COX-2: an in vivo evidence of its participation in heat stress-induced myocardial preconditioning. - Archive ouverte HAL Access content directly
Journal Articles Cardiovascular Research Year : 2003

COX-2: an in vivo evidence of its participation in heat stress-induced myocardial preconditioning.

(1) , (1) , (1) , (1)
1

Abstract

OBJECTIVE: Heat stress (HS) is known to induce delayed protection against myocardial infarction. We have previously shown that inducible nitric oxide synthase (iNOS), was involved in mediating this form of preconditioning. Since iNOS and cyclooxygenase-2 (COX-2) are co-induced in various cell types, the goal of this study was to investigate whether COX-2 could also participate to the HS-induced cardioprotection. METHODS AND RESULTS: A total of 78 male Wistar rats, subjected to either heat stress (42 degrees C for 15 min) or sham anaesthesia were used for this study. Twenty-four hours later, they were treated or not with a selective COX-2 inhibitor, either celecoxib (3 mg kg(-1), i.p.) or NS-398 (5 mg kg(-1), i.p.), 30 min before being subjected to a 30-min occlusion of the left coronary artery followed by a 120-min reperfusion, in vivo. HS resulted in a marked increase in myocardial COX-2 protein expression at 24 h, associated with a significant protection against infarction (46.0+/-1.4% in sham vs. 26.8+/-3.8% in HS group) (P
Fichier principal
Vignette du fichier
COX-2.pdf (171.73 Ko) Télécharger le fichier
Loading...

Dates and versions

inserm-00266200 , version 1 (21-03-2008)

Identifiers

  • HAL Id : inserm-00266200 , version 1
  • PUBMED : 12798431

Cite

Claire Arnaud, Marie Joyeux-Faure, Diane Godin-Ribuot, Christophe Ribuot. COX-2: an in vivo evidence of its participation in heat stress-induced myocardial preconditioning.. Cardiovascular Research, 2003, 58 (3), pp.582-8. ⟨inserm-00266200⟩

Collections

INSERM UGA
79 View
778 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More