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Cancer mortality in cerebral palsy in California

Abstract : Exposure to lifestyle, occupational, and environmental risk factors for cancer are undoubtedly different in cerebral palsy (CP) than in the general population, and these differences and others may result in a specific pattern of cancer mortality in CP. Objective: To study the cancer mortality of CP in California. Study group: 40,482 CP cases (contributing 357,928 person-years) among 210,155 persons having received annual evaluations from the California Department of Developmental Services over the period 1988-2002 were followed. Methods: Mortality due to malignant and non-malignant neoplasms (ICD9 codes 140-239) in CP was compared with that in the Californian general population using age-standardized mortality ratios (SMRs). Results: An excess of overall cancer mortality (SMR 2.6, 95% CI 2.0-3.2) was found. Cancer mortality was elevated in CP for some sites, and others cancer deaths were underrepresented in CP. Deaths due to cancer of the esophagus (SMR = 5.40, 95% CI 3.09-8.77), colon (2.16, 1.35-3.27), liver (2.21, 1.06-4.06), breast (1.83, 1.24-2.62), and bladder (4.57, 2.09-8.68) were significantly overrepresented in CP, while deaths due to cancer of the trachea, bronchus and lung were underrepresented (0.22, 0.09-0.43). Conclusion: Cancer mortality in cerebral palsy has specific differences with the population at large, and these differences may illuminate important contributing behavioral, environmental, or health care factors.
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https://www.hal.inserm.fr/inserm-00270454
Contributor : Evelyne Mouillet <>
Submitted on : Friday, April 4, 2008 - 5:37:10 PM
Last modification on : Wednesday, November 29, 2017 - 2:54:18 PM
Long-term archiving on: : Friday, November 25, 2016 - 9:13:57 PM

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Steven Day, Jordan Brooks, David Strauss, Sharon Shumway, Robert Shavelle, et al.. Cancer mortality in cerebral palsy in California. International journal on disability and human development : IJDHD, 2008, 7 (4), pp.423-430. ⟨inserm-00270454⟩

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