Abnormal digital neurovascular response to local heating in systemic sclerosis. - Archive ouverte HAL Access content directly
Journal Articles Rheumatology Year : 2008

Abnormal digital neurovascular response to local heating in systemic sclerosis.

(1, 2) , (3) , (4) , (1, 2)
1
2
3
4

Abstract

OBJECTIVES: To investigate neurovascular dysfunction using the axon reflex-dependent hyperaemia (initial peak of skin local heating response) in fingers of patients with SSc or primary RP. METHODS: Ten healthy subjects were initially enrolled to compare axon reflex-dependent thermal hyperaemia between the finger and forearm cutaneous circulations. Then, 10 patients with primary RP and 16 patients with SSc participated in a similar protocol focusing on the finger circulation only. Lidocaine/prilocaine cream was applied for 1 h to produce local blockade of cutaneous sensory nerves. After lidocaine/prilocaine pre-treatment, laser Doppler probes were heated from skin temperature to 42 degrees C for 30 min, and 44 degrees C for 5 min to achieve maximal skin blood flow. Data were expressed as a percentage of maximal cutaneous vascular conductance. RESULTS: In healthy volunteers, we observed a significantly higher initial peak on the finger compared with the forearm, with both responses blunted following topical anaesthesia. In primary RP patients, we observed a decreased initial peak following lidocaine/prilocaine pre-treatment in the finger circulation [96.7% (33.4) vs 75.9% (29.5) with anaesthesia, P = 0.02]. In contrast, pre-treatment did not alter the initial peak in patients with SSc. A minute-by-minute analysis showed no delay of the initial peak. CONCLUSIONS: We show an abnormal digital neurovascular response to local heating in SSc. Thermal hyperaemia could be monitored as a clinical test for neurovascular function in SSc. Further studies are required to test whether the abnormal digital neurovascular response correlates to the degree of peripheral vascular involvement.
Fichier principal
Vignette du fichier
Proof_for_peer_review_Rheumatology_review1.pdf (592.69 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-00273825 , version 1 (16-04-2008)

Identifiers

Cite

Matthieu Roustit, Grant H. Simmons, Patrick H. Carpentier, Jean-Luc Cracowski. Abnormal digital neurovascular response to local heating in systemic sclerosis.. Rheumatology, 2008, 47 (6), pp.860-4. ⟨10.1093/rheumatology/ken065⟩. ⟨inserm-00273825⟩

Collections

INSERM UGA
103 View
147 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More