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Why is HDL functionally deficient in type 2 diabetes?

Abstract : High-density lipoprotein (HDL) particles exert a spectrum of atheroprotective activities that can be deficient in type 2 diabetes. Key mechanisms leading to the formation of functionally deficient HDL involve 1) HDL enrichment in triglycerides and depletion in cholesteryl esters with conformational alterations of apolipoprotein A-I; 2) glycation of apolipoproteins and/or HDL-associated enzymes; and 3) oxidative modification of HDL lipids, apolipoproteins, and/or enzymes. Available data identify hypertriglyceridemia, with concomitant compositional modification of the HDL lipid core and conformational change of apolipoprotein A-I, as a driving force in functional alteration of HDL particles in type 2 diabetes. Therapeutic options for correcting HDL functional deficiency should target hypertriglyceridemia by normalizing circulating levels of triglyceride-rich lipoproteins.
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Contributor : Kontush Anatol <>
Submitted on : Friday, April 4, 2008 - 4:16:34 PM
Last modification on : Monday, December 14, 2020 - 9:43:54 AM
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  • HAL Id : inserm-00270419, version 1
  • PUBMED : 18366999



Kontush Anatol, John Chapman. Why is HDL functionally deficient in type 2 diabetes?. Current Diabetes Reports, Current Medicine Group, 2008, 8 (1), pp.51-9. ⟨inserm-00270419⟩



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