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Association of polymorphisms in the Tau and Saitohin genes with Parkinson's disease.

Abstract : BACKGROUND: The Saitohin gene has recently been identified in intron 9 of the Tau gene. Because an association between Parkinson's disease and Tau has been described, Saitohin represents a candidate gene for Parkinson's disease. OBJECTIVE: To test these two genes for their association with Parkinson's disease in a large community based case-control study. RESULTS: Cases (n = 208) were more often homozygotes for the Tau H1 haplotype than controls (n = 483; odds ratio (OR) = 1.71 (95% confidence interval, 1.20 to 2.43); p = 0.003), and the saitohin Q allele was in complete linkage disequilibrium with the H1 haplotype. This association was stronger among cases with Parkinson's disease onset below 65 years (< or =65 years: OR = 2.52 (1.49 to 4.25); p<0.001) than among those with older onset (>65 years: OR = 1.20 (0.73 to 1.98); p<0.47). CONCLUSIONS: The data suggest that there is a functional polymorphism at this locus involved in Parkinson's disease.
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Submitted on : Tuesday, March 25, 2008 - 3:41:39 PM
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Clotilde Levecque, Alexis Elbaz, Jacqueline Clavel, Jean-Sébastien Vidal, Philippe Amouyel, et al.. Association of polymorphisms in the Tau and Saitohin genes with Parkinson's disease.. Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group, 2004, 75 (3), pp.478-480. ⟨10.1136/jnnp.2003.015750⟩. ⟨inserm-00266828⟩



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