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Developments towards tissueengineered, small-diameter arterial substitutes.

Abstract : This article reviews the present state of small-diameter vascular substitution, the mechanisms of graft failure and the ongoing matters of graft design, with particular attention to small-caliber grafts. Tissue engineering of blood vessels with the mechanical properties of native vessels and with the antithrombotic properties required is really a great challenge. Recent advances, however, indicate that the goal of providing a tissue-engineered vascular graft that will remain patent in vivo for substantial periods of time, is achievable. This review describes the specific requirements of the successful replacement artery from a biomaterial- and tissue-engineering perspective, as well as various approaches in vascular tissue engineering including cells and cell sources, scaffolds and their improvements as well as bioreactors and signaling.
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Contributor : Laurence Bordenave <>
Submitted on : Thursday, May 15, 2008 - 3:06:59 PM
Last modification on : Wednesday, November 29, 2017 - 2:54:22 PM
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Laurence Bordenave, Patrick Menu, Charles Baquey. Developments towards tissueengineered, small-diameter arterial substitutes.. Expert Review of Medical Devices, Expert Reviews, 2008, 5 (3), pp.337-347. ⟨10.1586/17434440.5.3.337⟩. ⟨inserm-00279868⟩



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