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Anti-CD38 autoantibodies in type? diabetes.

Abstract : Human diabetes mellitus comprises two main clinical entities: type 1 and type 2 diabetes. While type 1 diabetes is autoimmune in origin, type 2 diabetes is due to a decreased sensitivity to insulin action (so-called insulin resistance) associated with impaired beta cell function. However, it is becoming increasingly clear that there is a certain overlap between these two diseases. While some degree of insulin resistance is present in type 1 diabetic patients, markers of beta cell autoimmunity (either primary or secondary) can frequently be detected in type 2 diabetic subjects. In this scenario, anti-CD38 autoantibodies (aAbs) have been described in both type 1 and type 2 diabetic patients. Contrary to the other known islet aAbs, anti-CD38 autoantibodies are more prevalent in long-standing than in new-onset type 1 diabetes, and more prevalent in type 2 than in type 1 diabetes. Moreover, anti-CD38 aAbs are endowed with unique stimulatory properties on Ca(2+) mobilization and insulin secretion. These observations suggest that autoimmunity may be both the cause and consequence of beta cell dysfunction, in either case imposing a further toll for the control of glucose homeostasis.
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Contributor : Roberto Mallone Connect in order to contact the contributor
Submitted on : Thursday, September 17, 2009 - 2:47:51 PM
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Roberto Mallone, Paolo Cavallo Perin. Anti-CD38 autoantibodies in type? diabetes.. Diabetes/Metabolism Research and Reviews, Wiley, 2006, 22 (4), pp.284-94. ⟨10.1002/dmrr.626⟩. ⟨inserm-00266518⟩



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