J. Alao, The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention, Molecular Cancer, vol.6, issue.1, p.24, 2007.
DOI : 10.1186/1476-4598-6-24

D. An, G. Kewalramani, J. Chan, D. Qi, S. Ghosh et al., Metformin influences cardiomyocyte cell death by pathways that are dependent and independent of caspase-3, Diabetologia, vol.191, issue.Suppl 1, pp.2174-2184, 2006.
DOI : 10.1007/s00125-006-0338-9

M. Aouadi, K. Laurent, M. Prot, L. Marchand-brustel, Y. Binetruy et al., Inhibition of p38MAPK Increases Adipogenesis From Embryonic to Adult Stages, Diabetes, vol.55, issue.2, pp.281-289, 2006.
DOI : 10.2337/diabetes.55.02.06.db05-0963

F. Bost, R. Mckay, M. Bost, O. Potapova, N. Dean et al., The Jun Kinase 2 Isoform Is Preferentially Required for Epidermal Growth Factor-Induced Transformation of Human A549 Lung Carcinoma Cells, Molecular and Cellular Biology, vol.19, issue.3, pp.1938-1949, 1999.
DOI : 10.1128/MCB.19.3.1938

I. Campbell, Metformin and the sulphonylureas: the comparative risk, Horm Metab Res, vol.15, pp.105-111, 1985.

Y. Chen, L. Martinez, M. Lacava, L. Coghlan, and C. Conti, Increased cell growth and tumorigenicity in human prostate LNCaP cells by overexpression to cyclin D1, Oncogene, vol.16, issue.15, pp.1913-1920, 1998.
DOI : 10.1038/sj.onc.1201719

S. Collins, J. Reoma, D. Gamm, and M. Uhler, LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo, Biochemical Journal, vol.345, issue.3, pp.673-680, 2000.
DOI : 10.1042/bj3450673

Y. Dagon, Y. Avraham, and E. Berry, AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2?? in adipocytes, Biochemical and Biophysical Research Communications, vol.340, issue.1, pp.43-47, 2006.
DOI : 10.1016/j.bbrc.2005.11.159

J. Davis, K. Wojno, S. Daignault, M. Hofer, R. Kuefer et al., Elevated E2F1 Inhibits Transcription of the Androgen Receptor in Metastatic Hormone-Resistant Prostate Cancer, Cancer Research, vol.66, issue.24, pp.11897-11906, 2006.
DOI : 10.1158/0008-5472.CAN-06-2497

S. Denmeade and J. Isaacs, Development of prostate cancer treatment: The good news, The Prostate, vol.59, issue.3, pp.211-224, 2004.
DOI : 10.1002/pros.10360

D. Detaille, B. Guigas, C. Chauvin, C. Batandier, E. Fontaine et al., Metformin Prevents High-Glucose-Induced Endothelial Cell Death Through a Mitochondrial Permeability Transition-Dependent Process, Diabetes, vol.54, issue.7, pp.2179-2187, 2005.
DOI : 10.2337/diabetes.54.7.2179

URL : https://hal.archives-ouvertes.fr/inserm-00388755

J. Diehl, M. Cheng, M. Roussel, and C. Sherr, Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization, Genes & Development, vol.12, issue.22, pp.3499-3511, 1998.
DOI : 10.1101/gad.12.22.3499

M. Drobnjak, I. Osman, H. Scher, M. Fazzari, and C. Cordon-cardo, Overexpression of cyclin D1 is associated with metastatic prostate cancer to bone, Clin Cancer Res, vol.6, pp.1891-1895, 2000.

M. El-mir, V. Nogueira, E. Fontaine, N. Averet, M. Rigoulet et al., Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I, Journal of Biological Chemistry, vol.275, issue.1, pp.223-228, 2000.
DOI : 10.1074/jbc.275.1.223

URL : https://hal.archives-ouvertes.fr/inserm-00390049

S. Erlich, P. Tal-or, R. Liebling, R. Blum, D. Karunagaran et al., Ras inhibition results in growth arrest and death of androgen-dependent and androgen-independent prostate cancer cells, Biochemical Pharmacology, vol.72, issue.4, pp.427-436, 2006.
DOI : 10.1016/j.bcp.2006.05.007

J. Evans, L. Donnelly, A. Emslie-smith, D. Alessi, and A. Morris, Metformin and reduced risk of cancer in diabetic patients, BMJ, vol.330, issue.7503, pp.1304-1305, 2005.
DOI : 10.1136/bmj.38415.708634.F7

B. Guigas, L. Bertrand, N. Taleux, M. Foretz, N. Wiernsperger et al., 5-Aminoimidazole-4-Carboxamide-1-??-D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase-Independent Effect on Glucokinase Translocation, Diabetes, vol.55, issue.4, pp.865-874, 2006.
DOI : 10.2337/diabetes.55.04.06.db05-1178

E. Han, J. Lim, N. Arber, M. Rubin, W. Xing et al., Cyclin D1 expression in human prostate carcinoma cell lines and primary tumors, The Prostate, vol.91, issue.2, pp.95-101, 1998.
DOI : 10.1002/(SICI)1097-0045(19980501)35:2<95::AID-PROS2>3.0.CO;2-F

D. Hardie, Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status, Endocrinology, vol.144, issue.12, pp.5179-5183, 2003.
DOI : 10.1210/en.2003-0982

S. Hawley, A. Gadalla, G. Olsen, and D. Hardie, The Antidiabetic Drug Metformin Activates the AMP-Activated Protein Kinase Cascade via an Adenine Nucleotide-Independent Mechanism, Diabetes, vol.51, issue.8, pp.2420-2425, 2002.
DOI : 10.2337/diabetes.51.8.2420

M. Herrant, A. Jacquel, S. Marchetti, N. Belhacene, P. Colosetti et al., Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis, Oncogene, vol.23, issue.47, pp.7863-7873, 2004.
DOI : 10.1038/sj.onc.1208069

T. Hunter, Oncoprotein Networks, Cell, vol.88, issue.3, pp.333-346, 1997.
DOI : 10.1016/S0092-8674(00)81872-3

URL : http://doi.org/10.1016/s0092-8674(00)81872-3

L. Ibanez, K. Ong, C. Valls, M. Marcos, D. Dunger et al., Metformin Treatment to Prevent Early Puberty in Girls with Precocious Pubarche, The Journal of Clinical Endocrinology & Metabolism, vol.91, issue.8, pp.2888-2891, 2006.
DOI : 10.1210/jc.2006-0336

B. Kahn, T. Alquier, D. Carling, and D. Hardie, AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism, Cell Metabolism, vol.1, issue.1, pp.15-25, 2005.
DOI : 10.1016/j.cmet.2004.12.003

S. Libertini, C. Tepper, G. M. Lu, Y. Asmuth, D. Mudryj et al., E2F1 expression in LNCaP prostate cancer cells deregulates androgen dependent growth, suppresses differentiation, and enhances apoptosis, The Prostate, vol.1, issue.1, pp.70-81, 2006.
DOI : 10.1002/pros.20314

J. Lord, I. Flight, and R. Norman, Metformin in polycystic ovary syndrome: systematic review and meta-analysis, BMJ, vol.327, issue.7421, pp.951-953, 2003.
DOI : 10.1136/bmj.327.7421.951

A. Loubat, N. Rochet, L. Turchi, R. Rezzonico, D. Far et al., Evidence for a p23 caspase-cleaved form of p27[KIP1] involved in G1 growth arrest, Oncogene, vol.18, issue.22, pp.3324-3333, 1999.
DOI : 10.1038/sj.onc.1202668

G. Marchesini, M. Brizi, G. Bianchi, S. Tomassetti, M. Zoli et al., Metformin in non-alcoholic steatohepatitis, The Lancet, vol.358, issue.9285, pp.893-894, 2001.
DOI : 10.1016/S0140-6736(01)06042-1

H. Matsushime, D. Quelle, S. Shurtleff, M. Shibuya, C. Sherr et al., D-type cyclin-dependent kinase activity in mammalian cells., Molecular and Cellular Biology, vol.14, issue.3, pp.2066-2076, 1994.
DOI : 10.1128/MCB.14.3.2066

C. Park, I. Lee, and W. Kang, Influence of small interfering RNA corresponding to ets homologous factor on senescence-associated modulation of prostate carcinogenesis, Molecular Cancer Therapeutics, vol.5, issue.12, pp.3191-3196, 2006.
DOI : 10.1158/1535-7163.MCT-06-0570

J. Perry, M. Grossmann, and D. Tindall, Epidermal growth factor induces cyclin D1 in a human prostate cancer cell line, The Prostate, vol.9, issue.2, pp.117-124, 1998.
DOI : 10.1002/(SICI)1097-0045(19980501)35:2<117::AID-PROS5>3.0.CO;2-G

S. Plymate, M. Tennant, R. Birnbaum, J. Thrasher, G. Chatta et al., The effect on the insulin-like growth factor system in human prostate epithelial cells of immortalization and transformation by simian virus-40 T antigen, J Clin Endocrinol Metab, vol.81, pp.3709-3716, 1996.

N. Ruderman, H. Park, V. Kaushik, D. Dean, S. Constant et al., AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise, Acta Physiologica Scandinavica, vol.258, issue.4, pp.435-442, 2003.
DOI : 10.1042/0264-6021:3400213

M. Schneider, H. Matsuzaki, J. Haorah, A. Ulrich, J. Standop et al., Prevention of pancreatic cancer induction in hamsters by metformin, Gastroenterology, vol.120, issue.5, pp.1263-1270, 2001.
DOI : 10.1053/gast.2001.23258

S. Sharan, M. Morimatsu, U. Albrecht, D. Lim, E. Regel et al., Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2, Nature, vol.386, issue.6627, pp.804-810, 1997.
DOI : 10.1038/386804a0

C. Sherr and J. Roberts, Inhibitors of mammalian G1 cyclin-dependent kinases., Genes & Development, vol.9, issue.10, pp.1149-1163, 1995.
DOI : 10.1101/gad.9.10.1149

R. Weinberg, The retinoblastoma protein and cell cycle control, Cell, vol.81, issue.3, pp.323-330, 1995.
DOI : 10.1016/0092-8674(95)90385-2

Y. Zhang, R. Howell, D. Alfonso, Y. J. Kong, L. Wittig et al., IFI16 inhibits tumorigenicity and cell proliferation of bone and cartilage tumor cells, Frontiers in Bioscience, vol.12, issue.12, pp.4855-4863, 2007.
DOI : 10.2741/2433

G. Zhou, R. Myers, Y. Li, Y. Chen, X. Shen et al., Role of AMP-activated protein kinase in mechanism of metformin action, Journal of Clinical Investigation, vol.108, issue.8, pp.1167-1174, 2001.
DOI : 10.1172/JCI13505