Hormonal treatment, mild cognitive impairment and Alzheimer's disease. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue International Psychogeriatrics Année : 2008

Hormonal treatment, mild cognitive impairment and Alzheimer's disease.

Résumé

A plethora of in vitro and in vivo studies have supported the neuroprotective role of estrogens and their impact on the neurotransmitter systems implicated in cognition. Recent hormonal replacement therapy (HRT) trials in non-demented postmenopausal women suggest a temporary positive effect (notably on verbal memory), and four meta-analyses converge to suggest a possible protective effect in relation to Alzheimer's disease (reducing risk by 29 to 44%). However, data from the only large randomized controlled trial published to date, the Women's Health Initiative Memory Study, did not confirm these observations and have even suggested an increase in dementia risk for women using HRT compared to controls. Apart from methodological differences, one key shortcoming of this trial has probably been the focus on late-onset (postmenopausal) hormonal changes, i.e. at a time when the neurodegenerative process has already begun and without taking into account individual lifetime exposure to hormone variability. Multifactorial models based on an exhaustive view of all hormonal events throughout the reproductive life (rather than on a specific exposure to a given steroid) together with other risk factors (notably genetic risk factors related to estrogen receptor polymorphisms) should be explored to clarify the role of hormonal risk factors, or protective factors for cognitive dysfunction and dementia.
Fichier principal
Vignette du fichier
RyanIntPsychogeriatrics.pdf (355 Ko) Télécharger le fichier
inserm-00271473_edited.pdf (221.08 Ko) Télécharger le fichier
Loading...

Dates et versions

inserm-00271473 , version 1 (09-04-2008)

Identifiants

Citer

Joanne Ryan, Jacqueline Scali, Isabelle Carriere, Karen A. Ritchie, Marie-Laure Ancelin. Hormonal treatment, mild cognitive impairment and Alzheimer's disease.. International Psychogeriatrics, 2008, 20 (1), pp.47-56. ⟨10.1017/S1041610207006485⟩. ⟨inserm-00271473⟩
62 Consultations
569 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More