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MHC Class II tetramers and the pursuit of antigen-specific T cells: define, deviate, delete.: MHC Class II tetramers

Abstract : Selective expansion and activation of a very small number of antigen-specific CD4(+) T cells is a remarkable and essential property of the adaptive immune response. Antigen-specific T cells were until recently identified only indirectly by functional assays, such as antigen-induced cytokine secretion and proliferation. The advent of MHC Class II tetramers has added a pivotal tool to our research armamentarium, allowing the definition of allo- and autoimmune responses in deeper detail. Rare antigen-specific CD4(+) cells can now be selectively identified, isolated and characterized. The same tetramer reagents also provide a new mean of stimulating T cells, more closely reproducing the MHC-peptide/TCR interaction. This property allows the use of tetramers to direct T cells toward the more desirable outcome, that is, activation (in malignancies and infectious diseases) or Th2/T regulatory cell deviation, anergy and deletion (in autoimmune diseases). These experimental approaches hold promise for diagnostic, prognostic and therapeutic applications.
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https://www.hal.inserm.fr/inserm-00266546
Contributor : Roberto Mallone <>
Submitted on : Wednesday, March 26, 2008 - 10:34:04 AM
Last modification on : Friday, March 27, 2020 - 2:33:32 AM
Long-term archiving on: : Thursday, May 20, 2010 - 10:25:49 PM

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Roberto Mallone, Gerald T Nepom. MHC Class II tetramers and the pursuit of antigen-specific T cells: define, deviate, delete.: MHC Class II tetramers. Clinical Immunology, Elsevier, 2004, 110 (3), pp.232-42. ⟨10.1016/j.clim.2003.11.004⟩. ⟨inserm-00266546⟩

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