F. R. Maxfield and D. Wustner, Intracellular cholesterol transport, Journal of Clinical Investigation, vol.110, issue.7, pp.891-898, 2002.
DOI : 10.1172/JCI16500DS1

S. Vainio and E. Ikonen, Macrophage cholesterol transport: a critical player in foam cell formation, Annals of Medicine, vol.99, issue.10, pp.146-155, 2003.
DOI : 10.1126/science.290.5497.1771

R. E. Soccio and J. L. Leslow, Intracellular Cholesterol Transport, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.24, issue.7, pp.1150-1160, 2004.
DOI : 10.1161/01.ATV.0000131264.66417.d5

H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov et al., A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis : A Report From the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association, A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, pp.1355-1374, 1995.
DOI : 10.1161/01.CIR.92.5.1355

I. Tabas, Consequences of cellular cholesterol accumulation: basic concepts and physiological implications, Journal of Clinical Investigation, vol.110, issue.7, pp.905-911, 2002.
DOI : 10.1172/JCI0216452

J. Gruenberg, The endocytic pathway: a mosaic of domains, Nature Reviews Molecular Cell Biology, vol.108, issue.10, pp.721-730, 2001.
DOI : 10.1038/35096054

T. Kobayashi, A. Yamaji-hasegawa, and E. Kiyokawa, Lipid domains in the endocytic pathway, Seminars in Cell & Developmental Biology, vol.12, issue.2, pp.173-182, 2001.
DOI : 10.1006/scdb.2000.0234

T. Kobayashi, M. H. Beuchat, M. Lindsay, S. Frias, R. D. Palmiter et al., Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport, Nat. Cell Biol, vol.1, pp.113-118, 1999.

S. Mukherjee and F. R. Maxfield, Lipid and cholesterol trafficking in NPC, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol.1685, issue.1-3, pp.28-37, 2004.
DOI : 10.1016/j.bbalip.2004.08.009

T. Kobayashi, E. Stang, K. S. Fang, P. De-moerloose, R. G. Parton et al., A lipid associated with the antiphospholipid syndrome regulates endosome structure and function, Nature, vol.89, issue.6672, pp.193-197, 1998.
DOI : 10.1038/32440

T. Kobayashi, F. Gu, and J. Gruenberg, Lipids, lipid domains and lipid???protein interactions in endocytic membrane traffic, Seminars in Cell & Developmental Biology, vol.9, issue.5, pp.517-526, 1998.
DOI : 10.1006/scdb.1998.0257

T. Kobayashi, K. Startchev, A. J. Whitney, and J. Gruenberg, Localization of Lysobisphosphatidic Acid-Rich Membrane Domains in Late Endosomes, Biological Chemistry, vol.382, issue.3, pp.483-485, 2001.
DOI : 10.1515/BC.2001.059

T. Kobayashi, M. H. Beuchat, J. Chevallier, A. Makino, N. Mayran et al., Separation and Characterization of Late Endosomal Membrane Domains, Journal of Biological Chemistry, vol.277, issue.35, pp.32157-32164, 2002.
DOI : 10.1074/jbc.M202838200

L. Blanc, I. , P. P. Luyet, V. Pons, C. Ferguson et al., Endosome-to-cytosol transport of viral nucleocapsids, Nature Cell Biology, vol.103, issue.7, pp.653-664, 2005.
DOI : 10.1034/j.1600-0854.2000.010607.x

URL : https://hal.archives-ouvertes.fr/inserm-00381829

B. Galve-de-rochemonteix, T. Kobayashi, C. Rosnoblet, M. Lindsay, R. G. Parton et al., Interaction of Anti-Phospholipid Antibodies With Late Endosomes of Human Endothelial Cells, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.20, issue.2, pp.563-574, 2000.
DOI : 10.1161/01.ATV.20.2.563

C. Alessandri, M. Bombardieri, L. Di-prospero, P. Conigliaro, F. Conti et al., Anti-lysobisphosphatidic acid antibodies in patients with antiphospholipid syndrome and systemic lupus erythematosus, Clinical and Experimental Immunology, vol.6, issue.1, pp.173-180, 2005.
DOI : 10.1038/sj.cdd.4401457

G. Valesini and C. Alessandri, New Facet of Antiphospholipid Antibodies, Annals of the New York Academy of Sciences, vol.12, issue.1, pp.487-497, 2005.
DOI : 10.1196/annals.1361.089

G. Wilkening, T. Linke, and K. Sandhoff, Lysosomal Degradation on Vesicular Membrane Surfaces: ENHANCED GLUCOSYLCERAMIDE DEGRADATION BY LYSOSOMAL ANIONIC LIPIDS AND ACTIVATORS, Journal of Biological Chemistry, vol.273, issue.46, pp.30271-30278, 1998.
DOI : 10.1074/jbc.273.46.30271

G. Wilkening, T. Linke, G. Uhlhorn-dierks, and K. Sandhoff, Degradation of Membrane-bound Ganglioside GM1: STIMULATION BY BIS(MONOACYLGLYCERO)PHOSPHATE AND THE ACTIVATOR PROTEINS SAP-B AND GM2-AP, Journal of Biological Chemistry, vol.275, issue.46, pp.35814-35819, 2000.
DOI : 10.1074/jbc.M006568200

T. Linke, G. Wilkening, F. Sadeghlar, H. Mozcall, K. Bernardo et al., Interfacial Regulation of Acid Ceramidase Activity: STIMULATION OF CERAMIDE DEGRADATION BY LYSOSOMAL LIPIDS AND SPHINGOLIPID ACTIVATOR PROTEINS, Journal of Biological Chemistry, vol.276, issue.8, pp.5760-5768, 2001.
DOI : 10.1074/jbc.M006846200

N. Werth, C. G. Schuette, G. Wilkening, T. Lemm, and K. Sandhoff, Degradation of Membrane-bound Ganglioside GM2 by beta -Hexosaminidase A. STIMULATION BY GM2 ACTIVATOR PROTEIN AND LYSOSOMAL LIPIDS, Journal of Biological Chemistry, vol.276, issue.16, pp.12685-12690, 2001.
DOI : 10.1074/jbc.M007970200

H. Matsuo, J. Chevallier, N. Mayran, I. L. Blanc, C. Ferguson et al., Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization, Science, vol.303, issue.5657, pp.531-534, 2004.
DOI : 10.1126/science.1092425

N. Besson, F. Hullin-matsuda, A. Makino, M. Murate, M. Lagarde et al., Selective incorporation of docosahexaenoic acid into lysobisphosphatidic acid in cultured THP-1 macrophages, Lipids, vol.36, issue.Suppl., pp.189-196, 2006.
DOI : 10.1007/s11745-006-5087-5

S. K. Basu, J. L. Goldstein, G. W. Anderson, and M. S. Brown, Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts., Proc. Natl. Acad. Sci. USA, pp.3178-3182, 1976.
DOI : 10.1073/pnas.73.9.3178

I. Maor and M. Aviram, Oxidized low density lipoprotein leads to macrophage accumulation of unesterified cholesterol as a result of lysosomal trapping of the lipoprotein hydrolyzed cholesteryl ester, J. Lipid Res, vol.35, pp.803-819, 1994.

P. G. Yancey and W. G. Jerome, Lysosomal cholesterol derived from mildly oxidized low density lipoprotein is resistant to efflux, J. Lipid Res, vol.42, pp.317-327, 2001.

L. Kritharides, A. Christian, G. Stoudt, D. Morel, and G. H. Rothblat, 3.P.167 Cholesterol metabolism and efflux in human THP-1 macrophages, Atherosclerosis, vol.134, issue.1-2, pp.1589-1599, 1998.
DOI : 10.1016/S0021-9150(97)89240-4

E. G. Bligh and W. J. Dyer, A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION, Canadian Journal of Biochemistry and Physiology, vol.37, issue.8, pp.911-917, 1959.
DOI : 10.1139/o59-099

J. F. Pageaux, S. Bechoua, G. Bonnot, J. M. Fayard, H. Cohen et al., Biogenesis and Metabolic Fate of Docosahexaenoic and Arachidonic Acids in Rat Uterine Stromal Cells in Culture, Archives of Biochemistry and Biophysics, vol.327, issue.1, pp.142-150, 1996.
DOI : 10.1006/abbi.1996.0102

J. P. Slotte, G. Hedstrom, S. Rannstrom, and S. Ekman, Effects of sphingomyelin degradation on cell cholesterol oxidizability and steady-state distribution between the cell surface and the cell interior, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.985, issue.1, pp.90-96, 1989.
DOI : 10.1016/0005-2736(89)90108-9

K. W. Underwood, B. Andemariam, G. L. Mcwilliams, and L. Liscum, Quantitative analysis of hydrophobic amine inhibition of intracellular cholesterol transport, J. Lipid Res, vol.37, pp.1556-1568, 1996.

I. J. White, L. M. Bailey, M. R. Aghakhani, S. E. Moss, and C. E. Futter, EGF stimulates annexin 1-dependent inward vesiculation in a multivesicular endosome subpopulation, The EMBO Journal, vol.278, issue.1, pp.1-12, 2006.
DOI : 10.1038/sj.emboj.7600759

L. Liscum and J. R. Faust, The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-beta-[2-(diethylamino)ethoxy] androst-5-en-17-one, J. Biol. Chem, vol.264, pp.11796-11806, 1989.

H. Yang, D. Cromley, H. Wang, J. T. Billheimer, and S. L. Sturley, Functional Expression of a cDNA to Human Acyl-coenzyme A:Cholesterol Acyltransferase in Yeast: SPECIES-DEPENDENT SUBSTRATE SPECIFICITY AND INHIBITOR SENSITIVITY, Journal of Biological Chemistry, vol.272, issue.7, pp.3980-3985, 1997.
DOI : 10.1074/jbc.272.7.3980

Y. Wang, A. B. Castoreno, W. Stockinger, and A. Nohturfft, Modulation of Endosomal Cholesteryl Ester Metabolism by Membrane Cholesterol, Journal of Biological Chemistry, vol.280, issue.12, pp.11876-11886, 2005.
DOI : 10.1074/jbc.M414676200

E. B. Neufeld, A. M. Cooney, J. Pitha, E. A. Dawidowicz, N. K. Dwyer et al., Intracellular trafficking of cholesterol monitored with a cyclodextrin, J. Biol. Chem, vol.271, pp.21604-21613, 1996.

K. W. Underwood, N. L. Jacobs, A. Howley, and L. Liscum, Evidence for a Cholesterol Transport Pathway from Lysosomes to Endoplasmic Reticulum That Is Independent of the Plasma Membrane, Journal of Biological Chemistry, vol.273, issue.7, pp.4266-4274, 1998.
DOI : 10.1074/jbc.273.7.4266

N. K. Dahl, K. L. Reed, M. A. Daunais, J. R. Faust, and L. Liscum, Isolation and characterization of Chinese hamster ovary cells defective in the intracellular metabolism of low density lipoproteinderived cholesterol, J. Biol. Chem, vol.267, pp.4889-4896, 1992.

. Agler, Identification of a pharmaceutical compound that partially corrects the Niemann-Pick C phenotype in cultured cells, J. Lipid Res, vol.43, pp.1708-1717, 2002.

Y. Lange and B. V. Ramos, Analysis of the distribution of cholesterol in the intact cell, J. Biol. Chem, vol.258, pp.15130-15134, 1983.

S. Sugii, P. C. Reid, N. Ohgami, H. Du, and T. Chang, Distinct Endosomal Compartments in Early Trafficking of Low Density Lipoprotein-derived Cholesterol, Journal of Biological Chemistry, vol.278, issue.29, pp.27180-27189, 2003.
DOI : 10.1074/jbc.M300542200

B. J. Reaves, P. E. Row, N. A. Bright, J. P. Luzio, and H. W. Davidson, Loss of cation-independent mannose 6-phosphate receptor expression promotes the accumulation of lysobisphosphatidic acid in multilamellar bodies, J. Cell Sci, vol.113, pp.4099-4108, 2000.

C. Lebrand, M. Corti, H. Goodson, P. Cosson, V. Cavalli et al., Late endosome motility depends on lipids via the small GTPase Rab7, The EMBO Journal, vol.98, issue.6, pp.1289-1300, 2002.
DOI : 10.1093/emboj/21.6.1289

B. Feng, P. M. Yao, Y. Li, C. M. Devlin, D. Zhang et al., The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages, Nature Cell Biology, vol.5, issue.9, pp.781-792, 2003.
DOI : 10.1038/ncb1035

Y. Shiratori, A. K. Okwu, and I. Tabas, Free cholesterol loading of macrophages stimulates phosphatidylcholine biosynthesis and up-regulation of CTP:phosphocholine cytidylyltransferase, J. Biol. Chem, vol.269, pp.11337-11348, 1994.

P. M. Yao and I. Tabas, Free Cholesterol Loading of Macrophages Induces Apoptosis Involving the Fas Pathway, Journal of Biological Chemistry, vol.275, issue.31, pp.23807-23813, 2000.
DOI : 10.1074/jbc.M002087200

P. M. Yao and I. Tabas, Free Cholesterol Loading of Macrophages Is Associated with Widespread Mitochondrial Dysfunction and Activation of the Mitochondrial Apoptosis Pathway, Journal of Biological Chemistry, vol.276, issue.45, pp.42468-42476, 2001.
DOI : 10.1074/jbc.M101419200

K. Gaus, L. Kritharides, G. Schmitz, A. Boettcher, W. Drobnik et al., Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages, The FASEB Journal, vol.18, pp.574-576, 2004.
DOI : 10.1096/fj.03-0486fje

A. J. Mendez, G. Lin, D. P. Wade, R. M. Lawn, and J. F. Oram, Membrane Lipid Domains Distinct from Cholesterol/Sphingomyelin-Rich Rafts Are Involved in the ABCA1-mediated Lipid Secretory Pathway, Journal of Biological Chemistry, vol.276, issue.5, pp.3158-3166, 2001.
DOI : 10.1074/jbc.M007717200

W. Drobnik, H. Borsukova, A. Bottcher, A. Pfeiffer, G. Liebisch et al., Apo AI/ABCA1-Dependent and HDL3-Mediated Lipid Efflux from Compositionally Distinct Cholesterol-Based Microdomains, Traffic, vol.94, issue.4, pp.268-278, 2002.
DOI : 10.1034/j.1600-0854.2002.030404.x

N. Wang, D. Lan, W. Chen, F. Matsuura, and A. R. , ATPbinding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins, Proc. Natl. Acad. Sci. USA, pp.9774-9779, 2004.
DOI : 10.1073/pnas.0403506101

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC470750

A. M. Vaughan and J. F. Oram, ABCG1 Redistributes Cell Cholesterol to Domains Removable by High Density Lipoprotein but Not by Lipid-depleted Apolipoproteins, Journal of Biological Chemistry, vol.280, issue.34, pp.30150-30157, 2005.
DOI : 10.1074/jbc.M505368200