Skip to Main content Skip to Navigation
Journal articles

CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease.

Abstract : We performed a case-control study of Parkinson's disease (PD) in a population characterized by a high prevalence of pesticide exposure and studied the joint effect of pesticide exposure and CYP2D6. Although they are based on a small group of subjects with the joint exposure, our findings are consistent with a gene-environment interaction disease model according to which (1) pesticides have a modest effect in subjects who are not CYP2D6 poor metabolizers, (2) pesticides' effect is increased in poor metabolizers (approximately twofold), and (3) poor metabolizers are not at increased PD risk in the absence of pesticide exposure.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00266821
Contributor : U754 Secretariat <>
Submitted on : Tuesday, March 25, 2008 - 3:34:10 PM
Last modification on : Wednesday, August 19, 2020 - 11:58:38 AM

Links full text

Identifiers

Citation

Alexis Elbaz, Clotilde Levecque, Jacqueline Clavel, Jean-Sébastien Vidal, Florence Richard, et al.. CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease.. Annals of Neurology, Wiley, 2004, 55 (3), pp.430-4. ⟨10.1002/ana.20051⟩. ⟨inserm-00266821⟩

Share

Metrics

Record views

217