Skip to Main content Skip to Navigation
Journal articles

Down syndrome time-clustering in January 1987 in Belarus: link with the Chernobyl accident?: Down syndrome after Chernobyl

Abstract : The Chernobyl accident (April 26, 1986) exposed a large part of the Belarus population to ionizing radiation. We analyzed the time trends of Down syndrome (DS) in Belarus to evaluate whether either brief exposure at high dose rates during the plume passage or continuous exposure at low doses and dose rates of the residents of contaminated areas had any detectable impact on DS prevalence at birth. DS data came from the Belarus National Registry of Congenital Malformations (1981-2001). We observed a significant peak of DS in January 1987 (26 cases observed and 9.84 expected; observed/expected ratio=2.64; 95% CI=1.72-3.76), but found no positive long-term time trends in contaminated or control areas. The time occurrence of the January peak, high dose rates during the plume passage and experimental data showing a radiosensitive phase of oogenesis around conception time in mammals suggest that the January peak may be linked to the Chernobyl plume.
Document type :
Journal articles
Complete list of metadatas

Cited literature [24 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00270550
Contributor : Pierre Verger <>
Submitted on : Saturday, April 5, 2008 - 5:37:57 PM
Last modification on : Thursday, February 7, 2019 - 3:48:37 PM
Long-term archiving on: : Friday, November 25, 2016 - 9:08:04 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Ivan Zatsepin, Pierre Verger, Elisabeth Robert-Gnansia, Bertrand Gagnière, Margot Tirmarche, et al.. Down syndrome time-clustering in January 1987 in Belarus: link with the Chernobyl accident?: Down syndrome after Chernobyl. Reproductive Toxicology, Elsevier, 2007, 24 (3-4), pp.289-95. ⟨10.1016/j.reprotox.2007.06.003⟩. ⟨inserm-00270550⟩

Share

Metrics

Record views

388