

S. Galban, J. L. Martindale, K. Mazan-mamczarz, I. Lopez-de-silanes, J. Fan et al., Influence of the RNA-Binding Protein HuR in pVHL-Regulated p53 Expression in Renal Carcinoma Cells, Molecular and Cellular Biology, vol.23, issue.20, pp.7083-7095, 2003.
DOI : 10.1128/MCB.23.20.7083-7095.2003

Y. Seko, H. Azmi, R. Fariss, and J. A. Ragheb, Selective Cytoplasmic Translocation of HuR and Site-specific Binding to the Interleukin-2 mRNA Are Not Sufficient for CD28-mediated Stabilization of the mRNA, Journal of Biological Chemistry, vol.279, issue.32, pp.33359-33367, 2004.
DOI : 10.1074/jbc.M312306200

A. Raghavan, R. L. Robison, J. Mcnabb, C. R. Miller, D. A. Williams et al., HuA and tristetraprolin are induced following T cell activation and display distinct but overlapping RNA binding specificities, J. Biol. Chem, vol.276, pp.47958-47965, 2001.

K. Linker, A. Pautz, M. Fechir, T. Hubrich, J. Greeve et al., Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR, Nucleic Acids Research, vol.33, issue.15, pp.4813-4827, 2005.
DOI : 10.1093/nar/gki797

M. Fechir, K. Linker, A. Pautz, T. Hubrich, U. Forstermann et al., Tristetraprolin Regulates the Expression of the Human Inducible Nitric-Oxide Synthase Gene, Molecular Pharmacology, vol.67, issue.6, pp.2148-2161, 2005.
DOI : 10.1124/mol.104.008763

C. A. Beelman and R. Parker, Degradation of mRNA in eukaryotes, Cell, vol.81, issue.2, pp.179-183, 1995.
DOI : 10.1016/0092-8674(95)90326-7

A. P. Lieberman, P. M. Pitha, and M. L. Shin, Poly(A) removal is the kinase-regulated step in tumor necrosis factor mRNA decay, J. Biol. Chem, vol.267, pp.2123-2126, 1992.

K. Peppel and C. Baglioni, Deadenylation and turnover of interferon-beta mRNA, J. Biol. Chem, vol.266, pp.6663-6666, 1991.

I. A. Laird-offringa, C. L. De-wit, P. Elfferich, and A. J. Van-der-eb, Poly(A) tail shortening is the translation-dependent step in c-myc mRNA degradation., Molecular and Cellular Biology, vol.10, issue.12, pp.6132-6140, 1990.
DOI : 10.1128/MCB.10.12.6132

A. B. Shyu, J. G. Belasco, and M. E. Greenberg, Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay., Genes & Development, vol.5, issue.2, pp.221-231, 1991.
DOI : 10.1101/gad.5.2.221

G. Brewer and J. Ross, Poly(A) shortening and degradation of the 3' A+U-rich sequences of human c-myc mRNA in a cell-free system., Molecular and Cellular Biology, vol.8, issue.4, pp.1697-1708, 1988.
DOI : 10.1128/MCB.8.4.1697

P. Couttet, M. Fromont-racine, D. Steel, R. Pictet, and T. Grange, Messenger RNA deadenylation preceeds decapping in mammalian cells, Proc. Natl Acad. Sci. USA, pp.5628-5633, 1997.

D. Mukherjee, M. Gao, J. P. O-'connor, R. Raijmakers, G. Pruijn et al., The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements, The EMBO Journal, vol.21, issue.1, 2002.
DOI : 10.1093/emboj/21.1.165

N. Kedersha, G. Stoecklin, M. Ayodele, P. Yacono, J. Lykke-andersen et al., Stress granules and processing bodies are dynamically linked sites of mRNP remodeling, The Journal of Cell Biology, vol.20, issue.6, pp.871-884, 2005.
DOI : 10.1242/jcs.01477

J. S. Butler, The yin and yang of the exosome, Trends in Cell Biology, vol.12, issue.2, pp.90-96, 2002.
DOI : 10.1016/S0962-8924(01)02225-5

U. Sheth and R. Parker, Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies, Science, vol.300, issue.5620, pp.805-808, 2003.
DOI : 10.1126/science.1082320

D. Ingelfinger, D. J. Arndt-jovin, R. Luhrmann, and T. Achsel, The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci, RNA, vol.8, pp.1489-1501, 2002.

T. Eystathioy, A. Jakymiw, E. K. Chan, B. Seraphin, N. Cougot et al., The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies, RNA, vol.9, issue.10, pp.1171-1173, 2003.
DOI : 10.1261/rna.5810203

N. Cougot, S. Babajko, and B. Seraphin, Cytoplasmic foci are sites of mRNA decay in human cells, The Journal of Cell Biology, vol.115, issue.1, pp.31-40, 2004.
DOI : 10.1016/S0962-8924(01)01982-1

A. Wilczynska, C. Aigueperse, M. Kress, F. Dautry, and D. Weil, The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules, Journal of Cell Science, vol.118, issue.5, pp.981-992, 2005.
DOI : 10.1242/jcs.01692

N. Kedersha and P. Anderson, Stress granules: sites of mRNA triage that regulate mRNA stability and translatability, Biochemical Society Transactions, vol.30, issue.6, pp.963-969, 2002.
DOI : 10.1042/bst0300963

M. Piecyk, S. Wax, A. R. Beck, N. Kedersha, M. Gupta et al., TIA-1 is a translational silencer that selectively regulates the expression of TNF-??, The EMBO Journal, vol.13, issue.15, pp.4154-4163, 2000.
DOI : 10.1093/emboj/19.15.4154

D. A. Dixon, G. C. Balch, N. Kedersha, P. Anderson, G. A. Zimmerman et al., Regulation of Cyclooxygenase-2 Expression by the Translational Silencer TIA-1, The Journal of Experimental Medicine, vol.62, issue.3, pp.475-481, 2003.
DOI : 10.1074/jbc.M109511200

M. Gao, C. J. Wilusz, S. W. Peltz, and J. Wilusz, A novel mRNA-decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elements, The EMBO Journal, vol.20, issue.5, pp.1134-1143, 2001.
DOI : 10.1093/emboj/20.5.1134

E. Winstall, M. Gamache, R. , and V. , Rapid mRNA degradation mediated by the c-fos 3' AU-rich element and that mediated by the granulocyte-macrophage colony-stimulating factor 3' AU-rich element occur through similar polysome-associated mechanisms., Molecular and Cellular Biology, vol.15, issue.7, pp.3796-3804, 1995.
DOI : 10.1128/MCB.15.7.3796

A. Jacobson and S. W. Peltz, Interrelationships of the Pathways of mRNA Decay and Translation in Eukaryotic Cells, Annual Review of Biochemistry, vol.65, issue.1, pp.693-739, 1996.
DOI : 10.1146/annurev.bi.65.070196.003401

S. Savant-bhonsale, C. , and D. W. , Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex., Genes & Development, vol.6, issue.10, pp.1927-1939, 1992.
DOI : 10.1101/gad.6.10.1927

T. Aharon and R. J. Schneider, Selective destabilization of shortlived mRNAs with the granulocyte-macrophage colony-stimulating factor AU-rich 3 0 noncoding region is mediated by a cotranslational mechanism, Mol. Cell Biol, vol.13, 1971.

A. M. Curatola, M. S. Nadal, and R. J. Schneider, Rapid degradation of AU-rich element (ARE) mRNAs is activated by ribosome transit and blocked by secondary structure at any position 5' to the ARE., Molecular and Cellular Biology, vol.15, issue.11, pp.6331-6340, 1995.
DOI : 10.1128/MCB.15.11.6331

D. M. Koeller, J. A. Horowitz, J. L. Casey, R. D. Klausner, and J. B. Harford, Translation and the stability of mRNAs encoding the transferrin receptor and c-fos., Proc. Natl Acad. Sci. USA, pp.7778-7782, 1991.
DOI : 10.1073/pnas.88.17.7778

X. C. Fan, V. E. Myer, and J. A. Steitz, AU-rich elemetns target small nuclear RNAs as well as mRNAs for rapid degradation, 1997.

N. Kedersha, M. R. Cho, W. Li, P. W. Yacono, S. Chen et al., Dynamic Shuttling of Tia-1 Accompanies the Recruitment of mRNA to Mammalian Stress Granules, The Journal of Cell Biology, vol.18, issue.6, pp.1257-1268, 2000.
DOI : 10.1093/emboj/16.6.1401

V. Kruys, M. Wathelet, P. Poupart, R. Contreras, W. Fiers et al., The 3 0 untranslated region of the human interferonbeta mRNA has an inhibitory effect on translation, Proc. Natl Acad. Sci. USA, pp.6030-6034, 1987.

G. Grafi, I. Sela, and G. Galili, Translational regulation of human beta interferon mRNA: association of the 3' AU-rich sequence with the poly(A) tail reduces translation efficiency in vitro., Molecular and Cellular Biology, vol.13, issue.6, pp.3487-3493, 1993.
DOI : 10.1128/MCB.13.6.3487

V. Kruys, O. Marinx, G. Shaw, J. Deschamps, and G. Huez, Translational blockade imposed by cytokine-derived UA-rich sequences, Science, vol.245, issue.4920, pp.852-855, 1989.
DOI : 10.1126/science.2672333

J. Han and B. Beutler, The essential role of the UA-rich sequence in endotoxin-induced cachectin/TNF synthesis, Eur. Cytokine Netw, vol.1, pp.71-75, 1990.

J. Han, T. Brown, and B. Beutler, Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level [published erratum appears in J Exp Med 1990 Mar 1;171(3):971-2], Journal of Experimental Medicine, vol.171, issue.2, pp.465-475, 1990.
DOI : 10.1084/jem.171.2.465

B. Beutler, N. Krochin, I. W. Milsark, C. Luedke, and A. Cerami, Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance, Science, vol.232, issue.4753, pp.977-980, 1986.
DOI : 10.1126/science.3754653

K. Mazan-mamczarz, S. Galban, I. Lopez-de-silanes, J. L. Martindale, U. Atasoy et al., RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation, Proc. Natl Acad. Sci. USA, pp.8354-8359, 2003.
DOI : 10.1073/pnas.1432104100

C. Grosset, R. Boniface, P. Duchez, A. Solanilla, B. Cosson et al., In Vivo Studies of Translational Repression Mediated by the Granulocyte-Macrophage Colony-stimulating Factor AU-rich Element, Journal of Biological Chemistry, vol.279, issue.14, pp.13354-13362, 2004.
DOI : 10.1074/jbc.M308003200

V. Katsanou, O. Papadaki, S. Milatos, P. J. Blackshear, P. Anderson et al., HuR as a Negative Posttranscriptional Modulator in Inflammation, Molecular Cell, vol.19, issue.6, pp.777-789, 2005.
DOI : 10.1016/j.molcel.2005.08.007

L. Paillard and H. B. Osborne, East of EDEN was a poly(A) tail, Biology of the Cell, vol.95, issue.3-4, pp.211-219, 2003.
DOI : 10.1016/S0248-4900(03)00038-8

URL : https://hal.archives-ouvertes.fr/hal-00982686

D. A. Mangus, M. C. Evans, and A. Jacobson, Poly(A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression, Genome Biology, vol.4, issue.7, p.223, 2003.
DOI : 10.1186/gb-2003-4-7-223

A. C. Gingras, B. Raught, and N. Sonenberg, eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation, Annual Review of Biochemistry, vol.68, issue.1, pp.913-963, 1999.
DOI : 10.1146/annurev.biochem.68.1.913

A. M. Borman, Y. M. Michel, and K. M. Kean, Biochemical characterisation of cap-poly(A) synergy in rabbit reticulocyte lysates: the eIF4G-PABP interaction increases the functional affinity of eIF4E for the capped mRNA 5'-end, Nucleic Acids Research, vol.28, issue.21, pp.4068-4075, 2000.
DOI : 10.1093/nar/28.21.4068

A. Kahvejian, Y. V. Svitkin, R. Sukarieh, M. N. Boutchou, and N. Sonenberg, Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms, Genes & Development, vol.19, issue.1, pp.104-113, 2005.
DOI : 10.1101/gad.1262905

C. H. De-moor, H. Meijer, and S. Lissenden, Mechanisms of translational control by the 3??? UTR in development and differentiation, Seminars in Cell & Developmental Biology, vol.16, issue.1, pp.49-58, 2005.
DOI : 10.1016/j.semcdb.2004.11.007

L. Nover, K. D. Scharf, and D. Neumann, Cytoplasmic heat shock granules are formed from precursor particles and are associated with a specific set of mRNAs., Molecular and Cellular Biology, vol.9, issue.3, pp.1298-1308, 1989.
DOI : 10.1128/MCB.9.3.1298

A. G. West and P. Fraser, Remote control of gene transcription, Human Molecular Genetics, vol.14, issue.suppl_1, pp.101-111, 2005.
DOI : 10.1093/hmg/ddi104

D. Bentley, The mRNA assembly line: transcription and processing machines in the same factory, Current Opinion in Cell Biology, vol.14, issue.3, pp.336-342, 2002.
DOI : 10.1016/S0955-0674(02)00333-2

A. I. Lamond and D. L. Spector, Nuclear speckles: a model for nuclear organelles, Nature Reviews Molecular Cell Biology, vol.4, issue.8, pp.605-612, 2003.
DOI : 10.1038/nrm1172

D. Mukhopadhyay, C. W. Houchen, S. Kennedy, B. K. Dieckgraefe, and S. Anant, Coupled mRNA Stabilization and Translational Silencing of Cyclooxygenase-2 by a Novel RNA Binding Protein, CUGBP2, Molecular Cell, vol.11, issue.1, pp.113-126, 2003.
DOI : 10.1016/S1097-2765(03)00012-1

C. Y. Chen, N. Xu, W. Zhu, and A. B. Shyu, Functional dissection of hnRNP D suggests that nuclear import is required before hnRNP D can modulate mRNA turnover in the cytoplasm, RNA, vol.10, issue.4, pp.669-680, 2004.
DOI : 10.1261/rna.5269304

N. L. Kedersha, M. Gupta, W. Li, I. Miller, and P. Anderson, RNA-Binding Proteins Tia-1 and Tiar Link the Phosphorylation of Eif-2?? to the Assembly of Mammalian Stress Granules, The Journal of Cell Biology, vol.18, issue.7, pp.1431-1442, 1999.
DOI : 10.1042/bst0250509

L. Paillard, V. Legagneux, D. Maniey, and H. B. Osborne, c-Jun ARE Targets mRNA Deadenylation by an EDEN-BP (Embryo Deadenylation Element-binding Protein)-dependent Pathway, Journal of Biological Chemistry, vol.277, issue.5, 2002.
DOI : 10.1074/jbc.M109362200

URL : https://hal.archives-ouvertes.fr/inserm-00292952

C. T. Demaria and G. Brewer, AUF1 Binding Affinity to A+U-rich Elements Correlates with Rapid mRNA Degradation, Journal of Biological Chemistry, vol.271, issue.21, pp.12179-12184, 1996.
DOI : 10.1074/jbc.271.21.12179

W. J. Ma, S. Cheng, C. Campbell, A. Wright, and H. Furneaux, Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein, J. Biol. Chem, vol.271, pp.8144-8151, 1996.

W. J. Ma, S. Chung, and H. Furneaux, The Elav-like proteins bind to AU-rich elements and to the poly(A) tail of mRNA, Nucleic Acids Research, vol.25, issue.18, pp.3564-3569, 1997.
DOI : 10.1093/nar/25.18.3564

T. D. Levine, F. Gao, P. H. King, L. G. Andrews, and J. D. Keene, Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs., Molecular and Cellular Biology, vol.13, issue.6, pp.3494-3504, 1993.
DOI : 10.1128/MCB.13.6.3494

J. Nakagawa, H. Waldner, S. Meyer-monard, J. Hofsteenge, P. Jeno et al., AUH, a gene encoding an AU-specific RNA binding protein with intrinsic enoyl-CoA hydratase activity., Proc. Natl Acad. Sci. USA, pp.2051-2055, 1995.
DOI : 10.1073/pnas.92.6.2051

T. Henics, E. Nagy, H. J. Oh, P. Csermely, A. Von-gabain et al., Mammalian Hsp70 and Hsp110 Proteins Bind to RNA Motifs Involved in mRNA Stability, Journal of Biological Chemistry, vol.274, issue.24, pp.17318-17324, 1999.
DOI : 10.1074/jbc.274.24.17318

J. Liu, J. Dalmau, A. Szabo, M. Rosenfeld, J. Huber et al., Paraneoplastic Encephalomyelitis Antigens Bind to the AU-rich Elements of mRNA, Neurology, vol.45, issue.3, pp.544-550, 1995.
DOI : 10.1212/WNL.45.3.544

S. Chung, L. Jiang, S. Cheng, and H. Furneaux, Purification and properties of HuD, a neuronal RNA-binding protein, J. Biol. Chem, vol.271, pp.11518-11524, 1996.

A. Pende, K. D. Tremmel, C. T. Demaria, B. C. Blaxall, W. A. Minobe et al., Regulation of the mRNA-binding protein AUF1 by activation of the beta-adrenergic receptor signal transduction pathway, J. Biol. Chem, vol.271, pp.8493-8501, 1996.

E. Nagy and W. F. Rigby, Glyceraldehyde-3-phosphate Dehydrogenase Selectively Binds AU-rich RNA in the NAD+-binding Region (Rossmann Fold), Journal of Biological Chemistry, vol.270, issue.6, pp.2755-2763, 1995.
DOI : 10.1074/jbc.270.6.2755

B. Joseph, M. Orlian, and H. Furneaux, (waf1) mRNA contains a conserved element in its 3 0 -untranslated region that is bound by the Elav-like mRNA-stabilizing proteins, J. Biol. Chem, vol.273, pp.21-20511, 1998.

S. Lin, W. Wang, G. M. Wilson, X. Yang, G. Brewer et al., Down-Regulation of Cyclin D1 Expression by Prostaglandin A2 Is Mediated by Enhanced Cyclin D1 mRNA Turnover, Molecular and Cellular Biology, vol.20, issue.21, pp.7903-7913, 2000.
DOI : 10.1128/MCB.20.21.7903-7913.2000

F. Maurer, M. Tierney, and R. L. Medcalf, An AU-rich sequence in the 3'-UTR of plasminogen activator inhibitor type 2 (PAI-2) mRNA promotes PAI-2 mRNA decay and provides a binding site for nuclear HuR, Nucleic Acids Research, vol.27, issue.7, pp.1664-1673, 1999.
DOI : 10.1093/nar/27.7.1664

S. Bhattacharya, T. Giordano, G. Brewer, and J. S. Malter, Identification of AUF-1 ligands reveals vast diversity of early response gene mRNAs, Nucleic Acids Research, vol.27, issue.6, pp.1464-1472, 1999.
DOI : 10.1093/nar/27.6.1464

B. J. Hamilton, E. Nagy, J. S. Malter, B. A. Arrick, and W. F. Rigby, Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences, J. Biol. Chem, vol.268, pp.8881-8887, 1993.

G. M. Wilson, Y. Sun, H. Lu, and G. Brewer, Assembly of AUF1 Oligomers on U-rich RNA Targets by Sequential Dimer Association, Journal of Biological Chemistry, vol.274, issue.47, pp.33374-33381, 1999.
DOI : 10.1074/jbc.274.47.33374

C. Gueydan, L. Droogmans, P. Chalon, G. Huez, D. Caput et al., Identification of TIAR as a Protein Binding to the Translational Regulatory AU-rich Element of Tumor Necrosis Factor ?? mRNA, Journal of Biological Chemistry, vol.274, issue.4, pp.2322-2326, 1999.
DOI : 10.1074/jbc.274.4.2322

M. Lasa, K. R. Mahtani, A. Finch, G. Brewer, J. Saklatvala et al., Regulation of Cyclooxygenase 2 mRNA Stability by the Mitogen-Activated Protein Kinase p38 Signaling Cascade, Molecular and Cellular Biology, vol.20, issue.12, pp.4265-4274, 2000.
DOI : 10.1128/MCB.20.12.4265-4274.2000

S. J. Cok, S. J. Acton, A. E. Sexton, and A. R. Morrison, Identification of RNA-binding Proteins in RAW 264.7 Cells That Recognize a Lipopolysaccharide-responsive Element in the 3-Untranslated Region of the Murine Cyclooxygenase-2 mRNA, Journal of Biological Chemistry, vol.279, issue.9, pp.8196-8205, 2004.
DOI : 10.1074/jbc.M308475200

D. A. Dixon, N. D. Tolley, P. H. King, L. B. Nabors, T. M. Mcintyre et al., Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells, Journal of Clinical Investigation, vol.108, issue.11, pp.1657-1665, 2001.
DOI : 10.1172/JCI12973

A. Lapucci, M. Donnini, L. Papucci, E. Witort, A. Tempestini et al., AUF1 Is a bcl-2 A + U-rich Element-binding Protein Involved in bcl-2 mRNA Destabilization during Apoptosis, Journal of Biological Chemistry, vol.277, issue.18, pp.16139-16146, 2002.
DOI : 10.1074/jbc.M201377200

T. K. Sengupta, S. Bandyopadhyay, D. J. Fernandes, and E. K. Spicer, Identification of Nucleolin as an AU-rich Element Binding Protein Involved in bcl-2 mRNA Stabilization, Journal of Biological Chemistry, vol.279, issue.12, pp.10855-10863, 2004.
DOI : 10.1074/jbc.M309111200

M. Donnini, A. Lapucci, L. Papucci, E. Witort, A. Jacquier et al., Identification of TINO, Journal of Biological Chemistry, vol.279, issue.19, pp.20154-20166, 2004.
DOI : 10.1074/jbc.M314071200

C. Onesto, E. Berra, R. Grepin, and G. Pages, Poly(A)-binding Protein-interacting Protein 2, a Strong Regulator of Vascular Endothelial Growth Factor mRNA, Journal of Biological Chemistry, vol.279, issue.33, pp.34217-34226, 2004.
DOI : 10.1074/jbc.M400219200

URL : https://hal.archives-ouvertes.fr/hal-00323613

B. J. Hamilton, R. C. Nichols, H. Tsukamoto, R. J. Boado, W. M. Pardridge et al., hnRNP A2 and hnRNP L Bind the 3???UTR of Glucose Transporter 1 mRNA and Exist as a Complex in Vivo, Biochemical and Biophysical Research Communications, vol.261, issue.3, pp.646-651, 1999.
DOI : 10.1006/bbrc.1999.1040

P. H. King, T. D. Levine, R. T. Fremeau, . Jr, and J. D. Keene, Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3 0 UTR of mRNA encoding the Id transcriptional repressor, J. Neurosci, vol.14, pp.1943-1952, 1994.

S. Chung, M. Eckrich, N. Perrone-bizzozero, D. T. Kohn, and H. Furneaux, The Elav-like Proteins Bind to a Conserved Regulatory Element in the 3'-Untranslated Region of GAP-43 mRNA, Journal of Biological Chemistry, vol.272, issue.10, pp.6593-6598, 1997.
DOI : 10.1074/jbc.272.10.6593

I. E. Gallouzi, C. M. Brennan, and J. A. Steitz, Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock, RNA, vol.7, issue.9, pp.1348-1361, 2001.
DOI : 10.1017/S1355838201016089