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Microtubule-associated protein 2 (MAP2) expression during synaptic plasticity in the guinea pig cochlea.

Abstract : The expression of different isoforms of microtubule-associated proteins 2 (MAP2), including the low molecular weight form MAP2c present mainly in developing neurons, was investigated in the primary auditory neurons after alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) perfusion in the guinea pig cochlea. MAP2 expression appeared to be tightly regulated in the repairing neurons. Neurite regrowth seems to involve the MAP2c isoform. In cochlear neurons, mechanisms involved in the period of development might be reactivated after excitotoxic injury in the mature cochlea.
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https://www.hal.inserm.fr/inserm-00267258
Contributor : Jérôme Ruel <>
Submitted on : Wednesday, March 26, 2008 - 7:37:27 PM
Last modification on : Thursday, March 5, 2020 - 6:38:45 PM

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  • HAL Id : inserm-00267258, version 1
  • PUBMED : 14644462

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Sabine Ladrech, Marc Lenoir, Jérôme Ruel, Jean-Luc Puel. Microtubule-associated protein 2 (MAP2) expression during synaptic plasticity in the guinea pig cochlea.. Hearing Research, Elsevier, 2003, 186 (1-2), pp.85-90. ⟨inserm-00267258⟩

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