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Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years.

Emanuelle Taioli 1 Laura Gaspari 1 Simone Benhamou 2 Paolo Boffetta 3 Jürgen Brockmoller 4 Dorota Butkiewicz 5 Ingolf Cascorbi 6 Margie Clapper 7 Vita Dolzan 8 Aage Haugen 9 Ari Hirvonen 10 Kirsti Husgafvel-Pursiainen 11 Ivan Kalina 12 Pierre Kremers 13 Loïc Le Marchand 14 Stephanie London 15 Agneta Rannug 16 Marjorie Romkes 17 Bernadette Schoket 18 Janeric Seidegard 19 Richard Strange 20 Isabelle Stücker 21 Jordi To-Figueras 22 Seymour Garte 23
1 IRCCS - Molecular and Genetic Epidemiology Unit
2 Unité de Recherches en Epidémiologie des Cancers
3 Unit of Environment Cancer Epidemiology
4 Institute of Clinical Pharmacology
5 Institute of Clinical Pharmacology
6 Ernst Moritz Arndt University
7 Fox Chase Cancer Centre
8 University of Ljubljana
9 National Institue of Occupational Health
10 Department of Industrial Hygiene and Toxicology
11 Unit of Excellence for Psychosocial Factors
12 Safarik University
13 Institut de Pathologie
14 UHM - University of Hawai‘i [Mānoa]
15 National Institute for Environmental Health Sciences Research Triangle Park
16 Karolinska Institutet [Stockholm]
17 Department of Computer Science - University of Pittsburgh
18 National Institute of Environmental Health
19 Lund University [Lund]
20 Keele University [Keele]
21 Recherches épidémiologiques et statistiques sur l'environnement et la santé.
22 Hospital Clinic Provincial
23 EOHSI - Environmental and Occupational Health Sciences Institute
Abstract : BACKGROUND: A genetic component of early-onset lung cancer has been suggested. The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens' metabolism and therefore in lung cancer risk. METHODS: The effect of metabolic gene polymorphisms on lung cancer at young ages was studied by pooling data from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database. All primary lung cancer cases of both sexes who were Caucasian and
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https://www.hal.inserm.fr/inserm-00266872
Contributor : U754 Secretariat <>
Submitted on : Tuesday, April 1, 2008 - 4:15:06 PM
Last modification on : Thursday, August 22, 2019 - 12:10:38 PM

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  • HAL Id : inserm-00266872, version 1
  • PUBMED : 12690010

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Emanuelle Taioli, Laura Gaspari, Simone Benhamou, Paolo Boffetta, Jürgen Brockmoller, et al.. Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years.. International Journal of Epidemiology, Oxford University Press (OUP), 2003, 32 (1), pp.60-3. ⟨inserm-00266872⟩

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