Neural correlates of age-related verbal episodic memory decline: a PET study with combined subtraction/correlation analysis. - Archive ouverte HAL Access content directly
Journal Articles Neurobiol Aging Year : 2007

Neural correlates of age-related verbal episodic memory decline: a PET study with combined subtraction/correlation analysis.

(1) , (2) , (2) , (3)
1
2
3

Abstract

Using PET, we have determined the neural substrates of age-related verbal episodic memory decline. Twelve young and twelve older healthy volunteers (mean age; 22 and 59 years, respectively) were scanned while performing encoding and retrieval tasks. Retrieval performance was lower in old than in young subjects. The PET data were analyzed using a combined subtraction/correlation approach. Classic subtraction disclosed prefrontal rCBF increases common to both groups, distributed bilaterally during encoding and exclusively right-sided during retrieval, without between-group differences. The correlation analysis between PET activity during encoding and subsequent retrieval performance revealed significant correlations for the left hippocampal region in both groups, but for the right inferior frontal gyrus in the older subjects only. Thus, lower performance in older subjects during an episodic retrieval task may reflect a combination of (i) subtle encoding dysfunction, evidenced by more widespread activity-performance correlations and (ii) less efficient retrieval, as evidenced by unaltered activation pattern (as revealed by the classic subtraction method) despite reduced performance. These exploratory findings suggest the aged brain may be unable to compensate for reduced efficiency of right prefrontal cortex by additional left frontal activation.
Fichier principal
Vignette du fichier
Manuscript2.pdf (175.44 Ko) Télécharger le fichier
Vignette du fichier
Bernard-Figures.doc (191 Ko) Télécharger le fichier
Format : Other
Loading...

Dates and versions

inserm-00277803 , version 1 (07-05-2008)

Identifiers

Cite

Frédéric A. Bernard, Béatrice Desgranges, Francis Eustache, Jean-Claude Baron. Neural correlates of age-related verbal episodic memory decline: a PET study with combined subtraction/correlation analysis.. Neurobiol Aging, 2007, 28 (10), pp.1568-76. ⟨10.1016/j.neurobiolaging.2006.07.004⟩. ⟨inserm-00277803⟩
86 View
212 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More