Skip to Main content Skip to Navigation
Journal articles

Association of non-HDL cholesterol with subclinical atherosclerosis in HIV-positive patients.: Non-HDL cholesterol and atherosclerosis in HIV patients.

Abstract : OBJECTIVES: To assess the relationship between non-classical cardiovascular (CV) risk factors including non-HDL cholesterol (non-HDL-C), apolipoprotein B, triglycerides to HDL ratio, LDL size, inflammation or oxidative stress parameters and carotid intima-media thickness (CIMT), in order to better identify prevention or therapeutic targets. In addition, we studied the relationship between metabolic syndrome (MS) and CIMT. METHODS: Cross-sectional study including 232 HIV-positive (HIV+) adults (80% treated by combined antiretroviral therapy) extracted from the ANRS CO3 Aquitaine Cohort. RESULTS: There was a significant association of higher non-HDL-C (p<0.01), apolipoprotein B (p<0.01) levels or TG/HDL ratio (p<0.05) with higher CIMT when compared the first vs fourth quartile, while there is no association between CIMT and LDL-C (p=0.09) or LDL size (p=0.55). In multivariate analysis, only the TG/HDL molar ratio > 1.5 tend toward significance (p=0.08). MS was observed in only 7.3% of patients with the NCEP-ATP III definition and 11.2% with the IDF criteria. Whatever the used definition, there was a significant association between MS presence and increased CIMT (p<0.05) in univariate and multivariate model. CONCLUSIONS: Non-HDL-C, TG/HDL ratio and apolipoprotein B levels, which are closely linked to lipid disorders associated to the MS, appear as stronger predictive markers than LDL-C for screening subclinical atherosclerosis in HIV+ populations. Achieving non-HDL-C target defined by the NCEP-ATP III guidelines appears of great importance to reduce CV complications in HIV+ patients.
Document type :
Journal articles
Complete list of metadatas

Cited literature [35 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00280760
Contributor : Evelyne Mouillet <>
Submitted on : Thursday, June 19, 2008 - 6:30:54 PM
Last modification on : Friday, May 15, 2020 - 12:22:04 PM
Long-term archiving on: : Friday, May 28, 2010 - 5:52:40 PM

Identifiers

Collections

Citation

Stéphanie Badiou, Rodolphe Thiébaut, Valérie Aurillac-Lavignolle, Francois Dabis, Frédéric Laporte, et al.. Association of non-HDL cholesterol with subclinical atherosclerosis in HIV-positive patients.: Non-HDL cholesterol and atherosclerosis in HIV patients.. Journal of Infection, WB Saunders, 2008, 57 (1), pp.47-54. ⟨10.1016/j.jinf.2008.05.007⟩. ⟨inserm-00280760⟩

Share

Metrics

Record views

245

Files downloads

599