Autonoetic consciousness in Alzheimer's disease: neuropsychological and PET findings using an episodic learning and recognition task. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Neurobiol Aging Année : 2007

Autonoetic consciousness in Alzheimer's disease: neuropsychological and PET findings using an episodic learning and recognition task.

Résumé

OBJECTIVE: This study aims to map in patients with mild Alzheimer's disease (AD) the correlations between resting-state brain glucose utilization measured by FDG-PET and scores reflecting autonoetic consciousness in an episodic learning and recognition task. METHODS: Autonoetic consciousness, that gives a subject the conscious feeling to mentally travelling back in time to relive an event, was assessed using the Remember/Know (R/K) paradigm. RESULTS: AD patients provided less R responses (reflecting autonoetic consciousness) and more K ones (indicating the involvement of noetic consciousness) than healthy controls. Correct recognitions associated with a R response correlated with the metabolism of frontal areas bilaterally whereas those associated with a K response mainly correlated with the metabolism of left parahippocampal gyrus and lateral temporal cortex. CONCLUSIONS: These data show that recollection is impaired in AD and recognition is more based on a feeling of familiarity than in controls. In addition, the findings of our correlative approach indicate that the impairment of episodic memory is mainly subserved by the dysfunction of frontal areas and of the hippocampal region.
Fichier principal
Vignette du fichier
Rauchs_et_al_revised3.pdf (663.66 Ko) Télécharger le fichier
Loading...

Dates et versions

inserm-00277898 , version 1 (07-05-2008)

Identifiants

Citer

Géraldine Rauchs, Pascale Piolino, Florence Mézenge, Brigitte Landeau, Catherine Lalevée, et al.. Autonoetic consciousness in Alzheimer's disease: neuropsychological and PET findings using an episodic learning and recognition task.. Neurobiol Aging, 2007, 28 (9), pp.1410-20. ⟨10.1016/j.neurobiolaging.2006.06.005⟩. ⟨inserm-00277898⟩
175 Consultations
560 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More