E. Cranenburg, L. Schurgers, and C. Vermeer, Vitamin K: The coagulation vitamin that became omnipotent, Thrombosis and Haemostasis, vol.98, pp.120-125, 2007.
DOI : 10.1160/TH07-04-0266

G. Luo, P. Ducy, and M. Mckee, Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein, Nature, vol.386, issue.6620, pp.78-81, 1997.
DOI : 10.1038/386078a0

S. Herrmann, C. Whatling, and E. Brand, Polymorphisms of the Human Matrix Gla Protein (MGP) Gene, Vascular Calcification, and Myocardial Infarction, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.20, issue.11, pp.2386-2393, 2000.
DOI : 10.1161/01.ATV.20.11.2386

Y. Wang, Y. Zhen, and Y. Shi, Vitamin K Epoxide Reductase: A Protein Involved in Angiogenesis, Molecular Cancer Research, vol.3, issue.6, pp.317-323, 2005.
DOI : 10.1158/1541-7786.MCR-04-0221

S. Rost, A. Fregin, and V. Ivaskevicius, Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2, Nature, vol.427, issue.6974, pp.537-541, 2004.
DOI : 10.1038/nature02214

L. Bodin, M. Horellou, and C. Flaujac, A vitamin K epoxide reductase complex subunit-1 (VKORC1) mutation in a patient with vitamin K antagonist resistance, Journal of Thrombosis and Haemostasis, vol.27, issue.7, pp.1533-1535, 2005.
DOI : 10.1038/nature02214

M. Rieder, A. Reiner, and B. Gage, Haplotypes on Transcriptional Regulation and Warfarin Dose, New England Journal of Medicine, vol.352, issue.22, pp.2285-2293, 2005.
DOI : 10.1056/NEJMoa044503

C. Geisen, M. Watzka, and K. Sittinger, VKORC1 haplotypes and their impact on the inter-individual and inter-ethnical variability of oral anticoagulation, Thromb Haemost, vol.94, pp.773-779, 2005.

L. Bodin, C. Verstuyft, and D. Tregouet, Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity, Blood, vol.106, issue.1, pp.135-140, 2005.
DOI : 10.1182/blood-2005-01-0341

J. Oldenburg, C. Bevans, and A. Fregin, Current pharmacogenetic developments in oral anticoagulation therapy: The influence of variant VKORC1 and CYP2C9 alleles, Thrombosis and Haemostasis, vol.98, pp.570-578, 2007.
DOI : 10.1160/TH07-07-0454

V. Siguret, Antivitamines K et??pharmacog??n??tique: vers une??meilleure compr??hension de??la??variabilit?? individuelle de??l'effet dose???r??ponse, Pathologie Biologie, vol.55, issue.6, pp.295-298, 2007.
DOI : 10.1016/j.patbio.2007.04.001

M. Loriot and P. Beaune, La vitamine K ??poxyde r??ductase: du??sang neuf??dans??les??traitements anticoagulants oraux, La Revue de M??decine Interne, vol.27, issue.12, pp.979-982, 2006.
DOI : 10.1016/j.revmed.2006.09.004

Y. Wang, W. Zhang, and Y. Zhang, VKORC1 Haplotypes Are Associated With Arterial Vascular Diseases (Stroke, Coronary Heart Disease, and Aortic Dissection), Circulation, vol.113, issue.12, pp.1615-1621, 2006.
DOI : 10.1161/CIRCULATIONAHA.105.580167

K. Lacut, C. Larramendy-gozalo, L. Gal, and G. , Vitamin K epoxide reductase genetic polymorphism is associated with venous thromboembolism: results from the EDITH Study, Journal of Thrombosis and Haemostasis, vol.128, issue.10, pp.2020-2024, 2007.
DOI : 10.1532/IJH97.06082

URL : https://hal.archives-ouvertes.fr/hal-00688300

M. Watzka, A. Nebel, and N. Mokhtari, Functional promoter polymorphism in the VKORC1 gene is no major genetic determinant for coronary heart disease in Northern Germans, Thrombosis and Haemostasis, vol.97, pp.998-1002, 2007.
DOI : 10.1160/TH06-11-0643

L. Hindorff, S. Heckbert, and N. Smith, Common VKORC1 variants are not associated with arterial or venous thrombosis, Journal of Thrombosis and Haemostasis, vol.5, issue.10, pp.2025-2027, 2007.
DOI : 10.1038/sj.clpt.6100144

J. Reny, M. Alhenc-gelas, and P. Fontana, The factor II G20210A gene polymorphism, but not factor V Arg506Gln, is associated with peripheral arterial disease: results of a case-control study, Journal of Thrombosis and Haemostasis, vol.90, issue.8, pp.1334-1340, 2004.
DOI : 10.1046/j.1538-7836.2003.00008.x

P. Fontana, P. Gaussem, and M. Aiach, P2Y12 H2 Haplotype Is Associated With Peripheral Arterial Disease: A Case-Control Study, Circulation, vol.108, issue.24, pp.2971-2973, 2003.
DOI : 10.1161/01.CIR.0000106904.80795.35