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CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease.

Alexis Elbaz 1 Clotilde Levecque 2 Jacqueline Clavel 3 Jean-Sébastien Vidal 4 Florence Richard 2 Philippe Amouyel 2 Annick Alpérovitch 1 Marie-Christine Chartier-Harlin 2 Christophe Tzourio 1
1 Recherches épidémiologiques en neurologie et psychopathologie
2 Epidémiologie des maladies chroniques: impact des intéractions gène environnement sur la santé des populations
3 Recherches épidémiologiques et statistiques sur l'environnement et la santé.
4 Service de neurologie [Saint-Antoine]
Abstract : We performed a case-control study of Parkinson's disease (PD) in a population characterized by a high prevalence of pesticide exposure and studied the joint effect of pesticide exposure and CYP2D6. Although they are based on a small group of subjects with the joint exposure, our findings are consistent with a gene-environment interaction disease model according to which (1) pesticides have a modest effect in subjects who are not CYP2D6 poor metabolizers, (2) pesticides' effect is increased in poor metabolizers (approximately twofold), and (3) poor metabolizers are not at increased PD risk in the absence of pesticide exposure.
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https://www.hal.inserm.fr/inserm-00266821
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Submitted on : Tuesday, March 25, 2008 - 3:34:10 PM
Last modification on : Tuesday, December 15, 2020 - 4:02:13 AM

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Alexis Elbaz, Clotilde Levecque, Jacqueline Clavel, Jean-Sébastien Vidal, Florence Richard, et al.. CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease.. Annals of Neurology, Wiley, 2004, 55 (3), pp.430-4. ⟨10.1002/ana.20051⟩. ⟨inserm-00266821⟩

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