The protein C pathway, Chest, vol.124, pp.36-68, 2003. ,
Interactions between the innate immune and blood coagulation systems, Trends in Immunology, vol.25, issue.10, pp.536-578, 2004. ,
DOI : 10.1016/j.it.2004.08.003
Thrombomodulin-protein C-EPCR system ,
Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor, J Biol Chem, vol.269, pp.26486-91, 1994. ,
Human Protein C Receptor Is Present Primarily on Endothelium of Large Blood Vessels : Implications for the Control of the Protein C Pathway, Circulation, vol.96, issue.10, pp.3633-3673, 1997. ,
DOI : 10.1161/01.CIR.96.10.3633
The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex., Proceedings of the National Academy of Sciences, vol.93, issue.19, pp.10212-10218, 1996. ,
DOI : 10.1073/pnas.93.19.10212
Isolation of a membrane-bound cofactor for thrombincatalyzed activation of protein C, J Biol Chem, vol.257, pp.859-64, 1982. ,
Endothelial cell protein C receptor plays an important role in protein C activation in vivo, Blood, vol.97, issue.6, pp.1685-1693, 2001. ,
DOI : 10.1182/blood.V97.6.1685
Disruption of the Endothelial Cell Protein C Receptor Gene in Mice Causes Placental Thrombosis and Early Embryonic Lethality, Journal of Biological Chemistry, vol.277, issue.45, pp.43335-43378, 2002. ,
DOI : 10.1074/jbc.M207538200
The endothelial protein C receptor, Current Opinion in Hematology, vol.13, issue.5, pp.382-387, 2006. ,
DOI : 10.1097/01.moh.0000239712.93662.35
Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: comparison with the structure of CD1/major histocompatibility complex alpha1 and alpha2 domains, Blood, vol.94, pp.632-673, 1999. ,
Endothelial Cell Protein C Receptor Acts as a Cellular Receptor for Factor VIIa on Endothelium, Journal of Biological Chemistry, vol.282, issue.16, pp.11849-57, 2007. ,
DOI : 10.1074/jbc.M609283200
Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity, Journal of Thrombosis and Haemostasis, vol.267, issue.9, pp.1817-1841, 2007. ,
DOI : 10.1111/j.1538-7836.2007.02648.x
Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis, Journal of Biological Chemistry, vol.276, issue.14, pp.11199-203, 2001. ,
DOI : 10.1074/jbc.C100017200
PAR1 Cleavage and Signaling in Response to Activated Protein C and Thrombin, Journal of Biological Chemistry, vol.280, issue.13, pp.13122-13130, 2005. ,
DOI : 10.1074/jbc.M410381200
Mechanisms by Which Soluble Endothelial Cell Protein C Receptor Modulates Protein C and Activated Protein C Function, Journal of Biological Chemistry, vol.275, issue.8, pp.5447-52, 2000. ,
DOI : 10.1074/jbc.275.8.5447
The Soluble Endothelial Protein C Receptor Binds to Activated Neutrophils: Involvement of Proteinase-3 and CD11b/CD18, The Journal of Immunology, vol.165, issue.8, pp.4697-703, 2000. ,
DOI : 10.4049/jimmunol.165.8.4697
A 23bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR function, Thromb Haemost, vol.86, pp.945-953, 2001. ,
Bimodal distribution of soluble endothelial protein C receptor levels in healthy populations, Journal of Thrombosis and Haemostasis, vol.71, issue.4, pp.855-861, 2003. ,
DOI : 10.1016/S0140-6736(99)11180-2
A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis, Blood, vol.103, issue.4, pp.1311-1319, 2004. ,
DOI : 10.1182/blood-2003-07-2520
Contribution of polymorphisms in the endothelial protein C receptor gene to soluble endothelial protein C receptor, circulating activated protein C levels and thrombotic risk, Thrombosis and Haemostasis, vol.91, pp.905-916, 2004. ,
DOI : 10.1160/TH03-10-0657
Haplotypes of the EPCR gene, plasma sEPCR levels and the risk of deep venous thrombosis, Journal of Thrombosis and Haemostasis, vol.95, issue.8, pp.1305-1315, 2004. ,
DOI : 10.1016/S0140-6736(94)90286-0
The Ser219->Gly dimorphism of the endothelial protein C receptor contributes to the higher soluble protein levels observed in individuals with the A3 haplotype, Journal of Thrombosis and Haemostasis, vol.263, issue.1, pp.229-264, 2006. ,
DOI : 10.1182/blood-2004-03-1203
Alternative mRNA is favored by the A3 haplotype of the EPCR gene PROCR and generates a novel soluble form of EPCR in plasma, Blood, vol.111, issue.7, pp.3442-51, 2008. ,
DOI : 10.1182/blood-2007-08-104968
Soluble endothelial protein C receptor (sEPCR) levels and venous thromboembolism in carriers of two dysfunctional protein C variants, Thrombosis Research, vol.117, issue.5, pp.523-531, 2006. ,
DOI : 10.1016/j.thromres.2005.04.029
Haplotypes of the EPCR gene, prothrombin levels, and the risk of venous thrombosis in carriers of the prothrombin G20210A mutation, Haematologica, vol.93, issue.6, 2008. ,
DOI : 10.3324/haematol.12448
Influence of the 4600A/G and 4678G/C polymorphisms in the endothelial protein C receptor (EPCR) gene on the risk of venous thromboembolism in carriers of factor V Leiden, Thrombosis and Haemostasis, vol.94, pp.389-94, 2005. ,
DOI : 10.1160/TH05-02-0089
Shedding of endothelial protein C receptor contributes to vasculopathy and renal injury in lupus: In vivo and in vitro evidence1, Kidney International, vol.68, issue.1 ,
DOI : 10.1111/j.1523-1755.2005.00385.x
Dysfunction of Endothelial Protein C Activation in Severe Meningococcal Sepsis, New England Journal of Medicine, vol.345, issue.6, pp.408-424, 2001. ,
DOI : 10.1056/NEJM200108093450603
Expression and anticoagulant function of the endothelial cell protein C receptor (EPCR) in cancer cell lines, Thromb Haemost, vol.85, pp.356-61, 2001. ,
Activated protein C promotes breast cancer cell migration through interactions with EPCR and PAR-1, Experimental Cell Research, vol.313, issue.4, pp.677-87, 2007. ,
DOI : 10.1016/j.yexcr.2006.11.019
A truncated form of endothelial cell protein C receptor (EPCR) generated by alternative splicing is functionally similar to soluble EPCR, Haematologica, 2008. ,
Diffuse skin necrosis in a patient with an anti-endothelial cell protein C receptor autoantibody which blocks protein C activation, Journal of Thrombosis and Haemostasis, vol.73, issue.2, pp.413-418, 2005. ,
DOI : 10.1002/art.10187
High plasma levels of endothelial protein C receptor are associated with the risk of unexplained fetal death, Journal of Thrombosis and Haemostasis, vol.84, issue.2 ,
DOI : 10.1182/blood-2004-03-0793
Autoantibodies against the endothelial receptor of protein C are associated with acute myocardial infarction in young women, Journal of Thrombosis and Haemostasis, vol.167, issue.7, pp.1454-1462, 2005. ,
DOI : 10.1038/nm826